A5100331093- Circular RNAs in diseases
- MicroRNA in disease regulation
- Axon Guidance and Neuronal Signaling
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Congenital heart defects research
- Advanced MRI Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Ion channel regulation and function
- Cardiovascular Disease and Adiposity
- Cardiomyopathy and Myosin Studies
- Phosphodiesterase function and regulation
- Neuropeptides and Animal Physiology
- Traditional Chinese Medicine Analysis
- Hippo pathway signaling and YAP/TAZ
- Williams Syndrome Research
- Apelin-related biomedical research
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Lipid metabolism and disorders
- Traditional Chinese Medicine Studies
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
Hangzhou Children's Hospital
2025
Ping An (China)
2024
First Affiliated Hospital Zhejiang University
2024
Royal Veterinary College
2024
Blood Center of Zhejiang Province
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Soochow University
2022-2023
First Affiliated Hospital of Soochow University
2022-2023
Minzu University of China
2023
Guangdong Laboratory Animals Monitoring Institute
2020-2023
Noncoding RNAs such as circular (circRNAs) are abundant in the human body and influence occurrence development of various diseases. Non-small cell lung cancer (NSCLC) is one most common malignant cancers. Information on functions mechanism circRNAs limited; thus, topic needs more exploration. The purpose this study was to identify aberrantly expressed cancer, unravel their roles NSCLC progression, provide new targets for diagnosis therapy.High-throughput sequencing used analyze differential...
Background: Cyanotic congenital heart disease (CCHD) is a complex pathophysiological condition involving systemic chronic hypoxia (CH). Some patients with CCHD are unoperated for various reasons and remain chronically hypoxic throughout their lives, which heightens the risk of failure as they age. Hypoxia activates cellular metabolic adaptation to balance energy demands by accumulating hypoxia-inducible factor 1-α (HIF-1α). This study aims determine effect CH on cardiac metabolism function...
Rationale: Fetal intestinal volvulus, a rare and severe disorder, poses significant diagnostic challenges prenatally can lead to intrauterine death or adverse neonatal outcomes if untreated in timely manner. This study reports case of fetal volvulus confirmed postoperatively, providing insights into its clinical manifestations, methods, treatment outcomes, thereby enhancing understanding this condition. Patient concerns: A Chinese gravida 2, para 1 female presented at 32 weeks 5 days...
β-Arrestin plays a key role in regulating β2-adrenoreceptor signaling by interdicting activation of adenylyl cyclase and selectively sequestering cAMP phosphodiesterase-4D5 (PDE4D5) for delivery an active degrading system to the site synthesis. Here we show that β-agonist, isoprenaline, triggers rapid transient ubiquitination PDE4D5 primary cardiomyocytes, mouse embryo fibroblasts, HEK293B2 cells constitutively expressing β2-adrenoceptors. Reconstitution analyses β-arrestin1/2 double...
Previous studies have suggested the role of CD4+Foxp3+ regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, associated mechanisms Tregs not been fully elucidated. Semaphorin 4A (Sema4A) is essential for maintaining capacity tumors. However, whether Sema4A can alleviate through has yet demonstrated. Here, we investigated effect and mechanism on development injury. Administration recombinant human Sema4A-Fc...
Heart failure is induced by multiple pathological mechanisms, and current therapies are ineffective against heart with preserved ejection fraction (HFpEF). As there limited animal models of HFpEF, its underlying mechanisms have not yet been elucidated. Here, we employed the descending aortic constriction (DAC) technique to induce chronic pressure overload in left ventricles Tibetan minipigs for 12 weeks. Cardiac function, cellular changes, fibrotic signaling activation, gene expression...
The murine transverse aortic constriction (TAC) model is frequently used to investigate molecular mechanisms underlying heart failure. However, limited data available regarding the expression of mRNAs and circRNAs in failure progression induced by pressure overload.Transverse was induce overload for 2, 4, 8 weeks mice. Echocardiographic measurements B-mode M-mode, as well blood flow Doppler were collected mice without (sham) with (2W-, 4W-, 8W-post-TAC) load. Hearts excised morphology,...
