A5101463554- Immune Cell Function and Interaction
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Ocular Surface and Contact Lens
- Neuropeptides and Animal Physiology
- Toxoplasma gondii Research Studies
- Drug Transport and Resistance Mechanisms
- Vagus Nerve Stimulation Research
- Gut microbiota and health
- Herpesvirus Infections and Treatments
- Mast cells and histamine
- Macrophage Migration Inhibitory Factor
- Circadian rhythm and melatonin
- Galectins and Cancer Biology
- Rabies epidemiology and control
- Fatty Acid Research and Health
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Receptor Mechanisms and Signaling
- Insect symbiosis and bacterial influences
- Cardiac Fibrosis and Remodeling
- Pediatric Pain Management Techniques
- Carbohydrate Chemistry and Synthesis
- Inflammasome and immune disorders
- Microbial Metabolic Engineering and Bioproduction
Jinan University
2015-2024
First Affiliated Hospital of Jinan University
2024
Shenyang Pharmaceutical University
2024
Air Force Medical University
2023
University of Wisconsin–Madison
2023
Salk Institute for Biological Studies
2022
Monash University
2021
The University of Melbourne
2020
Baker Heart and Diabetes Institute
2020
Affiliated Zhongshan Hospital of Dalian University
2019
Objectives A population of atypical memory B cells (AtMs) are greatly expanded in patients with active lupus, but their generation and pathophysiological roles poorly defined. The aim this study was to comprehensively characterise lupus AtMs a purpose identify therapeutic clues target cell lupus. Methods Peripheral subsets were measured by flow cytometry. Sorting-purified subject RNA sequencing functional studies. Plasma cytokines secreted immunoglobulins detected Luminex or ELISA. In situ...
The pleiotropic actions of the Farnesoid X Receptor (FXR) are required for gut health, and reciprocally, reduced intestinal FXR signaling is seen in inflammatory bowel diseases (IBDs). Here, we show that activation selectively intestine protective inflammation-driven models IBD. Prophylactic restored homeostatic levels pro-inflammatory cytokines, most notably IL17. Importantly, these changes were attributed to regulation innate lymphoid cells (ILCs), with both increases ILCs, ILC3s...
The lacrimal gland is responsible for maintaining the health of ocular surface through production tears. However, our understanding immune system within currently limited. Therefore, in this study, we utilized single-cell RNA sequencing and bioinformatic analysis to identify analyze cells molecules present glands normal mice. A total 34,891 were obtained from mice classified into 18 distinct cell clusters using Seurat clustering. Within these populations, 26 different subpopulations...
Abstract The development of the cornea, a highly specialized transparent tissue located at anterior eye, is coordinated by variety molecules and cells. Here, we report that mast cells (MCs), recently found to be involved in morphogenesis, played potentially important role corneal mice. We show two different waves MC migration occurred during development. In first wave, MCs migrated stroma became distributed throughout cornea. This wave embryonic day 12.5, with disappearing from cornea time...
Allergic conjunctivitis (AC), an allergen-induced ocular inflammatory disease, primarily involves mast cells (MCs) and eosinophils. The role of neuroimmune mechanisms in AC, however, remains to be elucidated. We investigated the effects transient receptor potential vanilloid 1 (TRPV1)-positive sensory nerve ablation (using resiniferatoxin) TRPV1 blockade Acetamide, N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl] (AMG-517)) on ovalbumin-induced conjunctival allergic...
Antibiotics are extremely useful, but they can cause adverse impacts on host bodies. We found that antibiotic treatment altered the composition of gut microbiota and gene expression profile in corneal tissues postnatal mice decreased size thickness, angiogenesis limbal blood vessels, neurogenesis nerve fibers. The reconstitution with fecal transplants antibiotic-treated largely reversed these impairments development. Furthermore, C–C chemokine receptor type 2 negative (CCR2−) macrophages...
The pathogen Staphylococcus aureus can readily develop antibiotic resistance and evade the human immune system, which is associated with reduced levels of neutrophil recruitment. Here, we present a class antibacterial peptides potential to act both as antibiotics chemoattractants. compounds, term 'antibiotic-chemoattractants', consist formylated peptide (known chemoattractant for recruitment) that covalently linked vancomycin bind bacterial cell wall). We use combination in vitro assays,...
The peptide trefoil factor family 3 (TFF3) is a major constituent of the intestinal mucus, playing an important role in repair epithelial surfaces. To further understand TFF3 protection epithelium, we tested influence murine Toxoplasma gondii-induced ileitis model. Surprisingly, TFF3(KO) mice showed reduced immune response ileum when compared to wild-type animals. Interleukin-12 and interferon-γ expression levels as well number CD4(+) lymphocytes were infected mice. These effects line with...
Abstract Exposure to tobacco smoke is a major public health concern that can also affect ophthalmic health. Based on previous work demonstrating the important role of sympathetic nervous system (SNS) in corneal wound repair, we postulated acute exposure (ATSE) may act through SNS impairment repair. Here find ATSE rapidly increases markers inflammatory response normal limbi. After an abrasion injury, exaggerates inflammation, impairs and enhances expression nuclear factor-κB (NF-κB) molecules...
The spleen plays an important role in coordinating both adaptive and innate immune responses. Here, the transcriptional response to T. gondii infection murine was characterized concerning inflammasome sensors (two different models: seven days after oral or four weeks intraperitoneal infection). Additionally, Tff1KO Tff3KO mice were investigated because TFF genes are often upregulated during inflammation. expression of pattern-recognition receptors Nlrp3, Nlrp12, Nlrp1a significantly...
The trefoil factor family (TFF) peptide TFF1 is a typical secretory product of the gastric mucosa and very low level expression occurs in nearly all regions murine brain. possesses lectin activity binding to plethora transmembrane glycoproteins could explain diverse biological effects (e.g., anti-apoptotic effect). It was aim test whether TFF changed during neuroinflammation.Expression profiling performed using semi-quantitative RT-PCR analyses two models neuroinflammation, i.e. Toxoplasma...
Background and Objectives: Appropriate inflammatory response is necessary for cardiac repairing after acute myocardial infarction (MI).Three-Bromo-4,5-dihydroxybenzaldehyde (BDB) a potent antioxidant natural bromophenol compound derived from red algae.Although BDB has been shown to have an anti-inflammatory effect, it remains unclear whether affects remolding MI.The aim of this study was investigate the potential role on function recovery MI in mice.Methods: Mice were intraperitoneally...
This study aims to investigate the potential involvement of spleen-derived monocytes in repair process following corneal epithelial abrasion.A abrasion model was established male C57BL/6J mice, and dynamic changes monocyte subpopulations injured cornea were analyzed using flow cytometry. The effects Ly6Chi depletion local adoptive transfer purified on wound closure neutrophil recruitment observed. effect sympathetic nerves also investigated multiple methods. emigration fluorescence-labeled...
Abstract Bile acids (BAs) affect the intestinal environment by ensuring barrier integrity, regulating epithelium turnover, maintaining microbiota balance, and modulating immune system. As a master regulator of BAs homeostasis innate immunity, Farnesoid X Receptor (FXR), is severely compromised in inflammatory bowel disease (IBD) colitis-associated colorectal carcinoma (CAC) patients. At front line, gut macrophages react to metabolites that breach epithelium. We aim study role BAs-FXR axis...