A5034055544- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Animal Disease Management and Epidemiology
- X-ray Diffraction in Crystallography
- RNA and protein synthesis mechanisms
- Crystallization and Solubility Studies
- Polyomavirus and related diseases
- Cancer Research and Treatments
- Enzyme Production and Characterization
- Cell death mechanisms and regulation
- Cytomegalovirus and herpesvirus research
- Advanced biosensing and bioanalysis techniques
- Plant Virus Research Studies
- CRISPR and Genetic Engineering
- Biosensors and Analytical Detection
- DNA Repair Mechanisms
- RNA regulation and disease
- Animal Virus Infections Studies
- Endoplasmic Reticulum Stress and Disease
- Viral Infectious Diseases and Gene Expression in Insects
California Institute of Technology
2019
Chinese Academy of Sciences
2013-2015
Institut Pasteur of Shanghai
2014
The development of vaccines against infectious diseases represents one the most important contributions to medical science. However, vaccine-preventable still cause millions deaths each year due thermal instability and poor efficacy vaccines. Using human enterovirus type 71 vaccine strain as a model, we suggest combined, rational design approach improve thermostability immunogenicity live by self-biomineralization. biomimetic nucleating peptides are rationally integrated onto capsid reverse...
Human enterovirus 71 (EV71) is the major causative agent of severe hand-foot-and-mouth diseases (HFMD) in young children, and structural characterization EV71 during its life cycle can aid development therapeutics against HFMD. Here, we present atomic structures full virion an uncoating intermediate a clinical C4 strain to illustrate changes that lead formation prepared for RNA release. Although VP1 N-terminal regions observed penetrate through junction channel at quasi-3-fold axis...
ABSTRACT Human enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the two major causative agents for hand-foot-and-mouth disease (HFMD). Previously, we demonstrated that a virus-like particle (VLP) EV71 produced from Saccharomyces cerevisiae is potential vaccine candidate against infection, an EV71/CVA16 chimeric VLP can elicit protective immune responses both virus infections. Here, presented crystal structures of VLPs, showing linear conformational neutralization epitopes identified...
Besides TopBP1, ETAA1 has been identified more recently as an activator of the ATR-ATRIP complex in human cells. We have examined role Xenopus egg-extract system, which instrumental study ATR-ATRIP. Depletion from egg extracts did not noticeably reduce activation response to replication stress, monitored by ATR-dependent phosphorylation Chk1 and RPA. Moreover, lack appear affect DNA during unperturbed S-phase. Significantly, we find that TopBP1 is considerably abundant than extracts....