A5016663417- Wound Healing and Treatments
- Cancer Immunotherapy and Biomarkers
- Connexins and lens biology
- Immune cells in cancer
- Virus-based gene therapy research
- Lymphoma Diagnosis and Treatment
- Heat shock proteins research
- Viral gastroenteritis research and epidemiology
- Cancer-related molecular mechanisms research
- Phagocytosis and Immune Regulation
- Hair Growth and Disorders
- Ion channel regulation and function
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- CRISPR and Genetic Engineering
- Hepatocellular Carcinoma Treatment and Prognosis
- Healthcare and Venom Research
- CAR-T cell therapy research
- Advanced Breast Cancer Therapies
- Animal Virus Infections Studies
- Asthma and respiratory diseases
- Thermal Regulation in Medicine
- Genetic and Kidney Cyst Diseases
- Nutrition, Health and Food Behavior
- Pressure Ulcer Prevention and Management
Chongqing University
2024-2025
Chongqing University of Technology
2025
University of Chicago
2025
Chinese Academy of Agricultural Sciences
2024
University of Ottawa
2014-2024
Sun Yat-sen University
2009-2024
Children's Hospital of Eastern Ontario
2014-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Tertiary lymphoid structures (TLSs) are associated with enhanced immunity in tumors. However, their formation and functions colorectal cancer liver metastasis (CRLM) remain unclear. Here, we reveal that intra- peri-tumor mature TLSs (TLS+) improved clinical outcomes than TLS- Using single-cell-RNA-sequencing spatial-enhanced-resolution-omics-sequencing (Stereo-seq), TLS+ tumors enriched IgG
PURPOSE: To compare two doses of letrozole (0.5 mg and 2.5 every day) megestrol acetate (40 qid) as endocrine therapy in postmenopausal women with advanced breast cancer previously treated antiestrogens. PATIENTS AND METHODS: This double-blind, randomized, multicenter, multinational study enrolled 602 patients, all whom were included the primary analysis protocol. Patients had or metastatic evidence disease progression while receiving continuous adjuvant antiestrogen therapy, experienced...
Depression may influence susceptibility to cancer, and the genes signaling pathways that mediate this association are unclear.Here, we used isobaric tagging for relative absolute quantitation, 2-dimensional liquid chromatography, mass spectrometry compare proteins expressed in hepatocellular carcinoma patients with or without depression.A total of 89 were up-regulated 44 down-regulated depression. HSP90AA1 HSPA8 up-regulated, which correlated elevated levels VEGF, VEGFR2, PI3K, AKT1 reduced...
Tissues maintain their function through interaction with microenvironment. During aging, both hair follicles and blood vessels (BV) in skin undergo degenerative changes. However, it is elusive whether the changes are due to intrinsic aging or respectively, interactions. To explore how interact regulate angiogenesis regeneration during aging. Single-cell RNA-sequencing (scRNA-seq) analyses were used identify declined ability of dermal papilla (DP) endothelial cells (ECs) CellChat CellCall...
Empirical evidence indicates that the rate of wound healing varies through different seasons, where it is higher in spring and fall but lower summer winter, suggesting adequate temperatures may promote via an unknown mechanism. Here we show temperature facilitates by inducing expression Elongation Very Long Chain Fatty Acid Elongase 4 (ELOVL4) curtails inflammation phase. Using skin injury organoids models, bulk- single-cell RNA-sequencing spatial transcriptomics analysis, vivo functional...
Introduction: Aging causes striking changes in the extracellular matrix (ECM) hair follicles, which has a profound influence on growth. How ECM of dermal papilla (DP), master regulator growth, during aging remains largely unknown. Methods: Herovici staining, Western Blotting and immunofluorescence were used to assess DP protein expression follicles. Bulk single cell RNA-sequencing analyze gene predict upstream downstream regulators target genes. Skin organoid mouse models for functional...
Abstract Background Obesity and obesity-related cancers contribute to rising healthcare costs declining life expectancy in the US improving diet quality plays a crucial role reversing such trends. Existing studies on relationship between healthy food access cancer mortality present mixed findings, whereas procurement activities are largely overlooked. The paper aims construct novel environment index based residents’ retailer visits, then compare it with location-based regarding strength of...
<title>Abstract</title> This study recalculates the modified Retail Food Environment Index (mRFEI) using 2018–2019 Infogroup dataset, addressing a data gap left since index’s last revision in 2011. The updated mRFEI is employed to assess current food access disparities United States. Based on recalculated mRFEI, we have evaluated evolution of inequities by examining relationships between and each theme community’s social vulnerability index (SVI) over decade. Our findings reveal that higher...
