A5102850799- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Oral microbiology and periodontitis research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Salivary Gland Disorders and Functions
- Animal Virus Infections Studies
- Diagnosis and Treatment of Venous Diseases
- Cytomegalovirus and herpesvirus research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related gene regulation
- Clostridium difficile and Clostridium perfringens research
- Wound Healing and Treatments
- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Oral health in cancer treatment
- Periodontal Regeneration and Treatments
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Renal Transplantation Outcomes and Treatments
Johns Hopkins University
2022-2025
Third Xiangya Hospital
2021-2024
Central South University
2021-2024
National Health and Family Planning Commission
2023-2024
Background Previous studies have demonstrated enhanced efficacy of vaccine formulations that incorporate the chemokine macrophage inflammatory protein 3α (MIP-3α) to direct antigens immature dendritic cells. To address reduction in associated with a mutation severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutants, we examined ability receptor-binding domain vaccines incorporating MIP-3α sustain higher concentrations antibody when administered intramuscularly (IM) and more...
Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had Spike protein or domains thereof as immunogen. While is highly immunogenic, it also subject to genetic drift over time that has led a series variants concern continue evolve, requiring yearly updates vaccine formulations. In this study, we investigate potential N-terminal ectodomain ORF3a encoded by orf3a gene SCV2 be an evolution-resistant antigen. This domain conserved time, and, unlike...
Background Tuberculosis (TB) remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy cumbersome treatment required eradicate infection. Bacterial persistence during exposure bactericidal antibiotics is at least partially mediated bacterial stringent response enzyme, Rel Mtb . A therapeutic DNA vaccine targeting has been shown increase efficacy antitubercular drugs, fusing macrophage-inflammatory protein 3α (MIP-3α), which interacts with CCR6...
Background: The majority of antigen-based SARS-CoV-2 (SCV2) vaccines utilized in the clinic have had Spike protein or domains thereof as immunogen. While is highly immunogenic, it also subject to genetic drift over time, which has led a series variants concern that continue evolve, requiring yearly updates vaccine formulations. In this study, we investigate potential N-terminal ectodomain ORF3a encoded by orf3a gene SCV2 be an evolution-resistant antigen. This domain conserved and, unlike...
Tuberculosis (TB) remains among the leading infectious causes of death. Due to limited number antimicrobials in TB drug discovery pipeline, interest has developed host-directed approaches improve treatment outcomes. C-C motif chemokine-like receptor 2 (CCRL2) is a unique seven-transmembrane domain that upregulated by inflammatory signals and mediates leucocyte migration. However, little known about its role infection. Here, we show Mycobacterium tuberculosis (Mtb) infection increases CCRL2...
Introduction DNA vaccines containing a fusion of the gene encoding chemokine MIP-3α (CCL20), ligand for CCR6 on immature dendritic cells (DCs), to melanoma-associated antigen genes have enhanced anti-tumor immunity and efficacy compared those lacking gene. Previous work has shown that type-I interferon (IFNα or IFN) 5-Aza-2’-deoxycytidine (5Aza) significantly enhance therapeutic benefit as measured by reduced tumor burden improved mouse survival. Methods Here, we explored intratumoral immune...
Herein, a novel polymeric nanoparticle was designed to inhibit hepatoma carcinoma by simultaneously targeting the T cell immunoreceptor with Ig and ITIM domains (TIGIT)/poliovirus receptor (PVR) long noncoding RNAs antisense RNA in INK4 locus (LncRNA ANRIL). Firstly, siANRIL-loaded nanoparticles (NP-siANRIL) developed methoxy-poly (ethylene glycol)-polyamidoamine (mPEG-PAMAM) polyamidoamine-poly glycol)-disulphide bond-carboxyl (PAMAM-PEG-S2-COOH) using self-assembly method. Then DTBP-3...
