- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Wound Healing and Treatments
- Electrohydrodynamics and Fluid Dynamics
- Micro and Nano Robotics
- Advanced Materials and Mechanics
- Surface Modification and Superhydrophobicity
- Pickering emulsions and particle stabilization
- Microfluidic and Bio-sensing Technologies
- Nanoplatforms for cancer theranostics
- Conducting polymers and applications
- Advancements in Transdermal Drug Delivery
- Pancreatic function and diabetes
- Hydrogels: synthesis, properties, applications
- Silk-based biomaterials and applications
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- Additive Manufacturing and 3D Printing Technologies
- Electrowetting and Microfluidic Technologies
- Photonic Crystals and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
Zhejiang Lab
2021-2025
University of Chinese Academy of Sciences
2021-2025
Nanjing Drum Tower Hospital
2020-2024
Southeast University
2015-2024
Åbo Akademi University
2022-2024
State Key Laboratory of Digital Medical Engineering
2015-2024
First Affiliated Hospital of Wenzhou Medical University
2019-2024
Wenzhou Medical University
2019-2024
Turku Centre for Computer Science
2023
University of Turku
2023
Structural color materials from existing natural organisms have been widely studied to enable artificial manufacture. Variable iridescence has attracted particular interest because of the displays various brilliant examples. Existing synthetic, variable, structural require external stimuli provide changing displays, despite autonomous regulation being widespread among organisms, and therefore suffer inherent limitations. Inspired by mechanism chameleons, we present a conceptually different...
Abstract Inspired by the coordinated multiple healing mechanism of organism, a four‐armed benzaldehyde‐terminated polyethylene glycol and dodecyl‐modified chitosan hybrid hydrogel with vascular endothelial growth factor (VEGF) encapsulation are presented for efficient versatile wound healing. The is formed through reversible Schiff base possesses self‐healing capability. As dodecyl tails can insert themselves into be anchored onto lipid bilayer cell membrane, has outstanding tissue adhesion,...
Helical objects are among the most important and landmark structures in nature, represent an emerging group of materials with unique spiral geometry; because their enriched physical chemical properties, they can have multiple functionalities. However, fabrication such complex helical at micro- or nanoscale level remains a challenge. Here, coaxial capillary microfluidic system, functions consecutive spinning spiraling, is presented for scalable generation microfibers. The processes be...
Infrared light, more than 50% of the solar light energy, is long-termly ignored in photocatalysis field due to its low photon energy. Herein, infrared-light-responsive photoinduced carriers driver first constructed taking advantage pyroelectric effect for enhancing photocatalytic hydrogen evolution. In order give full play role, reaction localized on surface and interface composite based a new semi-immersion type heat collected microfiber system. The system consisted distinctive substrate...
Abstract The rapid progress in flexible electronic devices has attracted immense interest many applications, such as health monitoring devices, sensory skins, and implantable apparatus. Here, inspired by the adhesion features of mussels color shift mechanism chameleons, a novel stretchable, adhesive, conductive structural film is presented for visually electronics. generated adding carbon nanotubes polydopamine (PDA) filler into an elastic polyurethane (PU) inverse opal scaffold. Owing to...
Natural fiber systems provide inspirations for artificial spinning and applications. Through a long process of trial error, great progress has been made in recent years. The natural itself, especially silks, the formation mechanism are better understood, some essential factors implemented methods, benefiting from advanced manufacturing technologies. In addition, fiber-based materials produced via bioinspired methods find an increasingly wide range biomedical, optoelectronic, environmental...
Patches with the capacity of controllable delivering active molecules toward wound bed to promote healing are expectant all along. Herein, a novel porous metal-organic framework (MOF) microneedle (MN) patch enabling photothermal-responsive nitric oxide (NO) delivery for promoting diabetic is presented. As NO-loadable copper-benzene-1,3,5-tricarboxylate (HKUST-1) MOF encapsulated graphene (GO), resultant NO@HKUST-1@GO microparticles (NHGs) imparted feature near-infrared ray (NIR) photothermal...
