A5059546815- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Viral Infections and Vectors
- Viral Infectious Diseases and Gene Expression in Insects
- Retinal Diseases and Treatments
Harbin Veterinary Research Institute
2017-2024
Chinese Academy of Agricultural Sciences
2017-2024
Abstract African swine fever is a fatal infectious disease caused by virus (ASFV). The high mortality this significant challenge to the industry worldwide. ASFV virulence related its ability antagonize IFN response, yet mechanism of antagonism not understood. Recently, less virulent recombinant has emerged that EP402R gene deletion within parental HLJ/18 (ASFV-ΔEP402R) strain. encodes CD2v. Hence we hypothesized uses CD2v protein evade type I IFN–mediated innate immune response. We found...
// Liyuan Wang 1 , Xianling Tang Xiaolin Lv Encheng Sun 3 Donglai Wu Changlin 2 and Ping Liu Eye Hospital, The First Affiliated Hospital of Harbin Medical University, 150001, China Department Urology, State Key Laboratory Veterinary Biotechnology, Research Institute, Chinese Academy Agricultural Sciences, 150069, Correspondence to: Liu, email: pingliu53@126.com Keywords: CHST6 ; macular corneal dystrophy; endoplasmic reticulum stress; apoptosis; keratocytes Received: August 24, 2017...
African swine fever virus (ASFV) is a large double-stranded DNA with complex structural architecture and encodes more than 150 proteins, where many are unknown functions. E184L has been reported as one of the immunogenic ASFV proteins that may contribute to pathogenesis immune evasion. However, antigenic epitopes not yet characterized. In this study, recombinant protein was expressed in prokaryotic expression system four monoclonal antibodies (mAbs), designated 1A10, 2D2, 3H6, 4C10 were...
African swine fever virus (ASFV) is the causative agent of (ASF), a highly contagious disease that can kill up to 100% domestic pigs and wild boars. It has been shown inoculated with some ASF vaccine candidates display more severe clinical signs die earlier than do not immunized. We hypothesize antibody-dependent enhancement (ADE) ASFV infection may be caused by presence unidentified antibodies. In this study, we found ASFV-encoded structural protein A137R (pA137R) recognized anti-ASFV...
African swine fever virus (ASFV) poses serious threats to the global industry, food safety, and economy. Since August 2018, different types of ASFVs have successively emerged in China, making ASF diagnostics more challenging. The highly virulent genotype I recombinant has gradually become prevalent dominant strain is identified by sequencing several its genes, which time‐consuming expensive. Here, we developed a triplex real‐time quantitative PCR (qPCR) assay based on ASFV B646L, X64R,...