A5006549177- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Alzheimer's disease research and treatments
- Viral gastroenteritis research and epidemiology
- Metabolism and Genetic Disorders
- Corneal surgery and disorders
- Bacteriophages and microbial interactions
- Genetics and Neurodevelopmental Disorders
- interferon and immune responses
- Cerebrovascular and Carotid Artery Diseases
- 3D Printing in Biomedical Research
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
- Pharmacological Effects and Toxicity Studies
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
- Metabolism, Diabetes, and Cancer
- Intracerebral and Subarachnoid Hemorrhage Research
- Glycosylation and Glycoproteins Research
Chongqing Medical University
2017-2025
Second Affiliated Hospital of Chongqing Medical University
2017-2025
Dalian Medical University
2017-2025
Wuhan University
2024
Shanghai University of Traditional Chinese Medicine
2014-2023
Guangxi University
2023
Central Hospital of Putuo District
2023
Guangxi Normal University
2021
Sir Run Run Shaw Hospital
2012-2015
Zhejiang University
2009-2015
A newly identified severe acute respiratory syndrome coronavirus (SARS-CoV), is the etiological agent responsible for outbreak of SARS. The SARS-CoV main protease, which a 33.8-kDa protease (also called 3C-like protease), plays pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing two replicase polyproteins, pp1a (486 kDa) pp1ab (790 kDa). Here, we report crystal structures at different pH values complex with specific inhibitor....
The development of vaccines against infectious diseases represents one the most important contributions to medical science. However, vaccine-preventable still cause millions deaths each year due thermal instability and poor efficacy vaccines. Using human enterovirus type 71 vaccine strain as a model, we suggest combined, rational design approach improve thermostability immunogenicity live by self-biomineralization. biomimetic nucleating peptides are rationally integrated onto capsid reverse...
Gastric and colorectal cancers are among the most common worldwide cause serious cancer mortality. Both epigenetic genetic disruptions of tumour suppressor genes (TSGs) frequently involved in their pathogenesis. Here, we studied alterations a novel TSG-PCDH17 its functions pathogenesis these tumours. We found that PCDH17 was silenced methylated almost all gastric cell lines as well ∼95% primary tumours, but not normal colonic mucosa. Moreover, deletion detected only 18% 12% tissues,...
Neutrophils and neutrophil extracellular traps (NETs) have been identified as crucial contributors in several neuroinflammatory models, such stroke traumatic brain injury, but their role sepsis-associated encephalopathy (SAE) has not thoroughly investigated. In this study, we established an SAE model using cecal ligation puncture (CLP) surgery to examine infiltration NETs formation. A protein arginine deiminase 4 (PAD4) inhibitor, GSK484, was employed suppress release. To assess changes...
We're not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare (squares), biomineralized (red circles) can be stored at ambient temperature without refrigeration for up a week and retain biological activity both in vitro (see graph), as well mouse model. Detailed facts of importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but copy-edited or typeset....
Background Recent studies have shown that embryonic stem (ES) cells globally express most genes in the genome at mRNA level; however, it is unclear whether this global expression propagated to protein level. Cell surface proteins could perform critical functions ES cells, so determining cell would significant implications for biology. Methods and Principal Findings The of mouse were purified by biotin labeling subjected proteomics analysis. About 1000 transmembrane or secreted identified....
Zinc-α2-glycoprotein (ZAG) is a 42-kDa protein reported as an anti-inflammatory adipocytokine. Evidences from clinical and experimental studies revealed that brain inflammation plays important roles in epileptogenesis seizure. Interestingly, closely relationship between ZAG many inflammatory mediators has been proven. Our previous study identified neurons found decreased epilepsy interacts with TGFβ ERK. This aimed to investigate the role of seizure explore its effect on seizure-related...
Objective: To identify risk factors for early neurological deterioration (END) in acute lacunar stroke patients and its influence on functional outcome. Methods: Consecutive defined by magnetic resonance imaging (MRI) between January 2018 June 2020 were included the study. END was as any persisting increase National Institutes of Health Stroke Scale (NIHSS) score ⩾ 2 points post admission, favorable outcome a modified Rankin (mRS) 0–2 at discharge. Univariable multivariable logistic...
Kein Kühlschrank nötig: Durch In-situ-Biomineralisation erhalten Vakzin-Partikel eine Schale, die ihre Thermostabilität erhöht. Im Unterschied zum blanken Vakzin (schwarze Quadrate) kann das biomineralisierte (rote Kreise) ohne Kühlung bis zu einer Woche gelagert werden. Dabei behält es seine biologische Aktivität sowohl in vitro als auch einem Mausmodell.
Background . Previous studies investigated the risk of suicide in patients with Parkinson’s disease (PD) but reported discrepant results. Deep brain stimulation (DBS) is an effective therapy for PD, while its effect on has seldom been researched. This meta-analysis aimed to estimate and/or suicidal ideation PD and who underwent DBS. Methods Relevant articles published PubMed or EMBASE CNKI database from 1990 December 2019 were sourced, combined standardized mortality rate (SMR) odds ratio...