A5015075416- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Magnetism in coordination complexes
- Synthesis and Biological Evaluation
- Organic and Molecular Conductors Research
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Metal complexes synthesis and properties
- Peptidase Inhibition and Analysis
- Cardiovascular Health and Risk Factors
- Viral Infections and Immunology Research
- Synthesis of β-Lactam Compounds
- COVID-19 Clinical Research Studies
- Cell death mechanisms and regulation
- Vasculitis and related conditions
- Cerebrovascular and Carotid Artery Diseases
- Sodium Intake and Health
- PARP inhibition in cancer therapy
- Traditional Chinese Medicine Analysis
Zhengzhou University
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
Henan Provincial People's Hospital
2022-2023
Henan University
2023
Southern Medical University
2012-2022
Zhujiang Hospital
2019-2022
Center for Global Health
2021
Tianjin University
2015
Novel small molecule compounds based on various scaffolds including chalcone, flavonoid, and resorcinol dibenzyl ether were designed tested for their inhibitory activity against the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) pathway. Among them, compound NP19 inhibited human PD-1/PD-L1 interaction with IC50 values of 12.5 nM in homogeneous time-resolved fluorescence (HTRF) binding assays. In addition, dose-dependently elevated IFN-γ production a coculture model...
<h3>Objective</h3> To construct a polygenic risk score (PRS) for stroke and evaluate its utility in stratification primary prevention stroke. <h3>Methods</h3> Using meta-analytic approach large genome-wide association results stroke-related traits East Asians, we generated combined PRS (metaPRS) by incorporating 534 genetic variants training set of 2,872 patients with 2,494 controls. We then validated incident using Cox regression models Chinese population-based prospective cohorts...
A series of programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors based on the resorcinol diphenyl ether scaffold were discovered by incorporating hydrophilic moieties into side chain and converting corresponding hydrochloride salt. Among these compounds,
Abstract SARS‐CoV‐2 caused the emerging epidemic of coronavirus disease in 2019 (COVID‐19). To date, there are more than 82.9 million confirmed cases worldwide, is no clinically effective drug against infection. The conserved properties membrane fusion domain spike (S) protein across make it a promising target to develop pan‐CoV therapeutics. Herein, two approved drugs, Itraconazole (ITZ) and Estradiol benzoate (EB), found inhibit viral entry by targeting six‐helix (6‐HB) core S protein....
Mesenchymal stem cells (MSCs) have potential role in organ regeneration therapy. Previous work indicating that MSCs confer protection against liver disease. Here, we aimed to determine the application of human placenta-derived extracellular vesicles (hPMSCs-EVs) via experimental hepatectomy. hPMSCs-EVs were administered intravenously 24 h before 70% partial hepatectomy, specific composition was identified by sequencing and validated quantitative polymerase chain reaction, including...
Two lanthanide coordination polymers (CPs) {[Er(Hmtbd)(H2mtbd)(H2O)3]·2H2O}n (1) and [Yb(Hmtbd)(H2mtbd)(H2O)3]n (2) carrying an N-heterocyclic carboxylate ligand 5-(3-methylformate-1H-1,2,4-triazole-1-methyl)benzen-1,3-dicarboxylate (H3mtbd) were prepared under solvothermal conditions. The single-crystal X-ray diffraction data demonstrate that 1 2 are isostructural display 1D chain structure. Alternating current (AC) impedance measurements illustrate the highest proton conductivities of can...
Purpose: In information economy era, innovation is the key to improve competitiveness of enterprises. The traditional way enterprise outdated and supply chain collaborative has becoming popular. This paper aims analyses mechanism knowledge sharing between enterprises in innovation. Design/methodology/approach: analyzes members' willingness share by using game theory. And result two companies analyzed evolutionary game. Findings: We broke process into mining transferring. got best strategy...
Background Circular RNAs (circRNAs) play a pivotal regulatory role in variety of tumors.Nevertheless, the detailed function circ_0000003 non-small cell lung cancer (NSCLC) and its mechanism remain elusive.Methods RT-PCR was carried out to detect expressions circ_0000003, miR-338-3p insulin receptor substrate 2 (IRS2)in NSCLC tissues. Besides, western blot done monitor IRS2 expression cells. The correlation between clinicopathologic characteristics patients analyzed as well.CCK8 BrdUassays...
