Background Rosacea, a chronic inflammatory skin disorder etiologically associated with immune cells and the antibacterial peptide cathelicidin LL-37, can be effectively treated by oral carvedilol administration. Objective To investigate molecular mechanisms underlying efficacy in rosacea treatment. Methods Skin samples of patients were subjected to histopathological (hematoxylin eosin) immunohistochemical (CD68, Toll-like receptor 2 (TLR2), kallikrein 5, cathelicidin, TNF-α, IL-1β)...

The objective of this study is to compare the effectiveness low-load blood flow restriction training (LL-BFRT) heavy-load resistance (HL-RT) in male collegiate athletes with chronic non-specific low back pain (CNLBP). Twenty-six participants were randomly assigned LL-BFRT (n = 13) or HL-RT 13). All supervised exercises (deep-squat, lateral pull-down, bench-press and machine seated crunch) cycled 4 times per week for weeks (16 sessions). was done at 30% 1-repetition maximum (1RM) 70% arterial...

Background: Geniposide, a prominent iridoid glycoside derived from Gardenia jasminoides J . Ellis, has garnered attention due to its association with hepatotoxicity despite well‐documented pharmacological efficacy in preclinical and clinical contexts. The NOD‐like receptor protein 3 (NLRP3) inflammasome is implicated numerous pathological conditions, including drug‐induced liver injury. This study aims explore the involvement of NLRP3 geniposide‐induced toxicity. Methods: Rats were...

Traumatic spinal cord injury (TSCI) induces a powerful inflammatory response that can significantly exacerbate the extent and severity of neural damage (termed as "secondary injury"). Thus, suppression inflammation is crucial for reducing neurological dysfunction following TSCI. However, conventional anti-inflammatory drugs show limited efficacy because poor penetration release kinetics at site. This study describes design, synthesis, kinetics, biosafety, preclinical minocycline (MC)-loaded...

Abstract Objectives Observational studies indicated a controversial relationship between periodontitis (PD) and Sjogren’s syndrome (SS). To overcome restrictions in conventional observational studies, we conducted two-sample Mendelian randomization (MR) analysis to assess the potential bidirectional PD SS. Methods We utilized largest available genome-wide association study (GWAS) of European ancestry on both (17,353 cases-28,210 controls) SS (2495 cases-365,533 for MR genetic instrument...

The aim was to determine the effect of electron beam (EB) irradiation on IgE binding capacity shrimp tropomyosin (TM) at frozen stage. Following EB irradiation, protein extracts were characterized by sodium dodecyl sulfate–polyacrylamide gel electrophoresis and TM degradation observed. degradations further recognized from a shrimp-allergic patient immunoblots. Specific results showed that initially increased 10% after 3 kGy doses, then decreased 20% with doses 10 kGy. Further inhibition...

This study aimed to build an indepth and comprehensive understanding of the social maladaptation experience Chinese children with leukaemia different ages. The purposive sampling method was adopted conduct semistructured interviews 20 or their main caregivers Colaizzi's for qualitative research used organise analyse data. followed guiding principles Standards Reporting Qualitative Research. existing adaptation problems ages were assessed. In terms psychological maladjustment, aged 2-7 years...

This article proposes a novel semi-supervised competitive learning (SSCL) algorithm for vocal pattern classifications in Parkinson’s disease (PD). The acoustic parameters of voice records were grouped into the families jitter, shimmer, harmonic-to-noise, frequency, and nonlinear measures, respectively. linear correlations computed within each parameter family. According to correlation matrix results, harmonic-to-noise presented as highly correlated terms Pearson’s coefficients. Then,...

The well-prepared endometrium with appropriate thickness plays a critical role in successful embryo implantation. thin is the main factor of frozen-embryo transfer (FET), resulting failure implantation undergoing FET. Hormone treatment suggested to improve thickness; however, among larger numbers cases, it cannot reach sufficient thickness, which leads high cancelation rate as well waste high-quality embryos. Thus, increases burden patients both economic and psychological perspectives. We...

