A5083518076- Neuroinflammation and Neurodegeneration Mechanisms
- Hydrogen's biological and therapeutic effects
- Restless Legs Syndrome Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Calcium signaling and nucleotide metabolism
- Sleep and related disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- S100 Proteins and Annexins
- Spinal Cord Injury Research
- Diet, Metabolism, and Disease
- Ion Channels and Receptors
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Metabolism, Diabetes, and Cancer
- Sleep and Wakefulness Research
Dalian Medical University
2022-2025
Chongqing Medical University
2022-2025
Second Affiliated Hospital of Chongqing Medical University
2022-2025
University of Chinese Academy of Sciences
2025
First Affiliated Hospital of Jinan University
2023
Neutrophils and neutrophil extracellular traps (NETs) have been identified as crucial contributors in several neuroinflammatory models, such stroke traumatic brain injury, but their role sepsis-associated encephalopathy (SAE) has not thoroughly investigated. In this study, we established an SAE model using cecal ligation puncture (CLP) surgery to examine infiltration NETs formation. A protein arginine deiminase 4 (PAD4) inhibitor, GSK484, was employed suppress release. To assess changes...
Diabetic cardiomyopathy (DCM), a cardiac complication of diabetes, is the main cause high prevalence heart failure and associated mortality in diabetic patients. Oxidative stress lipid metabolism disorder-induced myocardial cell damage are part pathogenesis DCM. In this study, we investigated effects alpha-mangostin (A-MG), natural antioxidant extracted from mangosteen peel, on vitro vivo DCM models. H9C2 rat cardiomyocytes were treated with glucose (HG) palmitic acid (PA) for 24 h to...
Background: High-altitude cerebral edema (HACE), arising from exposure to acute hypobaric hypoxia (HH), is a severe and potentially life-threatening evolution of mountain sickness (AMS) in high altitude areas. CD13 reported facilitate angiogenesis by degrading extracellular matrix, including tight junctions (TJs). As an effective inhibitor, bestatin has demonstrated benefits anti-angiogenic therapies for various tumors. However, the impact on HACE remains be elucidated. The present study...
Cerebral edema (CE) exerts an important effect on brain injury after traumatic (TBI). Upregulation of transient receptor potential melastatin 4 (TRPM4) in vascular endothelial cells (ECs) results damage to capillaries and the blood-brain barrier (BBB), which is critical for development CE. Many studies have shown that 9-phenanthrol (9-PH) effectively inhibits TRPM4. The current study aimed investigate 9-PH reducing CE TBI. In this experiment, we observed markedly reduced water content, BBB...
This study's objective is to assess the efficacy and safety of Pulsed Magnetic Therapy System (PMTS) in improving insomnia disorder.Participants with disorder were randomly assigned receive either PMTS or sham treatment for four weeks (n= 153; PMTS: 76, sham: 77). Primary outcomes are Insomnia Severity Index (ISI) scores at week 0 (baseline), 1, 2, 3, 4 (treatment), 5 (follow-up). Secondary Pittsburgh Sleep Quality baseline 4, weekly sleep diary-derived values latency, efficiency, real time,...
Abstract Background Sulfonylurea receptor-1(Sur1) and transient receptor potential melastatin 4(Trpm4) are implicated in acute brain injury. We determine whether serum Sur1 Trpm4 concentrations associated with spontaneous intracerebral hemorrhage(ICH) related perihematomal edema(PHE) clinical outcome after ICH. Methods Serum were measured 51 healthy controls patients modified Rankin Scale (mRS) score non-contrast computed tomography (NCCT) recorded to assess edema (PHE) severity. Modified...