Both genetic factors and environmental air pollution contribute to the risk of stroke. However, it is unknown whether association between stroke influenced by susceptibilities its factors. This prospective cohort study included 40 827 Chinese adults without history. Satellite-based monthly fine particulate matter (PM2.5) estimation at 1-km resolution was used for exposure assessment. Based on 534 identified variants from genome-wide studies in East Asians, we constructed 6 polygenic scores...
In this work, we design and synthesize one organic molecule solid-state material three metal–organic frameworks, (H3tcpb·H2O)n (H3tcpb-H2O), [Mn2(Htcpb)(μ3-SO4)(H2O)2]·H2O}n (1), {[Co(Htcpb)(H2O)3]·0.5CH3CN·H2O}n (2), {[Ni(Htcpb)(H2O)3]·H2O}n (3), based on 2-(6-phenyl-[2,3′-bipyridin]-4-yl)benzene-1,3,5-tricarboxylic acid (H3tcpb) to study their proton transport pathways conducting mechanisms. The electrochemical experimental results demonstrated that the finest conductivity (σ) value of 1...
Background Association between tea consumption and incident hypertension remains uncertain. This study conducted to examine the health effects of on blood pressure progression incidence. Methods A population-based cohort 38,913 Chinese participants without at baseline were included in current study. Information was collected through standardized questionnaires. Associations with analyzed using logistic regression models Cox proportional hazards models, respectively. Results During a median...
Transplant renal artery stenosis (TRAS) is a vascular complication after kidney transplantation associated with poor outcomes. This study aimed to analyze the efficacy and safety of low-dose aspirin for preventing TRAS.After transplantation, patients were enrolled from January 2018 December 2020 in Henan Provincial People's Hospital. A total 351 recipients randomized an group intake addition standard treatment ( n = 178), or control only 173). The was initially diagnosed as TRAS (id-TRAS) by...
Five coordination compounds [Cu 2 (impc) (µ ‐OH)Cl] n ( 1 ), ‐OH)Br] [Co(impc) (H O) ] 3 [Co 4 (SO ) O)] and {[Co(impc)(H · H O} 5 based on asymmetric 5‐(1 ‐imidazole‐1‐yl)‐3‐pyridinecarboxylic acid (Himpc) have been hydrothermally synthesized structurally characterized. are isostructural consist of binuclear Cu II units display two‐dimensional (2D) framework, where present a new {(4.6 )(4 .6 .8 .10)(4)} topology. features 1D chain structure. Polymer , which also displays Schläfli symbol {(4...
Objective To examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations. Methods Fine and Grey’s models were used calculate HRs their corresponding 95% CIs, as well lifetime CVH metrics across Polygenic Risk Score (PRS) categories. Results We included 39 755 individuals aged 30–75 years Chinese prospective cohorts. 1275 CAD cases recorded over a mean follow-up 12.9 years. Compared with unfavourable...
Six ferrocenyl monocarboxylate Mn(<sc>ii</sc>), Ni(<sc>ii</sc>) and Co(<sc>ii</sc>) complexes with different types of magnetic coupling bridges were synthesized successfully. <bold>1–6</bold> display intriguing structure diversity properties.
Hepatocellular carcinoma (HCC) is one of the commonest lethal malignancies worldwide, and often diagnosed at an advanced stage, without any curative therapy. Immune checkpoint blockers targeting programmed death receptor 1 (PD-1) have shown impressive antitumor activity in patients with advanced-stage HCC, while response rate only 30%. Inducible PD-L1 overexpression may result a lack to cancer immunotherapy, which attributed mechanism adaptive immune resistance. Our study investigated that...
Four similar 1D metal‐organic polymers [Cd(impc) 2 (H O) ] n ( 1 ), [Co(impc) [Mn(impc) 3 and {[Cu(impc) · [jy2H O} 4 ) based on an asymmetric 5‐(1H‐imidazole‐l‐yl)‐3‐pyridinecarboxylic acid (Himpc) were prepared hydrothermally structurally characterized. According to the frontier molecular orbital (FMOs) calculations, photoluminescence of should be assigned as n→π* transition. The antibacterial properties – studied. exhibited good activities towards B. subtilis S. aureus with smallest MIC...
The global spread of the novel coronavirus SARS-CoV-2 urgently requires discovery effective therapeutics for treatment COVID-19. spike (S) protein plays a key role in receptor recognition, virus-cell membrane fusion and virus entry. Our previous studies have reported that 3-hydroxyphthalic anhydride-modified chicken ovalbumin (HP-OVA) serves as viral entry inhibitor to prevent several kinds infection. Here, our results reveal HP-OVA can effectively inhibit replication S protein-mediated...