A5074162245- Adipose Tissue and Metabolism
- Pharmaceutical Practices and Patient Outcomes
- Animal Nutrition and Physiology
- Erythropoietin and Anemia Treatment
- Analytical Chemistry and Chromatography
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Insect and Pesticide Research
- Diet and metabolism studies
- Phytochemicals and Antioxidant Activities
- Agricultural and Food Sciences
- Traditional and Medicinal Uses of Annonaceae
- Postharvest Quality and Shelf Life Management
- Glycosylation and Glycoproteins Research
- Protein Hydrolysis and Bioactive Peptides
- Pesticide Residue Analysis and Safety
- Neuroscience and Neuropharmacology Research
- Neutropenia and Cancer Infections
- Protease and Inhibitor Mechanisms
- Antioxidant Activity and Oxidative Stress
University of Toledo
2024
United States Department of the Army
2024
Integra (United States)
2019-2023
Connect
2023
Park University
2007-2022
South Carolina Oncology Associates
2001-2020
Geisinger Health System
2012-2019
United States Department of Veterans Affairs
1956-2018
Veterans Health Administration
2014-2018
Geisinger Medical Center
2004-2017
PURPOSE: To compare the efficacy and tolerability of tamoxifen with that letrozole, an oral aromatase inhibitor, as first-line therapy in postmenopausal women advanced breast cancer. PATIENTS AND METHODS: Nine hundred seven patients were randomly assigned letrozole 2.5 mg once daily (453 patients) or 20 (454 patients). Patients had estrogen receptor– and/or progesterone receptor–positive tumors, both receptors unknown. Recurrence during adjuvant antiestrogen within following 12 months prior...
The nature and content of lytic bodies the localization acid phosphatase (AcPase) activity were investigated in mammotrophic hormone-producing cells (MT) from rat anterior pituitary glands. MT examined lactating rats which secretion MTH(1) was high postlactating MTH suppressed by removing suckling young. animals contained abundant stacks rough-surfaced ER, a large Golgi complex with many forming secretory granules, few bodies, primarily multivesicular dense bodies. animals, sacrificed at...
Fecal occult-blood testing and sigmoidoscopy have been recommended for screening colorectal cancer, but the sensitivity of such combined detecting neoplasia is uncertain. At 13 Veterans Affairs medical centers, we performed colonoscopy to determine prevalence one-time with a fecal test plus sigmoidoscopy.
Multilocular brown adipose tissue in the rat is shown to increase both mass and respiratory rate, vitro, during cold acclimation. By vascular convection resulting heat directly applied thoracocervical regions of spinal cord, heart, other thoracic organs. The vasculature so arranged as exercise a fine order thermogenic control over fat temperature peripheral venous returns thorax, facilitated part by "reverse" type countercurrent exchange apparently not previously described.
Earlier indications that brown fat has a thermogenic role in rats exposed to cold suggested certain comparable functions hibernating marmots be investigated. From the results it appears arousal of animal by is induced sympathetically activated thermogenesis areas so located, relative vasculature, heat transferred thoracic structures and cervical spinal regions.
PURPOSE: To compare two doses of letrozole (0.5 mg and 2.5 every day) megestrol acetate (40 qid) as endocrine therapy in postmenopausal women with advanced breast cancer previously treated antiestrogens. PATIENTS AND METHODS: This double-blind, randomized, multicenter, multinational study enrolled 602 patients, all whom were included the primary analysis protocol. Patients had or metastatic evidence disease progression while receiving continuous adjuvant antiestrogen therapy, experienced...
The efficacy and safety of darbepoetin alpha (DA) for treating patients with active cancer anemia not receiving or planning to receive cytotoxic chemotherapy myelosuppressive radiotherapy was evaluated.Patients were enrolled onto a phase III, multicenter, randomized, placebo-controlled study administered placebo DA 6.75 microg/kg every 4 weeks (Q4W) up 16 2-year follow-up survival. Patients who completed treatment could the same as randomized Q4W an additional weeks. primary end point all...
(1984). A Comparative Outcome Study of Group Psychotherapy vs. Exercise Treatments for Depression. International Journal Mental Health: Vol. 13, Psychotherapies Depression, pp. 148-176.
Background. Liver biopsy remains critical for staging liver disease in hepatitis C virus (HCV)–infected persons, but is a bottleneck to evaluation, follow-up, and treatment of HCV. Our analysis sought validate APRI (aspartate aminotransferase [AST]–to-platelet ratio index) FIB-4, an index from serum fibrosis markers (alanine [ALT], AST, platelets plus patient age) stage disease. Methods. Biopsy results HCV patients the Chronic Hepatitis Cohort Study were mapped F0–F4 equivalent scale; FIB-4...
The number of deaths in hepatitis C virus (HCV)-infected persons recorded on US death certificates has been increasing, but actual rates and causes these individuals have not well elucidated.Disease-specific, liver-related, non-liver-related mortality data for HCV-infected patients an observational cohort study, the Chronic Hepatitis Cohort Study (CHeCS) at 4 healthcare systems, were compared with multiple cause (MCOD) 12 million 2006-2010. Premortem diagnoses, liver biopsies, FIB-4 scores...
Spilanthol (C14H23NO, 221.339 g/mol) is a bioactive compound that found in many different plants are used as traditional remedies throughout the world. It present Heliopsis longipes and several species genus Acmella, including A. oleracea L., also known paracress jambu. Its leaves flowers have sensory properties (pungency, tingling, numbing, mouth-watering) make it popular spice ingredient Brazilian dishes. can exert variety of biological pharmacological effects analgesic, neuroprotective,...
OBJECTIVE: Recent investigations of schizophrenia have targeted glutamatergic neurotransmission, since phencyclidine, an N-methyl-d-aspartate (NMDA) receptor antagonist, can induce schizophreniform psychosis. The authors previously reported alterations in thalamic NMDA subunit expression schizophrenia, consistent with the hypothesis that hypofunction may contribute to pathophysiology this illness. In study they generalized include other molecules glutamate synapse, specifically excitatory...
A purge and trap procedure was used with gas chromatography-mass spectrometry determination to analyze 70 foods for volatile organic compounds (VOCs). The results from analyses over a 5 year period (1996-2000) are reported. VOCs were found in at least one sample of all tested, although no single compound each the foods. total amount food item ranged 24 5328 ppb, creamed corn (canned) lowest cheddar cheese highest. Benzene except American vanilla ice cream. levels 1 190 highest level fully...
Plasma ketamine concentrations after diazepam and placebo pretreatment were examined in a double-blind, randomized, cross-over study. Eight healthy male subjects received either or 0.9% NaCl before the alternate combination 5 to 24 days later. Ten minutes dosing, diazepam, 0.3 mg/kg, equal volume was injected intravenously at rate not exceeding mg/min. Ketamine, 2.2 mg/kg iv, over 1 min. For clinically relevant period for anesthesia (1 30 min), diazepam-ketamine treatment resulted higher...