A5100429721- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Global trade and economics
- Hepatitis B Virus Studies
- Migration, Ethnicity, and Economy
- Retinal Diseases and Treatments
- PARP inhibition in cancer therapy
- Hydrogen's biological and therapeutic effects
- Analytical Chemistry and Sensors
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Toxoplasma gondii Research Studies
- Genetic factors in colorectal cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Adsorption and biosorption for pollutant removal
- Cancer Immunotherapy and Biomarkers
- Molecular Communication and Nanonetworks
- Asymmetric Hydrogenation and Catalysis
- Retinal and Optic Conditions
- Ultrasound and Hyperthermia Applications
- Inflammasome and immune disorders
- Microbial Inactivation Methods
- Radioactive element chemistry and processing
- Drug-Induced Ocular Toxicity
- Heavy Metal Exposure and Toxicity
Heilongjiang University of Chinese Medicine
2021-2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2021-2025
Tea Research Institute
2021-2024
Chinese Academy of Agricultural Sciences
2021-2024
Fujian Normal University
2024
Bengbu Medical College
2023-2024
Harbin Medical University
2015-2023
Shandong University
2022-2023
Anhui Normal University
2023
First Affiliated Hospital of Harbin Medical University
2015-2023
The amino acid antiporter system Xc- is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While activity often positively correlates with expression level its light chain encoded by SLC7A11, inhibition small molecules (e.g., erastin) causes a decrease in intracellular GSH level, leading ferroptotic cell death. How regulated during ferroptosis remains largely unknown....
Injectable, biocompatible and rechargeable fiber batteries are created for all-region power supply <italic>in vivo</italic>. Fiber produce a density of 78.9 mW cm<sup>−3</sup> demonstrated to satisfy various biomedical applications in the body.
Children and adolescents' myopia is a major public problem. Although the clinical effect of various interventions has been extensively studied, there lack national-level integral assessments to simultaneously quantify economics effectiveness comprehensive prevention control programs. We aimed compare cost-effectiveness between traditional strategy, digital strategy school-based screening program in China.A Markov model was used cost-utility among screening, 6 18-year-old rural urban...
Optic atrophy (OA) is primarily caused by damage to the retinal pathway system, including widespread degeneration of ganglion cells and axons, leading visual impairment blindness. Despite its clinical significance diverse etiological factors, there currently a lack comprehensive bibliometric analyses exploring research trends hotspots within this field. This study retrieved relevant literature on OA published between 2003 2023 from Web Science Core Collection database. We conducted analysis...
Kazakhstan is the first place to advocate “the Belt and Road” initiative. The original intention of proposing this initiative draw on ancient Silk Road, take connectivity as main line, strengthen policy communication, facility connectivity, trade facilitation, financial integration, people-to-people with other countries, inject new momentum into world economic growth, open up space for global development, create platforms international cooperation. Since establishment diplomatic relations...
Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase (CHST6) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS precipitate keratocytes stroma. We investigated roles for inflammatory responses MCD pathogenesis by examining lysosomal-autophagy pathway activation of pyroptosis keratocytes. Normal lesioned were obtained from patients undergoing transplantation. The subjected sequencing, RT-PCR, western blotting, transmission...
Thiel-Behnke corneal dystrophy (TBCD) is an epithelial-stromal TGFBI caused by mutations in the (transforming growth factor beta induced) gene, though underlying mechanisms and pathogenesis of TBCD are still obscure. The study identifies a novel mutation gene (p.Gly623_His626del) pedigree. Characteristics typical vacuole formation, irregular epithelial thickening thinning, deposition eosinophilic substances beneath epithelium, involvement anterior stroma were observed this pedigree via...
Tea (Camellia sinensis) is widely cultivated throughout the world for its unique flavor and health benefits. Galloylated catechins in tea plants serve as important secondary metabolites that play a pivotal role taste determination pharmacological effects. However, genetic basis of galloylated traits remains elusive. We identified stable major-effect quantitative trait locus (QTL) associated with index (GCI), designated qGCI6.2. Within QTL's confidence interval, two shikimate dehydrogenases...
