A5083958797- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Luminescence Properties of Advanced Materials
- Nanocluster Synthesis and Applications
- Electrochemical sensors and biosensors
- Inhalation and Respiratory Drug Delivery
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Electrospun Nanofibers in Biomedical Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Electrohydrodynamics and Fluid Dynamics
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrochemical Analysis and Applications
- Cancer Cells and Metastasis
- Advancements in Transdermal Drug Delivery
- Mass Spectrometry Techniques and Applications
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Synthesis and Properties of Aromatic Compounds
Chinese Academy of Sciences
2013-2025
Institute of High Energy Physics
2013-2025
University of Chinese Academy of Sciences
2021-2024
Zhejiang Lab
2021-2024
Wenzhou University
2024
National Center for Nanoscience and Technology
2017-2022
Wenzhou Medical University
2021
State Council of the People's Republic of China
2019
Beijing Normal University
2008-2009
Xiamen University
1998-2007
Here, dual-modal bioprobes for combined optical and magnetic resonance (MR) imaging are reported. Gadolinium orthophosphate (GdPO(4)) nanorods co-doped with light-emitting lanthanide ions have been successfully prepared through a hydrothermal method. An efficient downconversion luminescence from Ce/Tb or Eu doped GdPO(4) upconversion Yb/Er observed, respectively, which offers the modality nanoprobes. Notably, we first report phenomenon based on matrix under 980 nm near infrared irradiation....
Abstract Molybdenum (Mo), as a nontoxic and low‐cost transition metal, has been employed for synthesis of various Mo‐based nanomaterials with unique structures physicochemical features to achieve properties. Especially, bioinspired show great potential the construction novel nanozyme catalysts due their variable oxidation states. Overcoming drawbacks natural enzymes, nanozymes not only provide effective catalytic sites or multivalent elements mimic but also present multiple functions...
When organs, especially external organs are injured, pathogens and excessive water loss can threaten the wound healing process cause local irreversible tissue damage. Here, novel natural κ-Carrageenan microparticles (MPs) able to deliver bioactive proteins small molecules surface for promoted regeneration were developed using microfluidic electrospray. The side chains of modified with methacrylate pendant groups make monomer photonic cross-linkable. By changing concentration...
Abstract Stem cells have demonstrated values in diabetic ulcer (DU) treatments. Challenges this area are focused on enhancing the localized curative effects of stem and improving wound healing efficiently. Herein, a novel living microneedle (MN) patch is presented as delivery system bioactive platelet derived growth factor D (PDGF‐D) human adipose‐derived (ADSCs) for DU treatment. Compared with traditional complicated cell carriers, MN can keep viability ADSCs encapsulation delivery,...
Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity metabolism vivo. In this study, we chose polyethyleneimine modified NaYF4:Yb,Er upconversion (abbreviated as PEI@UCNPs) systematically study biodistribution mice using intravenous (i.v.), intraperitoneal (i.p.), intragastric (i.g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation spleen within 30 days. Comparably,...
The level of tumor killing by bismuth nanoparticles (BiNPs) as radiosensitizers depends strongly on the powerful particle-matter interaction. However, this same radiation leads to structural damage in BiNPs, consequently weakening their specific physicochemical properties for radiosensitization. Herein, we studied radiation-induced corrosion behavior BiNPs and demonstrated that these damages were manifested change morphology crystal structure well self-oxidation at surface. Furthermore,...
A simple two-step strategy based on gas expansion combined liquid exfoliation to synthesize defect-rich N-doped MoS<sub>2</sub> and WS<sub>2</sub> nanosheets (NSs) was proposed. The NSs with improved peroxidase-like catalytic activity can be applied as effective nanoantimicrobials.
Bacterial infection has been a great threat to wounds due the abuse of antibiotics and drug resistance. Elaborately constructing an efficient antibacterial strategy for accelerated healing bacteria-infected is importance. Herein, we develop transferrin-conjugated copper peroxide nanoparticle-hydrogel (denoted as CP@Tf-hy) wound dressing with no toxicity mammalian cells at test dosage. When exposed initial acidic environment, CP@Tf-hy simultaneously displays in situ self-supplied H2O2...
