A5103480780- Systemic Lupus Erythematosus Research
- Anesthesia and Sedative Agents
- Rheumatoid Arthritis Research and Therapies
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacology and Obesity Treatment
- Pharmacogenetics and Drug Metabolism
- Epilepsy research and treatment
- Treatment of Major Depression
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Muscle metabolism and nutrition
- Pharmaceutical studies and practices
- Primary Care and Health Outcomes
- Microbial Inactivation Methods
- Systemic Sclerosis and Related Diseases
- Pharmacological Effects and Toxicity Studies
- Diabetes and associated disorders
- Antibiotic Resistance in Bacteria
- Receptor Mechanisms and Signaling
- Poisoning and overdose treatments
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Osteoarthritis Treatment and Mechanisms
- Inflammatory Bowel Disease
University of Pittsburgh
2024
Université de Montréal
2004-2005
McGill University
1998-2000
Montreal General Hospital
1993-1999
University of Iowa
1984
University of Michigan
1984
University of Illinois Urbana-Champaign
1984
University of Illinois Chicago
1984
Plasma ketamine concentrations after diazepam and placebo pretreatment were examined in a double-blind, randomized, cross-over study. Eight healthy male subjects received either or 0.9% NaCl before the alternate combination 5 to 24 days later. Ten minutes dosing, diazepam, 0.3 mg/kg, equal volume was injected intravenously at rate not exceeding mg/min. Ketamine, 2.2 mg/kg iv, over 1 min. For clinically relevant period for anesthesia (1 30 min), diazepam-ketamine treatment resulted higher...
Plasma levels of diphenylhydantoin and the urinary excretion its hydroxylated metabolite were studied in 6 normal adults following single intravenous doses 0.25 Gm. DPH‐sodium. The high initial plasma dropped rapidly to a mean value 6.3 µg per milliliter 20 minutes after dosing 5.2 one hour; half‐life later time periods was about 15 hours (range 11 29 hours). Urinary free conjugated HPPH 5 subjects, measured by new gas‐chromatography procedure, accounted for 76 cent dose 65 81 cent) over...
Pyrvinium pamoate, tablets and suspension, was administered as single 350-mg doses to 12 healthy male volunteers determine whether there had been any systemic absorption. Six subjects received 6 suspension on the first day; day 8, other dose form. Up 4 days after administration no evidence of drug in blood urine by spectroflorometric assay. Metabolic studies rats showed minute quantities liver plasma but not metabolites.
Abstract Approaches to reverse or limit regulatory T cell (Treg) insufficiency are of great interest for development immunotherapeutic treatments autoimmune patients, including type 1 diabetes. Treg is heavily implicated in the progression diabetes NOD mouse model and characterized by defects numbers, development, and/or function. Utilizing a Treg-centric screen, we show that intraislet Tregs have uniquely dysfunctional phenotype, hallmarked an almost complete lack neuropilin-1 (Nrp1),...
Objective. Health consumption and health status in SLE three countries with different funding structures were compared.
Objective. We have shown that SLE patients in Canada and the UK incurred 20% 13% lower health costs than those US, respectively, but did not experience worse outcomes as expressed by Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index. now compare change quality life these patients.
In a single-dose tolerance and pharmacokinetics study, enoxacin doses ranging from 200 to 1600 mg were administered orally 12 healthy normal volunteers. Plasma assays demonstrated rapid absorption of with first-order elimination half-life averaging 3.4–6.4 h. Renal clearance accounted for approximately 40% total body drug. second placebo-controlled 18 volunteers received in 400, 600 or 800 twice daily 14 days. concentrations pharmacokinetic parameters obtained after the first dose not...
Twenty subjects, in a double‐blind, controlled, rising dose study, were given ethosuximide either once daily or 3 times daily. Steady‐state plasma levels and urinary throughput proportional to equivalent whether the was as single divided dose. This finding adds validity consideration of regimen therapeutic possibility. The metabolic principles should be considered both patient management treatment overdosage.
The bioavailability of bevantolol was compared in 12 healthy volunteers given single doses the drug as HCl salt after an overnight fast, or 15 minutes before a standardized breakfast nonblind, randomized crossover design. Bevantolol rapidly absorbed all three treatment groups, with maximum concentrations (C max ) observed at 1.0, 0.9, and 1.8 hours for fasting, breakfast, respectively. Time to C significantly longer than fasting only when breakfast. Food ingestion did not affect , total...
The pharmacokinetics of pramiracetam, a new, investigational, cognition activator, were assessed in normal male volunteers as part clinical tolerance study. In double‐blind, randomized design, two groups six subjects each received alternating placebo and single 400, 800, 1,200, 1,600 mg oral doses pramiracetam after an overnight fast. Mean (± SD) peak plasma concentrations the four dose (2.71 ± 0.54, 5.40 1.34, 6.13 0.71, 8.98 0.71 μg/mL) attained between to three hours following drug...
Dobkin, P. L.; Da Costa, D.; Dritsa, M.; Fortin, R.; Senecal, J.; Goulet, J. Choquette, Esdaile, Beaulieu, A.; Cividino, Edworthy, S.; Barr, Ensworth, Gladman, Smith, Zummer, Rich, E.; Clarke, A. E. Author Information
A new sulfonamide, sulfacytine (1- ethyl-N-sulfanilylcytosine) has a short half-life, is highly soluble throughout the usual urinary pH range, and excretion almost entirely as free or microbiologically active form. Experimental mouse infections demonstrate 2- to 3- fold bacteriostatic activity compared sulfisoxazole. Plasma urine concentrations following three dose schedules of (2 grams/day, 1 gram/day, 0·5 grams/day) were determined over 7- day period by both colorimetric microbiologic...
Da Costa, D.; Clarke, A.E.; Dobkin, P.L.; Senecal, J.L.; Goulet, J.R.; Choquette, Grodzicky, T.; Fortin, P.R.; Danoff, D.S.; Esdaile, J.M. Author Information