Abstract Secondary hyperparathyroidism has a significant impact on the overall well‐being of body. Capsiates, known for their antioxidant and metabolic properties, have emerged as promising alternative treatment secondary hyperparathyroidism. This study aims to evaluate effects mechanisms capsiates in To achieve our research objectives, we conducted patients' serum examined changes markers using metabolomics. We induced rat through dietary intervention divided them into four groups. The...
Abstract Delayed graft function (DGF) is a frequently observed complication following kidney transplantation (KT). Our prior research revealed dynamic shifts in salivary microbiota post-KT with immediate (IGF), yet its behavior during DGF remains unexplored. Five recipients and 35 IGF were enrolled. Saliva samples collected the perioperative period, 16S rRNA gene sequencing was performed. The of IGFs changed significantly gradually stabilized recovery renal function. composition DGFs...
Abstract Mycobacterium tuberculosis ( Mtb) is one of the leading infectious causes death worldwide. There no available licensed therapeutic vaccine that shortens active (TB) disease drug treatment and prevents relapse, despite World Health Organization’s calls. Here, we show an intranasal DNA containing a fusion stringent response rel Mtb gene with encoding immature dendritic cell-targeting chemokine, MIP-3α/CCL20, duration curative TB in immunocompetent mice. Compared to first-line regimen...
Abstract Bibliometric analyses are often used as a means of visualising the knowledge base and associated trends patterns in target scientific field based on quantitative review corresponding literature. In this study, we explore current status research pertaining to biofilms wound healing elucidate space. Through process, gain insight into findings from papers indexed Web Science Core Collection. These references were then analysed plotted using Microsoft Excel 2019, VOSviewer, CiteSpace V....
Neural precursor cell expressed developmentally downregulated gene 4 (NEDD4) plays two opposite roles in carcinogenesis. It has been reported that NEDD4 inhibits hepatocellular carcinoma (HCC) progression; however, little is known about its potential function and molecular mechanism HCC the context of hepatitis B virus (HBV) infection. In this study, we analyzed expression 199 specimens with or without HBV infection observed was unrelated to exposure tumor tissue but high conferred better...
Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation persistent Mycobacterium ( Mtb ) remain in non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induction Rel -mediated stringent response. We developed novel therapeutic DNA vaccine containing fusion rel gene with encoding immature dendritic cell-targeting chemokine, MIP-3α/CCL20. To augment mucosal immune responses, intranasal delivery was also evaluated. found...
Renal transplantation is an effective treatment for the end stage renal disease (ESRD). However, how salivary microbiota changes during perioperative period of transplant recipients (RTRs) has not been elucidated. Five healthy controls and 11 RTRs who had good recovery were enrolled. Saliva samples collected before surgery at 1, 3, 7, 14 days after surgery. 16S rRNA gene sequencing was performed. There no significant difference in composition between ESRD patients controls. The showed higher...
Tuberculosis (TB) remains among the leading infectious causes of death. Due to limited number antimicrobials in TB drug discovery pipeline, interest has developed host-directed approaches improve treatment outcomes. C-C motif chemokine-like receptor 2 (CCRL2) is a unique seven-transmembrane domain that upregulated by inflammatory signals and mediates leucocyte migration. However, little known about its role setting infection. Here, we show
Abstract Lengthy tuberculosis (TB) treatment is required to address the ability of a subpopulation persistent Mycobacterium ( Mtb ) remain in non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induction Rel -mediated stringent response. We developed novel therapeutic DNA vaccine construct involving fusion rel gene with immature dendritic cell-targeting encoding chemokine MIP-3α/CCL20. To augment mucosal immune responses, intranasal delivery was also...
Immune checkpoint inhibitors (ICIs), including programmed cell death-1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) inhibitors, have potential therapeutic effects for hepatocellular carcinoma (HCC). However, ICIs enhance function may lead to graft rejection death of HCC patients after liver transplantation (LT), thus limiting its usage in LT recipients. In this review, the effect combination therapy (CTLA-4 PD-1) on acute was evaluated based patient's treatment outcome...