A5060250527- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Adrenal and Paraganglionic Tumors
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Single-cell and spatial transcriptomics
- Plant-derived Lignans Synthesis and Bioactivity
- Neurogenesis and neuroplasticity mechanisms
- Telomeres, Telomerase, and Senescence
- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
- Cerebrospinal fluid and hydrocephalus
Zhejiang University
2025
Wenzhou Medical University
2013-2024
First Affiliated Hospital of Wenzhou Medical University
2013-2024
ABSTRACT Microglial phagocytosis of haematomas is crucial for neural functional recovery following intracerebral haemorrhage (ICH), a process regulated by various factors from within and outside the central nervous system (CNS). Extracellular vesicles (EVs), significant mediators intercellular communication, have been demonstrated to play pivotal role in pathogenesis progression CNS diseases. However, regulatory endogenous EVs on phagocytic capacity microglia post‐ICH remains elusive....
Abstract Ciclopirox (CPX) is an antifungal drug that has recently been reported to act as a potential anticancer drug. However, the effects and underlying molecular mechanisms of CPX on glioblastoma multiforme (GBM) remain unknown. Bortezomib (BTZ) first proteasome inhibitor-based approved treat multiple myeloma mantle cell lymphoma, BTZ exhibits toxic diverse tumor cells. Herein, we show displays strong anti-tumorigenic activity GBM. Mechanistically, inhibits GBM cellular migration invasion...
Malignant glioma is the most devastating and aggressive tumour in brain characterised by high morbidity, mortality extremely poor prognosis. The main purpose of present study was to investigate effects schisandrin B (Sch B) on cells both vitro vivo explore possible anticancer mechanism underlying Sch B-induced apoptosis cell cycle arrest.The anti-proliferative ability were assessed MTT clony formation assays. Flow cytometric analysis used detect changes. Apoptosis determined Hoechst 33342...
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults, which chemokines are often upregulated may play pivotal roles their development progression. Chemokines a large subfamily of cytokines with leukocyte chemotactic activities involved various However, gene expression patterns on global scale were not known GBM.Differentially expressed chemokine genes glioma normal samples screened by using The Cancer Genome Atlas (TCGA) database. Cox regression identified...
To date, the management of dopamine agonist (DA)-resistant prolactinomas remains a major clinical problem. Previously, we determined that miRNA-93 expression increases in DA-resistant prolactinomas; however, role DA resistance largely unexplored. Hence, this study aimed to investigate susceptibility tumor cells cabergoline (CAB) and autophagy changes MMQ GH3 after overexpression or inhibition. We used bioinformatics identify potential target miRNA-93. Subsequently, analyzed correlation...
Insights into the roles of microRNAs (miRNAs/miRs) in development and disease, particularly cancer, have made miRNAs attractive tools targets for novel therapeutic approaches treatment glioma. miR‑34a, as a well‑known tumor suppressor miRNA, is closely related with cellular senescence. Mesenchymal stem cells (MSCs) are major component microenvironment possess ability to deliver exogenous miRs glioma exert anti‑tumor effects. The present study investigated whether modified MSCs miR‑34a an...
Glioblastoma (GBM) is one of the most malignant types tumors in central nervous system, and 5-year survival remains low. Several studies have shown that preoperative peripheral blood tests conventional Magnetic Resonance Imaging (MRI) examinations affect prognosis GBM patients. Therefore, it necessary to construct a risk score based on test MRI develop multielement prognostic nomogram for GBM.This study retrospectively analyzed 131 Determination association between variables was performed by...
Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals society. Mesenchymal stem cell (MSC) therapy a promising approach for ischemic brain injury. However, MSC treatment potential progressively reduced with age, limiting their therapeutic efficacy repair post‑stroke. C1q tumor necrosis factor‑related protein 9 (CTRP9) novel cytoprotective cytokine antioxidant effects, which highly expressed in tissue. The present study...