Erythroblastic islands (EBIs) are the specialized structures for erythropoiesis, but they have never been found functional in tumors. As most common pediatric liver malignancy, hepatoblastoma (HB) requires more effective and safer therapies to prevent progression lifelong impact of complications on young children. However, developing such is impeded by a lack comprehensive understanding tumor microenvironment. By single-cell RNA sequencing 13 treatment-naive HB patients, we discover an...
Mitophagy maintains tissue homeostasis by self-eliminating defective mitochondria through autophagy. How mitophagy regulates stem cell activity during hair regeneration remains unclear. Here, we found that promotes the proliferation of germ (HG) cells regulating glutathione (GSH) metabolism. First, single-cell RNA sequencing, mitochondrial probe, transmission electron microscopy, and immunofluorescence staining showed stronger increased mitophagy-related gene especially Prohibitin 2 (Phb2)...
The route of oncolytic virotherapy is pivotal for immunotherapeutic efficacy in advanced cancers. In this preclinical study, an reovirus (RC402) orally administered to induce antitumor immunity. Oral treatment shows no gross toxicities and effectively suppresses multifocal tumor lesions. Orally interacts with the host immune system Peyer's patch terminal ileum, increases IgA
Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. Translational control of mRNA is an important feature immunity, yet the identity translationally regulated mRNAs functioning host defense remains ill-defined. We report translatomes resistant murine "4T1" breast infected three most clinically advanced viruses: herpes simplex virus 1, reovirus, and vaccinia virus. Common among all infections are de-repressed mRNAs, including Inpp5e, encoding...
Abstract Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, is an aggressive cancer with a poor prognosis. Despite current management, 5-year survival rate for patients metastatic RMS ∼30%; underscoring need to develop better treatment strategies. We have recently reported that pannexin 1 (PANX1) levels are downregulated and restoring its expression inhibits progression. Here, we surveyed characterized molecular changes induced by PANX1 re-expression RMS. cataloged...
The mammalian reovirus Type 3 Dearing (T3D) is a naturally occurring oncolytic virus. We previously identified T3D variant isolated from persistently infected cancer cells that has premature stop codon mutation in the S1 gene, generating truncated σ1-attachment protein lacks globular head. now report on molecular characterization of this variant, named RP116, and assess its antitumor potential human syngeneic mouse models. RP116 replicates efficiently several cell lines, shows reduced...
Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma of childhood thought to arise from impaired differentiation skeletal muscle progenitors. We have recently identified Pannexin 1 (PANX1) channels as a novel regulator myogenesis. In the present study, we determined that PANX1 transcript and protein levels are down-regulated in embryonal (eRMS) alveolar RMS (aRMS) patient-derived cell lines primary tumor specimens compared differentiated myoblasts tissue, respectively. While not...
Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) down-regulated in RMS and increasing its levels drastically inhibits progression. PANX1 upregulation thus represents prospective new treatment strategy for this malignancy. However, the mechanisms regulating expression, other contexts, remain largely unknown. Here we show that both normal express comparable amount mRNAs, but surprisingly canonical 5' untranslated region (5' UTR) or leader transcript...
1087 Background: Breast cancer is the most common among women, with up to 37% of patients (pts) harboring germline BRCA1/2 mutations (g BRCA1/2m) that appear be sensitive poly (ADP-ribose) polymerase proteins 1 and 2 (PARP1/2) inhibition. Pamiparib an orally administered selective PARP1/2 inhibitor has potential cross blood-brain barrier. This study evaluated efficacy safety pamiparib in pts locally advanced/metastatic human epidermal growth factor receptor 2-negative (HER2-) breast cancer,...
Pannexin 1 (PANX1) is expressed in many tissue types including tissues of neural origin. Neuroblastoma (NB) a crest-derived malignancy mainly occurring children. The majority NB patients present with high-risk disease for which current therapies are ineffective. Here, we show that while PANX1 all stages, high expression associated reduced survival probability. channel inhibition using probenecid (PBN) or carbenoxolone (CBX) the proliferation our panel cell lines. We Y10F mutant, cannot be...
<title>Abstract</title> Empirical evidence indicates that the rate of wound healing varies through different seasons, where it is higher in spring and fall but lower summer winter, suggesting appropriate low temperatures may promote via an unknown mechanism. Here we discover such temperature which facilitates by stimulating long-chain fatty acid synthesis curtails inflammation. Using skin injury organoids models, single-cell RNA-sequencing spatial transcriptomics analysis, vivo functional...