Background The etiopathogenesis of periodontitis is closely associated with environmental conditions. However, the relationship between ethylene oxide exposure and risk remains unclear. Methods We selected qualified participants from National Health Nutrition Examination Survey (NHANES) 2013–2014. Periodontitis was identified according to criteria Community Periodontal Index (CPI), Centers for Disease Control Prevention (CDC)/American Academy Periodontology (AAP) definition. Ethylene...

Abstract Purpose Interventional Cone‐Beam CT (CBCT) offers 3D visualization of soft‐tissue and vascular anatomy, enabling guidance abdominal interventions. However, its long acquisition time makes CBCT susceptible to patient motion. Image‐based autofocus a suitable platform for compensation deformable motion in CBCT, but it relies on handcrafted metrics based first‐order image properties that lack awareness the underlying anatomy. This work proposes data‐driven approach quantification via...

Abstract Objective The aim at the current study was to investigate clinical characteristics and risk factors of Raynaud’s phenomenon (RP) in patients with primary Sjögren’s syndrome (pSS). Methods Retrospective analysis medical records 333 new-onset pSS performed. Demographic, clinical, serological data were compared between individuals without RP. Logistic regression used identify factors. Results RP present 11.41% patients. pSS-RP younger (49.74±14.56 years vs. 54.46±13.20 years, p =0.04)...

Abstract Background Facial erythema, a prominent characteristic of rosacea, causes concern to both the patient and doctor. In clinical practice, commonly used erythema severity subjective assessment tools lack objectivity are less comprehensive. Even with images taken by VISIA ® system, diffused is difficult segment evaluate fully due automatic threshold segmentation method. This study aimed explore more objective scientific quantification tool aid ImageJ software analysis red area system....

In March 2020, the World Health Organization (WHO) declared COVID-19 a pandemic, and spike protein has been reported to be an important drug target for anti-COVID-19 treatment. As such, in this study, we successfully developed novel electrochemical receptor biosensor by immobilizing SARS-CoV-2 using AuNPs-HRP as signal amplification system. Moreover, time-current method was used quantify seven antiviral compounds, such arbidol chloroquine diphosphate. The results show that drugs are linearly...

To determine immunohistochemical features and correlations between M1/M2 polarisation status with disease severity of post-caesarean scar diverticulum (CSD).Histological immunohistological stainings were performed inflammatory (CD16, CD163 tumour necrosis factor-α (TNF-α)), fibrosis (α-smooth muscle actin (α-SMA)) angiogenic (CD31) markers examined in uterine tissues collected from patients diverticula (CSD) (n=37) caesarean section (CS) (n=3).CSD have higher expression α-SMA, TNF-α, CD16...

Bioinformatics analysis of Gene Expression Omnibus (GEO).

Background Early natural menopause, characterized by the cessation of ovarian function before age 45, has been a subject prior research indicating that inflammation may predict onset menopause. However, specific relationship between peripheral blood inflammatory parameters and early menopause remains ambiguous. Methods This observational study utilized data from National Health Nutrition Examination Survey (NHANES) spanning years 2013–2018. The at was ascertained through Reproductive...

Objective To explore and analyze the menopause symptoms mental state of anxiety depression in patients with premature ovarian insufficiency (POI). Methods We collected from Department Obstetrics Gynecology, Renji Hospital, School Medicine, Shanghai Jiao Tong University January 2016 to May 2018, including 63 POI (POI group), 60 healthy aged 35-40 years as normal group (control group) 71 45-55 menopausal syndrome (MPS) experimental control (MPS at same time. We used Kupperman Menopausal...

To establish a nomogram prediction model for posttraumatic growth (PTG) in children aged 8-18 years with malignancies China and to convenient intuitively judge psychological tendencies.We recruited 358 as the study participants. Data from 250 cases collected June 2019 November were used group, data 108 December January 2020 validation group. Logistic regression was analyze influencing factors of PTG A then established using nomogram. The centrality measurement index(C-index) receiver...

Detection of phonation impairment is very useful for assessing the pathological progress patients with Parkinson's disease (PD) at early stages. In this paper, we first categorized acoustic parameters into several families jitter, shimmer, harmonic-to-noise, frequency, and nonlinear measures, analyzed linear correlation coefficients within each family. Then, utilized principal component analysis to reduce redundant dimensions different parameter families. The dominant projected features were...