Fluoride ions are highly relevant in environmental and biological sciences, there is a very limited number of established fluoride chemical sensors. Previous fluoride-selective optodes were demonstrated with metal-porphyrin as the ionophore required chromoionophore for optical signal transduction. We demonstrate here novel sensing nano-optodes containing an aluminum-phthalocyanine complex (AlClPc) single active component, simplifying conventional ion-selective approach. The interrogated...
// Liyuan Wang 1 , Xianling Tang Xiaolin Lv Encheng Sun 3 Donglai Wu Changlin 2 and Ping Liu Eye Hospital, The First Affiliated Hospital of Harbin Medical University, 150001, China Department Urology, State Key Laboratory Veterinary Biotechnology, Research Institute, Chinese Academy Agricultural Sciences, 150069, Correspondence to: Liu, email: pingliu53@126.com Keywords: CHST6 ; macular corneal dystrophy; endoplasmic reticulum stress; apoptosis; keratocytes Received: August 24, 2017...
The calcium-activated chloride channel (CLCA4) in colon adenocarcinoma (COAD) and immunological infiltration have not been extensively studied. This work thoroughly employed several datasets to assess the expression, prognosis, association between immune clinicopathological characteristics of CLCA4 cancer, as well look into potential signalling pathways. human protein atlas (HPA), TIMER, UALCAN, TISIDB, GSCA, SangerBox, GeneMANIA, LinkedOmics were among that used. findings demonstrated that,...
Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV), existing as a stable minichromosome in the hepatocyte, is responsible for persistent HBV infection. Maintenance and sustained replication cccDNA require its interaction with both viral host proteins. However, cccDNA-interacting factors that limit remain elusive.Minicircle (MC-HBV), recombinant cccDNA, was constructed based on chimeric intron minicircle technology. By mass spectrometry pull-down biotinylated MC-HBV,...
Hepatitis B virus (HBV) infection remains a major challenge to global health due unsatisfactory treatment efficacy, side effects of current therapies, and immune tolerance. Toll-like receptors 7/8 (TLR7/8) agonists have shown great potential in chronic hepatitis (CHB) cure, but systemic administration often induces severe rapid dispersion into the microvasculature. Herein, we encapsulate an imidazoquinoline-based TLR7/8 agonist (IMDQ) zeolitic imidazolate framework 8 nanoparticles...
Abstract Grass‐planting measure is a crucial vegetation approach to mitigate understory soil erosion and improve ecological environment in the red region of southern China. This study aimed quantify effects grass ( Paspalum wettsteinii Hackel.)‐planting measures on runoff sediment reduction slopes Masson pine plantations under rainstorm conditions. We conducted rainfall simulation experiment at intensity 2.0 mm/min, comparing single strip (MT1, spacing: 145 cm), double strips (MT2, 70 triple...
Objectives: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence. However, it is still less known how the host immune system responds cccDNA suppresses HBV replication. Therefore, essential explore proteins that interact with efficiently suppress Design: The interaction of ABCF1 was assessed by ChIP pull-down assay. replication in different cell models, including surrogate-transfected HBV-infected hepatocytes models. Phase separation...
Abstract A novel method was developed to prepare the branch of paclitaxel using 2, 4‐dichlorophenylaldehyde as starting material. The synthesized through condensation, cycloaddition and catalyzing hydrogenation dichlorophenyl intermediate. Tripolycyanamide formaldehyde resin‐Pd complex catalyst has been studied. influence temperature N/Pd atomic ratio on effect catalytic investigated optimum conditions were found. Because mild cyclization reaction condition, convenient asymmetric resolution...
Deyeuxia angustifolia is the dominant species in natural grassland of Sanjiang plain Heilongjiang province China.In this study, two sequencing libraries prepared from control (T1) and samples treaded by elevated CO2 (T2) were sequenced to investigate changes D. transcriptome responsed high concentration.In total, 80,215 unigenes found 49,094 (61.20%) annotated with gene descriptions, conserved domains, ontology terms metabolic pathways a cut-off E-value 10 -5 .These included 61 GO terms, 193...