A5101877925- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Cardiac electrophysiology and arrhythmias
- Biomarkers in Disease Mechanisms
- Cardiac Fibrosis and Remodeling
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Connective Tissue Growth Factor Research
- Protein Kinase Regulation and GTPase Signaling
- Wnt/β-catenin signaling in development and cancer
- Ion channel regulation and function
- Galectins and Cancer Biology
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- 14-3-3 protein interactions
- Cardiovascular Function and Risk Factors
- Ion Transport and Channel Regulation
- Nuclear Receptors and Signaling
- ATP Synthase and ATPases Research
- Histone Deacetylase Inhibitors Research
- Cholinesterase and Neurodegenerative Diseases
- Protein Tyrosine Phosphatases
- Redox biology and oxidative stress
- Heat shock proteins research
Southwest Medical University
2024
University of Washington
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
California Institute for Regenerative Medicine
2020
University of California, Los Angeles
2014-2019
Baotou Medical College
2014
University of Rochester
2008-2013
Montclair State University
2012
University of Manchester
2012
Howard Hughes Medical Institute
2012
Ferroptosis, a recently unveiled iron-dependent form of cellular demise, has emerged as pivotal process contributing to the pathology Alzheimer's Disease (AD). Glutathione Peroxidase 4 (GPX4), vital defense mechanism countering ferroptosis by nullifying lipid peroxides and maintaining redox equilibrium, garnered significant attention in AD. Thus, identifying inhibitors target GPX4 activation may help mitigate neuronal damage impede AD progression.
Calcium (Ca2+) is a key regulator of energy metabolism. Impaired Ca2+ homeostasis damages mitochondria, causing cardiomyocyte death, pathological hypertrophy, and heart failure. This study investigates the regulation role mitochondrial uniporter (MCU) in chronic stress-induced cardiac remodeling.MCU knockout or transgenic mice were infused with isoproterenol (ISO; 10 mg/kg per day, 4 weeks). Cardiac hypertrophy remodeling evaluated by echocardiography histology. Primary cultured rodent adult...
Objective— Cyclophilin A (CyPA, encoded by Ppia ) is a proinflammatory protein secreted in response to oxidative stress mice and humans. We recently demonstrated that CyPA increased angiotensin II (Ang II)–induced reactive oxygen species (ROS) production the aortas of apolipoprotein E ( Apoe −/− mice. In this study, we sought evaluate role Ang II–induced cardiac hypertrophy. Methods Results— Cardiac hypertrophy was not significantly different between +/+ infused with (1000 ng/min per kg for...
Osteoclasts are bone-resorbing cells, but they also secrete and respond to cytokines. Here, we test the hypothesis that osteoclasts lymphatic growth factor, VEGF-C, increase their resorptive activity. osteoclast precursors were generated by culturing splenocytes with macrophage colony-stimulating factor RANKL from wild-type, NF-kappaBp50(-/-)/p52(-/-), Src(-/-) mice. Expression of VEGFs was measured real time reverse transcription-PCR, Western blotting, immunostaining. The effect VEGF-C...
Cardiomyocyte apoptosis is one of the key events in development and progression heart failure, a crucial role for ICER (inducible cAMP early repressor) this process has been previously reported. ERK5 known to inhibit cardiac after myocardial infarction (MI), especially hyperglycemic states, via association with CHIP ubiquitin (Ub) ligase subsequent upregulation activity, which induces ubiquitination protein degradation. The regulatory mechanism governing ERK5/CHIP interaction unknown.
Growing evidence indicates a critical role of ubiquitin-proteosome system in apoptosis regulation. A cardioprotective effect ubiquitin (Ub) ligase the C terminus Hsc70-interacting protein (CHIP) on myocytes has been reported. In current study, we found that insulin growth factor-1 (IGF-1) was mediated by ERK5-CHIP signal module via inducible cAMP early repressor (ICER) destabilization. vitro runoff assay and Ub showed ICER as substrate CHIP ligase. Both disruption binding with inhibitory...
The role of Mesenchymal-endothelial transition (MEndoT) in cardiac hypertrophy is unclear. To determine the difference between MEndoT-derived and coronary endothelial cells essential for understanding revascularizing strategy repair. Using lineage tracing we demonstrated that exhibit highly heterogeneous which were characterized with expression markers such as vascular cadherin(VECAD) occludin but low Tek receptor tyrosine kinase(Tek), isolectin B4, nitric oxide synthase(eNOS), von...
This study was aimed to investigate the mRNA and protein expression of CTGF, CYR61, VEGF-C VEGFR-2 in bone marrow patients with leukemia, analyze role clinical significance these 4 factors genesis development infiltration metastasis leukemic cells. A total 100 cases newly diagnosed 26 acute leukemia complete remission 30 controls were enrolled this study. The mononuclear cells collected, levels VEGF-C, detected by real time PCR Western blot, respectively. results showed that above mentioned...
Growing evidence indicates a critical role of ubiquitin-proteosome system in apoptosis regulation. A cardioprotective effect ubiquitin (Ub) ligase the C terminus Hsc70-interacting protein (CHIP) on myocytes has been reported. In current study, we found that insulin growth factor-1 (IGF-1) was mediated by ERK5-CHIP signal module via inducible cAMP early repressor (ICER) destabilization. vitro runoff assay and Ub showed ICER as substrate CHIP ligase. Both disruption binding with inhibitory...
Rationale: Cardiac dysfunction is accelerated in DM patients after MI. Previously, we reported the critical role of ERK5 and CHIP association on Ub E3 ligase activity, which inhibits inducible cAMP early repressor (ICER)-mediated apoptosis left ventricle (LV) MI (DM + MI). Yet regulatory mechanism ERK5-CHIP has not been established. Objective: Since found that p90RSK activation was increased heart, investigated whether may inhibit ERK5-mediated activation, subsequent ICER induction...
Background - Cyclophilin A (CyPA) is a chaperone protein secreted from vascular smooth muscle cells (VSMC) in response to reactive oxygen species (ROS). We have recently demonstrated that extracellular CyPA stimulates at least 3 signaling pathways (ERK1/2, Akt and JAK) mediates numerous cellular effects of ROS. Angiotensin II (Ang II) induces ROS through NADPH oxidases activates matrix metalloproteinase (MMP) VSMC. MMPs been mediate cardiac hypertrophy remodeling. hypothesized VSMC-derived...
Abstract Background: There is very little literature on Pulmonary hypertension associated with myocardial amyloid degeneration. At present, only 10 cases pulmonary cased by protein deposits in the blood vessels have been reported Eder et al. We a case that patient was artery combined change. It’s aim to claims most likely caused fibrin deposition vessels. Case presentation: report of 65-year-old male AL and ATTR type amyloidosis who developed right heart failure because severe hypertension....