Paclitaxel is an herbal active ingredient used in clinical practice that shows anti-tumor effects. However, its biological activity, mechanism, and cancer cell-killing effects remain unknown. Information on the chemical gene interactions of paclitaxel was obtained from Comparative Toxicogenomics Database, SwishTargetPrediction, Binding DB, TargetNet databases. Gene expression data were GSE4290 dataset. Differential analysis, Kyoto Encyclopedia Genes Genomes, Ontology analyses performed. set...
Glioblastoma (GB) is recognized as one of the most aggressive brain tumors, with a median survival 14.6 months. However, there are still some patients whose time was greater than 3 years, and biological reasons behind this clinical phenomenon arouse our research interests. By conducting proteomic analysis on tumor tissues obtained from GB who survived over years compared to those less 1 year, we identified significant upregulation SelK in shorter times. Therefore, hypothesized that may be an...
Cabergoline (CAB) is the first choice for treatment of prolactinoma and most common subtype pituitary adenoma. However, drug resistance lack effectiveness in other tumor types remain clinical challenges to this treatment. Brusatol (BT) known inhibit cell growth promote apoptosis a variety cancer cells. In our present studies, we investigate effects BT on proliferation vitro vivo. resulted an increase Annexin V-expressing cells promoted expression apoptosis-related proteins rat human...
BACKGROUND Dopamine agonists (DAs) are the first-line treatment for prolactinomas. DAs primarily target dopamine D2 receptor (D2R). Tumor stem-like cells (TSLCs) associated with tolerance to radiotherapy and chemotherapy. TSLCs have also been identified in pituitary adenomas. We aimed characterize expression pattern of stem cell markers D2R human rat MATERIAL AND METHODS Human prolactinoma specimens (n=14) were obtained from patients surgical resection. The xenograft model prolactinomas was...
Background Glioblastoma multiforme (GBM) is a common malignant brain tumor with high mortality. It urgently necessary to develop new treatment because traditional approaches have plateaued. Purpose Here, we identified an immune-related gene (IRG)-based prognostic signature comprehensively define the prognosis of GBM. Methods samples were selected from Chinese Glioma Genome Atlas (CGGA). We retrieved IRGs ImmPort data resource. Univariate Cox regression and LASSO analyses used our predictive...
Cancer stem cells (CSCs), which have been isolated from various malignancies, were closely correlated with the occurrence, progression, metastasis and recurrence of malignant cancer. Little is known about tumor stem-like (TSLCs) benign tumors. Here we want to explore global expression profile RNA MMQ rat prolactinoma cells. In this study, total was extracted profiles determined by Agilent Rat 8 × 60 K Microarray. Then used qRT-PCR test result Microarray, found VEGFA had a distinct pattern in...
Aim: This study aimed to identify the independent risk factors of recurrence in patients undergoing primary resection meningioma and construct a scoring system for prediction postoperative recurrence. Materials Methods: The clinical data 591 who underwent surgical at First Affiliated Hospital Wenzhou Medical University between November 2010 December 2016 were retrospectively reviewed. clinical, radiological, pathological characteristics evaluated, identified via receiver operating...
Neuroinflammatory processes have been identified as playing a crucial role in the pathophysiology of various neurodegenerative diseases, including idiopathic normal-pressure hydrocephalus (iNPH). iNPH, defined common disease cognitive impairment older adults, poses major challenges for therapeutic interventions owing to stringent methodological requirements relevant studies, clinical heterogeneity, unclear etiology, and uncertain diagnostic criteria. This study aims assess relationship...
Objectives To explore the in vitro culture condition of tumor stem-like cells isolated from rat prolactinoma MMQ cell lines and to observe their characteristics proliferation, differentiation, formation planted tumor. Methods MMQ were cultured with serum-free medium suspension containing epidermal growth factor (EGF) basic fibroblast (bFGF), stem spheres (briefly spheres) obtained. Clone was conducted its proliferative capacity observed. Then flow cytometry used detect CD133-positive...