Niacin metal-organic frameworks (MOFs) encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfluidic electrospray approach for wound healing. As the bacteria-responsively degradable, niacin MOFs could intelligently, controllably, programmably release calcium, copper, zinc ions, depending on degree of infections. The released ions not only kill microbes destroying their membrane inducing outflow nutrient substance, but...
Microneedles have attracted increasing interest among various medical fields due to their painless, noninvasive, and efficient way of drug delivery. However, practical applications these microneedles in different epidermal locations environments are still restricted by low adhesion poor antimicrobial activity. Here, inspired the antibacterial strategy Paenibacillus polymyxa mechanisms mussel byssi octopus tentacles, we develop hierarchical with multifunctional adhesive abilities. With...
Three-dimensional (3D) bioprinting has been extensively explored for tissue repair and regeneration, while the insufficient nutrient oxygen availability in printed constructs, as well lack of adaptive dimensions shapes, compromises overall therapeutic efficacy limits their further application. Herein, inspired by natural symbiotic relationship between salamanders algae, we present novel living photosynthetic scaffolds using an situ microfluidic-assisted 3D strategy adapting irregular-shaped...
Abstract Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, highly designable capacity, HA hydrogels have been emerging biomaterial, showing tailoring performance in terms modifications hydrogel forms. Various preparation technologies developed the fabrication unique...
Abstract Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most them still lack satisfactory controllability comprehensive functionality. Herein, inspired by multiple creatures, including octopuses snails, a novel muti‐functional patch is presented with controlled adhesion, antibacterial, drug release features, monitoring functions for intelligent healing management. The micro suction‐cup actuator array tensile backing layer...
The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for regeneration. Herein, inspired the composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) regeneration presented. With help microfluidic-assisted 3D printing technology, composition and structure can be accurately controlled to meet clinical requirements. combination skin GelMa PP also endowed...
Abstract The management of infected wounds is always great significance and urgency in clinical biomedical fields. Recent efforts this area are focusing on the development functional wound patches with effective antibacterial, drug delivery, sensor properties. Here, we present novel hyaluronic acid (HA) microneedle these features by encapsulating aminobenzeneboronic acid‐modified gold nanoclusters (A‐GNCs) for management. A‐GNCs loaded were derived from negative‐mold replication showed high...
Morpho butterflies are famous for their wings' brilliant structural colors arising from periodic nanostructures, which show great potential value fundamental research and practical applications. Here, a novel cellular mechanical visualizable biosensor formed by assembling engineered cardiac tissues on the butterfly wings is presented. The assembled cardiomyocytes benefit parallel nanoridges of can recover autonomic beating ability with guided orientation good contraction performance. As...
As an important characteristic of many creatures, structural colors play a crucial role in the survival organisms. Inspired by these features, intelligent color material with heterogeneous striped pattern and stimuli-responsivity fast self-assembly colloidal nanoparticles capillaries certain diameter range are presented here. The width, spacing, color, even combination stripe patterns can be precisely tailored adjusting parameters. Attractively, integration near-infrared (NIR) light...
The fabrication of heterogeneous microstructures, which exert precise control over the distribution different cell types within biocompatible constructs, is important for many tissue engineering applications. Here, bioactive microfibers with tunable morphologies, structures, and components are generated employed creating constructs. Multibarrel capillary microfluidics multiple laminar flows used continuously spinning these microfibers. With an immediate gelation reaction dispersed alginate...
Abstract Considerable efforts have been devoted to developing artificial micro/nanomotors that can convert energy into movement. A flow lithography integrated microfluidic spinning and spiraling system is developed for the continuous generation of bioinspired helical micromotors. Because processes could be precisely tuned by adjusting rates illuminating frequency, length, diameter, pitch micromotors were highly controllable. Benefiting from fast online gelation polymerization, resultant...
Vitamin MOF-laden microfibers with alginate shells and copper- or zinc-vitamin framework cores are controllably generated for improving tissue wound healing.
Heterostructured microfibers with spindle-knots and joints are developed using a novel microfluidic technology, which enables integrative microfiber joint spinning, fluid coating, knot emulsification. The knots emulsification process can be precisely tunable by adjusting the flow rates. In this way, size spacing of achieved high controllability. More attractively, construction benefits from broad availability coating fluids, determines compositions knots. Thus, resultant imparted distinctive...