Medical patches play an important role in wound healing because of their tissue conformality, drug release capacity, and convenient operation. Great efforts have been devoted to developing new-generation with distinctive features promoting healing. Here, inspired by the structure octopus suction cups component natural tissue, a biocompatible patch selective adhesiveness individualized design using combined strategy template-replication mask-guided lithography is presented. Such are based on...

Abstract Many hydrogel patches are developed to solve the pervasive and severe challenge of complex wound healing, while most them still lack satisfactory controllability comprehensive functionality. Herein, inspired by multiple creatures, including octopuses snails, a novel muti‐functional patch is presented with controlled adhesion, antibacterial, drug release features, monitoring functions for intelligent healing management. The micro suction‐cup actuator array tensile backing layer...

Directional transport of liquids is great importance in energy saving, chemical/biomedical engineering, and microfluidics applications. Despite considerable progress engineering different open surfaces to achieve liquid manipulation, the realization diode-like enclosed spaces still challenging. Here, a flexible diode microtube presented for directional within confined using pulsed microfluidics. The microtubes exhibit sophisticated microstructures on inner wall, replicated from precisely...

Biological scaffolds have been widely employed in wound healing applications, while their practical efficiency is compromised by insufficient oxygen delivery to the 3-dimensional constructs and inadequate nutrient supply for long-term process. Here, we present an innovative living Chinese herbal scaffold provide a sustainable promoting healing. Through facile microfluidic bioprinting strategy, traditional medicine ( Panax notoginseng saponins [PNS]) autotrophic microorganism (microalgae...

Abstract Wound healing remains a critical challenge in regenerative engineering. Great efforts are devoted to develop functional patches for wound healing. Herein, novel sprayable black phosphorus (BP)‐based multifunctional hydrogel with on‐demand removability is presented as joints’ skin dressing. The facilely prepared by mixing dopamine‐modified oxidized hyaluronic acid, cyanoacetategroup‐functionalized dextran containing phosphorus, and the catalyst histidine. catechol‐containing dopamine...

Reproduction is the most important event for continuation of life. Unfortunately, infertility a widespread problem. Recently, biomaterials have been widely used in reproductive biology, including tissue engineering, regenerative medicine and contraception. In this review, we summarize research progress applied follicle culture, artificial ovary, We first introduce applications advantages different culture ovary. Then, engineering biology. Also, Besides, some emerging technologies are also...

Wound healing introduces a series of interesting challenges in healthcare, such as open wounds, burn and chronic infection wounds. Hence more accurate effective biomedical materials are expected, for which emerging hydrogels with unique excellent properties have demonstrated great potential. When they applied wound dressings, tissue patches, plugging agent, drug carriers, biosensors, etc., there urgent requirements adhesive capabilities. The existence interfacial water, soft moving surfaces,...

Abstract Stem‐cell‐based therapeutic strategies are promising in the clinical treatment of intrauterine adhesions (IUAs), while endometrial regeneration still hardly restores structure and function endometrium because inadequate microenvironment for grafted stem cells subsequent limited efficiency. Herein, an injectable porous hydrogel scaffold (PH scaffold) with customizable shapes is presented by using a microfluidic‐based 3D printing technique adipose‐derived (ADSCs) delivery to enhance...

Magnetically recyclable Hoveyda–Grubbs catalyst can be readily assembled using magnetic nanoparticles as support, and this combines convenient recyclability excellent activity on ring-closing metathesis (RCM) reactions.

Abstract Bioengineered nerve conduits have shown great promise for spinal cord injury (SCI) repair, while their practical values are limited by poor regenerative efficacy and lack of multi‐level structural design. Here, inspired the ingenious anatomy natural cords, a biomimetic multichannel silk conduit (namely BNC@MSCs/SCs) with multicellular spatiotemporal distributions effective SCI repair is presented. The (BNC) hierarchical channels aligned pore structures prepared via modified...

Abstract Bone defect is a common clinical orthopedic disease. The trend in this field to develop tissue engineering scaffolds with appropriately designed components and structures for bone repair. Herein, inspired by the organic inorganic of matrix natural biomineralization mechanism, MgSiO 3 @Fe O 4 nanoparticle composite polycaprolactone (PCL) hybrid mineralized scaffold repair developed microfluidic 3D printing. incorporation within PCL can effectively improve bioactivity. In addition,...

Abstract Constructing hydrogels with spatially heterogeneous structures are crucial for unlocking novel applications. To this end, selectively removing a specific portion of by facile and intricate destructive strategies is worth exploring. Herein, “contact‐destructive” hydrogel actuator presented, composed dynamic network doped hydrophilic polyethylene glycol (PEG). The behavior the attributed to surface tension‐induced spreading effect enhanced water absorption due additive PEG. Parameters...

Nephropathy associated metabolic disorder induces high incidence of fragility fracture in end-stage renal disease (ESRD) patients. As the risk factors and prognosis ESRD patients are unclear, more research is needed. This study aimed to evaluate various for ESRD-related fractures, explore affecting with such provide information prevention treatment osteopathy improve patients.In this retrospective case-control study, case notes 521 who received maintenance dialysis at least 3 months were...

To deal with intra-abdominal sepsis, one of the major global causes death in hospitalized patients, efficient abscess drainage is crucial. Despite decades advances, traditional catheters have demonstrated poor and absorption properties due to their simple tubular structures dense nonporous surface. Herein, inspired by porous sponges fractal roots, a multifaceted hydrogel catheter effective drainage, absorptive, robust properties, presented. Its unique provide extensive internal branching...

Abstract Localized chemotherapy is emerging as a potential strategy for cancer treatment due to its low systemic toxicity. However, the immune evasion of tumor cells and lack an intelligent design delivery system limit clinical application. Herein, photothermal responsive microcarriers are designed by microfluidic electrospray colorectal treatment. The loaded with Cangrelor, 5‐FU MXene (G‐M@F/C+NIR) show sustained antiplatelet drug thus inhibiting activity platelets, interactions...

There is no clear consensus on the optimal endovascular treatment strategy for patients with ischemic stroke caused by ICAS-related large vessel occlusion (LVO). SPACEMAN, a novel thrombectomy technique that entails passing an aspiration catheter over stent retriever and then retaining microwire angioplasty, has not been described. The aim of this prospective study was to evaluate our initial application SPACEMAN compare Solumbra technique.Forty-four consecutive acute resulting from LVO were...

Objectives We investigated how device-measured physical activity (PA) volume (PA energy expenditure [PAEE]) and intensity (fraction of PAEE from moderate-to-vigorous PA [FMVPAEE]) were associated with the incidence type 2 diabetes mellites (T2DM). Methods This population-based prospective cohort study included 90,044 participants. The primary exposures FMVPAEE. secondary exerted during light, moderate, vigorous their fraction PAEE. Results Each 1-SD increase in was a 17% lower risk T2DM...