A5054854355- Cancer Immunotherapy and Biomarkers
- Synthesis and Biological Evaluation
- Synthesis of β-Lactam Compounds
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Phytochemistry and biological activity of medicinal plants
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Synthesis and biological activity
- Melanoma and MAPK Pathways
- Fungal Plant Pathogen Control
- CAR-T cell therapy research
- Genomics, phytochemicals, and oxidative stress
Southern Medical University
2020
Xinjiang Medical University
2013-2017
A series of programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors based on the resorcinol diphenyl ether scaffold were discovered by incorporating hydrophilic moieties into side chain and converting corresponding hydrochloride salt. Among these compounds,
Objective To investigate the in vitro anticancer activity of glycyrrhetinic acid-fluorouracil compound (GA-Fu).Methods The human Bel-7402 hepatoma cell lines were treated with GA-Fu compound,the proliferation capability was determined by methyl thiazolyl diphenyl-tetrazolium bromide (MTT) method.Normal chang liver cells used to test its cytotoxicity.The data compared those 5-fluorouracil (5-Fu) drug.Results Compound showed less cytotoxicity normal (lower than 5-Fu,P ＜ 0.05).However,a...