Abstract Antarctic krill oil is functional and has a complex phospholipids composition that poses difficulties in elucidating its effect mechanism on ulcerative colitis (UC). The of UC action was studied by bioinformatics, the therapeutic (APL) dextran sulfate sodium (DSS)-induced mice verified. GO enrichment analysis uncovered an these genes regulation cell–cell adhesion, membrane region, signaling receptor activator activity, cytokine activity. Meanwhile, KEGG results revealed were...
Background: Pressure overload can result in dilated cardiomyopathy. The beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on heart disorders have been widely recognized. However, the molecular mechanisms underlying their protective against cardiomyopathy remain unclear. Methods: mice induced by 8 weeks transverse aortic constriction was used to induce A transgenic fat-1 mouse model carrying acid desaturase gene from Caenorhabditis elegans evaluate mechanism PUFAs this...
Background The axon guidance cue Slit2 recently has been found to regulate calcium homeostasis and molecular signaling in various stress events different organs. However, whether plays a role cardiac ischemia-reperfusion (IR) injury not reported. Here, we aimed investigate the of underlying mechanisms IR injury. Methods Langendorff-perfused isolated hearts from Slit2-overexpressing (Slit2-Tg) mice their background strain C57BL/6J were subjected 20 min global ischemia followed by 40...
Research on liver aging has become prominent and attracted considerable interest in uncovering the mechanism therapeutic targets of to expand lifespan. In addition, multi-omics studies are widely used perform further mechanistic investigations aging. this review, we illustrate changes that occur with liver, present current models aging, emphasize existing We integrated data enrolled reanalyzed them identify key pathways The results indicated C-X-C motif chemokine ligand 9 (Cxcl9) was a...
Background: While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are available regarding how these affect membrane receptors and their downstream signaling following IR injury. We aimed to identify potential activated by PUFAs in hearts understand regulatory mechanisms receptors. Methods: used fat-1 mice, which naturally elevated levels PUFAs, C57BL/6J mice as a control group create...
Normal pressure hydrocephalus (NPH) is a brain disorder caused by disruption of the flow cerebrospinal fluid (CSF). The dementia-like symptoms NPH are often mistakenly attributed to Alzheimer's disease. However, if correctly diagnosed, patients can potentially be treated and their reversed through surgery. Observing dilated ventricles magnetic resonance imaging (MRI) one element in diagnosing NPH. Diagnostic accuracy therefore benefits from accurate, automatic parcellation ventricular system...
Huntington's disease (HD) is an autosomal dominant neurodegenerative caused by mutant huntingtin (Htt) with expanded polyglutamine tract. It has been reported that Htt regulates autophagy. However, it remains unclear whether affects chaperone-mediated autophagy (CMA). Our study aimed to investigate the effect of on CMA activity in cultured HEK293T cells. A cell model HD was produced transient transfection wild-type (20Q) or (120Q) plasmids. The two components, lysosomal-associated membrane...
Abstract Gallstone is a common disease of biliary system at present. At present, our research on its pathogenesis still single analysis stage. In this study, we collected peripheral serum samples from patients with gallstones and non-biliary diseases, obtained the difference metabolites in blood both sides through omics technology, established clinical risk prediction model for based information patients. The weighted gene co-expression network was applied to find metabolite set high...
Abstract Osteoarthritis (OA) is characterised by the deterioration of cartilage in joints and pain. We hypothesise that semaphorin‐3A (sema‐3A), a chemorepellent for sensory nerves, plays role joint degradation used mechanical loading (MJL) model OA to investigate sema‐3A expression examine its association with development also analyse effect on chondrocyte differentiation using ATDC5 cell line. demonstrate present most tissues healthy increases highly innervated tissues, such as cruciate...
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