Abstract Stem‐cell‐based therapeutic strategies are promising in the clinical treatment of intrauterine adhesions (IUAs), while endometrial regeneration still hardly restores structure and function endometrium because inadequate microenvironment for grafted stem cells subsequent limited efficiency. Herein, an injectable porous hydrogel scaffold (PH scaffold) with customizable shapes is presented by using a microfluidic‐based 3D printing technique adipose‐derived (ADSCs) delivery to enhance...
Abstract Exosomal microRNAs have been studied as a good source of noninvasive biomarkers due to their functions in genetic exchange between cells and already well documented many biological activities; however, inaccuracy remains key challenge for liver cancer surveillance. Herein, versatile duplex photothermal digital polymerase chain reaction (PCR) strategy combined with lipid nanoparticle‐based exosome capture approach is proposed profile expression through 3‐h easy‐to‐operate process....
With the rapid development of nanotechnology, nanomaterials have shown immense potential for antitumor applications. Nanosized calcium carbonate (CaCO3) materials exhibit excellent biocompatibility and degradability, been utilized to develop platform technologies cancer therapy. These can be engineered carry anticancer drugs functional groups that specifically target cells tissues, thereby enhancing therapeutic efficacy. Additionally, their physicochemical properties tailored enable...
Abstract Abnormal H 2 O and cholesterol levels are closely related to many diseases. This work reports a facile process for the synthesis of oxidized glutathione (GSSG)‐modified MoS nanosheets (MoS ‐GSSG NSs). The biocompatible NSs have good dispersibility high affinity substrate 3,3′,5,5′‐tetramethylbenzidine (TMB), which is beneficial improving peroxidase‐like catalytic activity . was applied as robust nanoplatform low‐cost, rapid, highly effective colorimetric detection total/free...
Liver plays a critical role in drug metabolism and nowadays multi-cellular culture systems aiming at imitating liver-specific morphology functionality are advancing robustly. Numerous immortalized or stem cell-induced hepatic cell lines have been investigated to enhance the phenotype establishing co-culture systems. Owing robust progresses of microtechnology bioengineering, two-dimensional (2D) co-cultures such as sandwich micropatterned emerged. Controllably arranging hepatocytes...
Wounds infected with drug-resistant bacteria are hard to treat, which remains a serious problem in clinical practice. An innovative strategy for treating wound infections is thus imperative. Herein, we describe the construction of nanocomposite from biocompatible poly(vinyl alcohol) (PVA)/polyethylene glycol (PEG) hydrogel loaded biodegradable MoO
A film with elaborate microstructures that offers biomimetic properties and multi functionalities is highly desired in wound healing. Here, we develop an aligned hydrogel fiber integrated multi-active constituents to promote Such films are designed constructed by photo-crosslinking the methacrylate gelatin (GelMA) doped silver nanoparticles (Ag NPs) iridium coated polyvinylpyrrolidone (PVP-Ir precursor solution using electrospinning. The nature of GelMA arrangement nanofibers endow...
Epithelium and endothelium, occupying a significant proportion of cells in the human body, play crucial role maintaining organs' normal structure function. Various methods have been employed to study physiology pathology epithelium endothelium. However, these conventional methods, such as animal trials two-dimensional (2D) cell culture, fail precisely simulate complex biology body due species difference lack native microenvironment systems, which is essential for culture. To overcome...
The early detection of procalcitonin (PCT) is crucial for diagnosing bacterial infections due to its high sensitivity and specificity. While colloidal gold colorimetric immune-chemiluminescence methods are commonly employed in clinical detection, the former lacks sensitivity, latter faces challenges with a brief luminescence process an elevated background. Here, we introduce novel approach quantitative analysis PCT using surface-enhanced Raman spectroscopy (SERS), leveraging enhanced...
Tumor recurrence and tissue regeneration are two major challenges in the postoperative treatment of cancer. Current research hotspots focusing on developing novel scaffold materials that can simultaneously suppress tumor promote repair. Here, we propose a microfluidic 3D-printed methacrylate fish gelatin (F-GelMA@BBR) loaded with berberine (BBR) for gastric The F-GelMA@BBR displayed significant killing effect cancer MKN-45 cells vitro demonstrated excellent anti-recurrence efficiency models....