A5103042359- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Anomalies and Fetal Surgery
- Gallbladder and Bile Duct Disorders
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phagocytosis and Immune Regulation
- Renal and related cancers
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Intestinal Malrotation and Obstruction Disorders
- Amoebic Infections and Treatments
Sun Yat-sen University
2008-2023
The First Affiliated Hospital, Sun Yat-sen University
2008-2023
Erythroblastic islands (EBIs) are the specialized structures for erythropoiesis, but they have never been found functional in tumors. As most common pediatric liver malignancy, hepatoblastoma (HB) requires more effective and safer therapies to prevent progression lifelong impact of complications on young children. However, developing such is impeded by a lack comprehensive understanding tumor microenvironment. By single-cell RNA sequencing 13 treatment-naive HB patients, we discover an...
Background: Postoperative cholangitis is a common but severe complication after Kasai portoenterostomy for biliary atresia (BA).This study aimed to identify its prognostic factors.Methods: Two sets of liver paraffin-embedded tissue samples were collected from BA patients who received (n = 25 and n 31, respectively).Patients divided into non-cholangitis groups.The infiltration CD4 + , CD8 CD45RO CD68 cells expression Beclin1 quantitatively evaluated in immunohistochemical analysis.Results:...
Objective To summarize the experience of diagnosis and treatment intrahepatic biliary cysts(IBCs)in children with atresia after portoenterostomy in order to analyze influence IBCs on prognosis patients atresia(BA).Methods The BA who underwent were followed up from June 1998 March 2008.Ultrasonography showed cystic dilatation system 8 cases.In abovementioned cases,three diagnosed by MRI six CT enhancement scanning.All had symptoms cholangitis postoperatively.Five them PTCD 3 operation...
Objective To evaluate the effects of cholangitis after hepatic portoenterostomy for biliary atresia on long term survival.Methods 92 patients with admhted into First Affiliated Hospital Sun Yat-Sen University in-patients between March 1 989 tO 1997 underwent Kasai procedure were reviewed.The clinical data including age.operation methods and post-operative cholangitis,were analyzed.Results The patients' age ranged from 30 days to 137 days.There 55 boys 37 girls.The oldest patient was 19 years...
Abstract Background: This study aimed to report our 10-year experiences on the treatment of recurrent Wilms tumor (WT) improve therapeutic outcome WT in China. Patients and Methods: From August 2006 2017, 14 patients (7 males 7 females) with Wilms’ treated at center were included. Their medical records reviewed. Results: Primary mainly diagnosed age 1-3 years (50%). The main histology primary was unclassified types (42.9%), followed by blastemal (35.7%). Four cases did not receive...