A5106593630- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- PARP inhibition in cancer therapy
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Chemotherapy-induced cardiotoxicity and mitigation
- Heart Rate Variability and Autonomic Control
- Head and Neck Cancer Studies
- Human Health and Disease
- Transplantation: Methods and Outcomes
- Lung Cancer Research Studies
- Cardiac Arrhythmias and Treatments
- Cancer Genomics and Diagnostics
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Atomic and Subatomic Physics Research
- Cancer-related gene regulation
- Mechanical Circulatory Support Devices
Xiangya Hospital Central South University
2025
Central South University
2025
Sichuan University
2010-2024
West China Hospital of Sichuan University
2010-2024
Sichuan Cancer Hospital
2024
Kunming Medical University
2020
Fourth Affiliated Hospital of Harbin Medical University
2018
Harbin Medical University
2018
RPS6KA1 express disorder is associated with many cancers, but the role in head and neck squamous cell carcinoma (HNSCC) specific mechanism still unclear. We used bioinformatics analysis to explore of Ribosomal Protein S6 Kinase A1(RPS6KA1) HNSCC which were predicted regulate certain pathway immune microenvironment increase risk HNSCC. Multiple tools based on EBI, GEO, TCGA databases clinical samples analyze expression RPS6K1 Western blot (WB) PCR results confirmed upregulation tissues. Flow...
Head and neck cancer is the sixth most common malignancy around world, 90% of cases are squamous cell carcinomas. In this study, we performed a systematic investigation immunogenomic landscape to identify prognostic biomarkers for head carcinoma (HNSCC). We analyzed expression profiles immune-related genes (IRGs) clinical characteristics by interrogating RNA-seq data from 527 HNSCC patients in genome atlas (TCGA) dataset, including 41 HPV+ 486 HPV- samples. found that differentially...
Abstract Background Cancer therapy‐related cardiovascular toxicity (CTR‐CVT) is a major contributor to poor prognosis in breast cancer (BC) patients undergoing chemotherapy. Left ventricular global longitudinal strain (LV GLS) has predictive value for CTR‐CVT, while few researchers take into account late‐onset CTR‐CVT. This study sought provide guide the prediction of CTR‐CVT primary BC over 2 years follow‐up via and contrast‐enhanced echocardiography. Methods Anthracycline anthracycline +...
Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or microRNAs (miRNAs) associated lymph node metastasis SCLC.The DEGs between groups were identified, GO functional KEGG pathway enrichment analyses for these implemented. Subsequently, protein-protein interaction network subnetwork module constructed. Then regulatory networks based on miRNAs,...
Abstract Background This prospective real‐world study aimed to assess the efficacy and safety of eribulin in clinical practice against advanced breast cancer (ABC) China. Patients Methods In this study, eligible patients with inoperable locally or metastatic who had experienced prior neo−/adjuvant failed palliative treatment anthracycline/taxanes were included. Eribulin (1.4 mg/m 2 ) was infused intravenously on Day 1 8 every 3 weeks until disease progression intolerable toxicity occurred....
1087 Background: Breast cancer is the most common among women, with up to 37% of patients (pts) harboring germline BRCA1/2 mutations (g BRCA1/2m) that appear be sensitive poly (ADP-ribose) polymerase proteins 1 and 2 (PARP1/2) inhibition. Pamiparib an orally administered selective PARP1/2 inhibitor has potential cross blood-brain barrier. This study evaluated efficacy safety pamiparib in pts locally advanced/metastatic human epidermal growth factor receptor 2-negative (HER2-) breast cancer,...
Currently, lung cancer is a leading cause of global mortality, often necessitating minimally invasive interventions. Microwave ablation (MWA) extensively utilized for both primary and secondary tumors. Although numerous clinical guidelines standards MWA have been established, the evaluation surgery remains challenging requires long-term patient follow-up confirmation. In this paper, we propose method termed respiratory subtraction to evaluate tumor therapy performance based on pre-...
e13126 Background: Eribulin is a novel synthetic analog of halichondrin B that acts as microtubule inhibitor and inhibits the G2-M growth phase. was approved for metastatic breast cancer (MBC) based on landmark phase 3 EMBRACE trial (Cortes et al, Lancet 2011; NCT00388726); however, only small number Asian patients were included in trial. Therefore, this real-world study, we retrospectively assessed clinical outcomes Chinese with MBC who received eribulin. Methods: Adult eribulin several...