A5056948476- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Particle Dynamics in Fluid Flows
- Advanced Breast Cancer Therapies
- Cyclone Separators and Fluid Dynamics
- Aquaculture disease management and microbiota
- Plant Molecular Biology Research
- Fungal and yeast genetics research
- Cancer Cells and Metastasis
- Combustion and Detonation Processes
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Vibrio bacteria research studies
- Viral Infections and Outbreaks Research
- Iron Metabolism and Disorders
- SARS-CoV-2 and COVID-19 Research
- Sharing Economy and Platforms
- Lung Cancer Research Studies
- Technology Use by Older Adults
- Intensive Care Unit Cognitive Disorders
- Polysaccharides and Plant Cell Walls
- Mosquito-borne diseases and control
- Physiological and biochemical adaptations
- Cancer Immunotherapy and Biomarkers
- Aerosol Filtration and Electrostatic Precipitation
Liaoning Cancer Hospital & Institute
2019-2025
China Medical University
2019-2025
Shanghai Medical College of Fudan University
2025
Dalian Medical University
2024
Second Affiliated Hospital of Inner Mongolia Medical University
2024
First Affiliated Hospital of Hebei Medical University
2023
Shanghai Jiao Tong University
2023
Dalian University of Technology
2023
Beijing University of Technology
2022
Heilongjiang Vocational Institute of Ecological Engineering
2022
Glioma is a malignant tumor that affects all kinds of people over the world. It demonstrates remarkable infiltrative and invasive features. The high expression interleukin-13 receptor subunit alpha-2 (IL-13Rα2) reportedly plays pivotal role in some cancers. However, whether IL-13Rα2 contributes to glioma remains unknown. This study significantly up-regulated human tissue samples. also associated with late stages disease progression diminished survival patients. Gain- loss-of-function studies...
Photoperiod and temperature are two pivotal regulatory factors of plant flowering. The floral transition plants depends on accurate measurement changes in photoperiod temperature. flowering time rice (Oryza sativa) as a facultative short-day (SD) is delayed under long-day (LD) and/or low conditions. To elucidate the functions rice, we systematically analyzed expression regulation several key genes (Hd3a, RFT1, Ehd1, Ghd7, RID1/Ehd2/OsId1, Se5) involved photoperiodic pathway different...
Crimean-Congo hemorrhagic fever virus (CCHFV) is a medically important tick-borne virus, causing severe diseases in humans. There no approved vaccines and therapeutics for CCHFV infection. The study of authentic requires biosafety level 3 facilities, hindering the research development antivirals. Here we report generation recombinant vesicular stomatitis (VSV) bearing both glycoprotein precursor (GPC) EGFP reporter (rVSV-CCHFV-GFP). We also find that acquisition an unexpected single R516K...
ABSTRACT The SARS-CoV-2 pandemic and the emergence of novel variants underscore need to understand host-virus interactions identify host factors that restrict viral infection. Here, we perform a genome-wide CRISPR knockout screen restriction for SARS-CoV-2, revealing DAZAP2 as potent antiviral gene. DAZAP2, previously implicated in restriction, is found inhibit entry by blocking virion fusion with both endolysosomal plasma membranes. Additionally, suppresses genomic RNA replication without...
Coronaviruses, including SARS-CoV-2, rely on host factors for their replication and pathogenesis, while hosts deploy defense mechanisms to counteract viral infections. Although numerous proviral have been identified, the landscape of restriction underlying remain less explored. Here, we conducted genome-wide CRISPR knockout screens using three distinct coronaviruses-SARS-CoV-2, HCoV-OC43 (a common cold human virus from genus Betacoronavirus) porcine epidemic diarrhea (Alphacoronavirus)...
ABSTRACT Trastuzumab and pertuzumab combined with chemotherapy represent the standard therapy for first‐line treatment of HER2‐positive metastatic breast cancer (BC). Due to challenges related availability cost in China, it is necessary explore treatments involving tyrosine kinase inhibitors (TKIs). In this multicenter, single‐arm, open‐label phase II trial, patients BC were enrolled from seven hospitals China. Patients received oral pyrotinib 400 mg once daily intravenous nab‐paclitaxel 125...
