Osteoarthritis (OA) is a prevalent degenerative disease that afflicts more than 250 million people worldwide, impairing their mobility and quality of life. However, conventional drug therapy palliative. Exosomes (Exo), although with the potential to fundamentally repair cartilage, face challenges in efficient enrichment delivery. In this study, we developed magnetic polysaccharide hydrogel particles as microcarriers for synergistic OA. The were composed modified natural polysaccharides,...

With the accelerated aging tendency, osteoarthritis (OA) has become an intractable global public health challenge. Stem cells and their derivative exosome (Exo) have shown great potential in OA treatment. Research this area tends to develop functional microcarriers for stem cell Exo delivery improve therapeutic effect. Herein, we a novel system of Exo-encapsulated cell-recruitment hydrogel from liquid nitrogen-assisted microfluidic electrospray Benefited advanced droplet generation...

By combining optical absorption contrast and acoustic resolution, photoacoustic imaging (PAI) has broken the barrier in depth for high-resolution imaging. Meanwhile, Fluorescence (FLI), owing to advantages of high sensitivity specificity with abundant fluorescence agents proteins, always been playing a key role live animal studies. Based on different mechanisms, PAI FLI can provide important complementary information each other. In this work, we uniquely designed Photoacoustic-Fluorescence...

Immunotherapy plays a vital role in cancer postoperative treatment. Strategies to increase the variety of immune cells and their sustainable supply are essential improve therapeutic effect cell-based immunotherapy. Here, inspired by tertiary lymphoid structures (TLSs), we present microfluidic-assisted microporous annealed particle (MAP) scaffold for persistent recruitment diverse therapy. Based on thermochemical responsivity gelatin methacryloyl (GelMA), MAP was fabricated physical...

SignificanceVarious peripheral vascular diseases (PVD) in extremities, such as arterial atherosclerosis or venous occlusion arm legs, are a serious global health threat. Noninvasive imaging is of great value for both diagnosis and assessment PVD.ApproachBy scanning one-dimensional non-focusing linear array, an equivalent large two-dimensional (2D) matrix array with hundreds thousands more ultrasound elements formed, thereby achieving wide signal reception angle well area three-dimensional...

Although the transducer array-based photoacoustic tomography (PAT) system provides fast imaging speed, its high cost and complexity hinder implementations. In this Letter, for first time, to best of our knowledge, electrical slip ring was used develop a PAT that compromises speed. This enables using multiple transducers image target simultaneously continuously. addition, it is versatile use different transducers. The performance has been demonstrated by both phantom in vivo animal experiments.

Photoacoustic imaging (PAI) uniquely combines optics and ultrasound, presenting a promising role in biomedical as non-invasive label-free technology. As the traditional opaque ultrasound (US) transducers could hinder transportation of excitation light limit performance PAI system, piezoelectric transparent ultrasonic (TUTs) with indium tin oxide (ITO) electrodes have been developed to allow transmission through transducer illuminate sample directly. Nevertheless, without having matching...

Abstract In the field of structural health detection, since sensor needs to be directly bonded measured object, it is difficult stably transmit RFID information and realize passive wireless structure strain detection. To circumvent these difficulties, this paper innovatively proposes a dual-resonant circular microstrip patch antenna (CMPA) with chipless tag. The tag can changed that allows deployed on large scale. separating includes layer CMPA layer, which simultaneously reflect...

Photoacoustic microscopy (PAM) and optical coherence tomography (OCT) are sensitive to absorption scattering characteristics, respectively. As such, the integration of these two modalities in order combine important complementary information has garnered much attention. Due relatively low axial resolution PAM, PAM OCT dual modality systems generally have a large gap, especially for reflection mode systems. In this study, based on wide-band transparent pure-optical ultrasonic detector, we...

The prestress loss is one of the main factors affecting safety prestressed concrete structure. While detecting signals like sound and light are difficult to spread in steel strands, there no effective method for detection bonded strands existing structures yet. In this paper, taking into consideration that electromagnetic oscillation characteristic can make signal propagate effectively on a nondestructive based effect detect frequency proposed. circuit, simulated as an inductance component,...

The detection of chipless radio frequency identification (RFID) tags is mostly realized by vector network analyzers. In actual detection, this method expensive and not flexible enough. A new implemented on the Universal Software Radio Peripheral (USRP) proposed in article. measurement object a 6-bit RFID coded tag sensor based spiral resonator trap circuit. power function band designed USRP's open-source platform GNU Radio. On basis, for with spectrum coding, decoding maximum-likelihood...

In this study, we reported a photoacoustic (PA) imaging system for whole-breast imaging. Similar to the traditional X-ray mammography, slightly compressed breast by water tank. The PA signal is acquired via scanning long unfocused ultrasonic linear array probe over top surface, and expanded high-energy laser pulses illuminate bottom through transparent supporting plate. Scanning transducer equivalent synthetic two-dimensional (2D) matrix array, which significantly increased field of view...

Since the dark-field acoustic-resolution photoacoustic microscopy (AR-PAM) was invented over one decade ago, its powerful imaging capability made this system successful. In work, we designed and tested an AR-PAM whose key parts are relied on 3D printing fiber bundles. This new design not only makes it much simpler to develop a robust PAM system, but also illumination angle is adjustable aid for different applications. Our simulation study phantom experiments demonstrated that has comparable...

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Although ultrasound transducers based on commercial piezoelectric-material have been widely used, they generally limited bandwidth centered at the resonant frequency. Currently, several pure-optical ultrasonic detection methods gained increasing interest due to their wide and high sensitivity. However, most of them require customized components (such as micro-ring, SPR, Fabry-Perot film, etc), which limit broad implementations. In this study, we presented a simple method, called...