So far, it has been still unknown how liamocins are biosynthesized, regulated, transported and secreted. In this study, a highly reducing polyketide synthase (HR-PKS), mannitol-1-phosphate dehydrogenase (MPDH), mannitol (MtDH), an arabitol (ArDH) esterase (Est1) were found to be closely related core biosynthesis of extracellular in Aureobasidium melanogenum 6-1-2. The HR-PKS was responsible for 3,5-dihydroxydecanoic acid. MPDH MtDH implicated the ArDH involved biosynthesis. Est1 catalyzed...
Land type survey is an important task of land resources and the basis scientific management resources. With increasingly prominent problems population, resources, environment, there urgent need for a fast accurate classification method large-scale use cover based on remote sensing data. Traditional machine learning methods pixel achieved sufficient results are widely used, such as maximum likelihood random forests method. However, with development novel technology deep learning, in practical...
Objective This study aims to identify effective gene networks and biomarkers predict response prognosis for HER2-negative breast cancer patients who received sequential taxane-anthracycline neoadjuvant chemotherapy. Materials Methods Transcriptome data of training dataset including 310 treatment an independent validation set with 198 samples were analyzed by weighted co-expression network analysis (WGCNA) approach in R language. Gene ontology (GO) terms Kyoto Encyclopedia Genes Genomes...
The solute carrier 4 (SLC4) family is a class of cell membranes transporters involved in base transport that plays crucial roles diverse physiological processes. In our study, 15 slc4 genes were identified and annotated spotted sea bass, including five members Cl−/HCO3− exchangers, eight coding Na+-dependent HCO3− transporters, two copies Na+-coupled borate transporters. gene sequence structure, chromosomal syntenic arrangement, phylogenetic evolution profiles analyzed. Results showed the...
This study aimed to analyse the correlation between expression of cell proliferation-associated antigen (Ki-67), cycle protein-dependent kinase 4 (CDK4), epidermal growth factor receptor (EGFR), tumour-infiltrating lymphocytes (TILs) and circulating tumour DNA (ctDNA) with outcome prognosis patients breast cancer (BC) undergoing neoadjuvant chemotherapy (NACT).
BACKGROUND Dopamine agonists (DAs) are the first-line treatment for prolactinomas. DAs primarily target dopamine D2 receptor (D2R). Tumor stem-like cells (TSLCs) associated with tolerance to radiotherapy and chemotherapy. TSLCs have also been identified in pituitary adenomas. We aimed characterize expression pattern of stem cell markers D2R human rat MATERIAL AND METHODS Human prolactinoma specimens (n=14) were obtained from patients surgical resection. The xenograft model prolactinomas was...
The elasto-magnetic method is a promising pathway for cable force monitoring in cable-stayed bridges. Under the action of an externally applied pulsed magnetic field, both variation main flux recorded by induction coil and localized surface field measured packaged sensor are typical signals observing effect tensioned cables. However, performances parameters extracted from two types never strictly compared experiment. Meanwhile, comprehensive indicators evaluating ability on characterization...
In this pager, the geographic information systems(GIS) was brought into area of urban video surveillance. order to integrate stream a data collection image frames with their spatial attributes, system composed camera-oriented coordination, coordinate transformation, abstraction generation, semantic generation and graphics vectorization. On basis that, can get dealt by GIS, 3D maps be built for dynamic target searching association analysis.
Molten salts are now widely used as heat transfer fluids in solar thermal plants and molten salt nuclear reactors. In order to explore its enhancement method, new coaxial cross twisted tapes (CCTTs) applied plain tube with FLiBe working fluid, the characteristics of pressure drop numerically investigated by CFD software STAR-CCM+. Simulations performed a laminar flow regime where Reynolds number ranges from 100 1100, velocity, temperature profiles, enhanced performance evaluation criteria...
The prognosis for female patients with locally advanced breast cancer (LABC) has improved the emergence of novel drugs, especially those who have HER2 overexpression or ERBB-2 amplification. Trastuzumab-based regimen been paradigm in guidelines as first-line therapy, whereas many got progressive disease after several cycles treatment rapidly progress because primary resistance. Point mutations ERBB2 gene occur both HER2-amplication and non-amplification patients, a 2% ratio cohort 1.48%...