A5100601358- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Circadian rhythm and melatonin
- Bacteriophages and microbial interactions
- Ocular Surface and Contact Lens
- Gut microbiota and health
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental and Agricultural Sciences
- Antimicrobial Resistance in Staphylococcus
- Antimicrobial agents and applications
- Tribology and Wear Analysis
- Energy, Environment, Economic Growth
- Monoclonal and Polyclonal Antibodies Research
- Bioactive natural compounds
- Mitochondrial Function and Pathology
- Escherichia coli research studies
- Seed Germination and Physiology
- Dietary Effects on Health
- Bone Metabolism and Diseases
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Advanced Glycation End Products research
- Toxic Organic Pollutants Impact
- Vagus Nerve Stimulation Research
Chinese Academy of Agricultural Sciences
2021-2025
Longyan University
2025
First Affiliated Hospital of Jinan University
2022-2025
Xihua University
2025
Northwest University
2025
Xinjiang Academy of Agricultural Sciences
2007-2025
Jinan University
2008-2024
Guangdong University of Technology
2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2024
Guangdong Academy of Sciences
2022
The coordinated development of digitalization and greening is essential for economic transformation upgrading, especially given the pressing global carbon emission challenges. China’s commitment to achieving “dual carbon” goals highlights need sustainable solutions, particularly in manufacturing sector, which a significant source energy consumption emissions; emissions account more than 30%. Integrating advanced digital technologies with critical reducing growth. According research results,...
The frequency of antimicrobial resistance has increased globally due to misuse and overuse antibiotics, multi-drug resistant (MDR) bacteria are now recognized as a major cause hospital-acquired infections (HAI). Our aim was investigate the prevalence, distribution, susceptibility rates MDR in patients with HAI from tertiary hospital China. We retrospectively evaluated all confirmed diagnosis bacterial infection at general Jining, for period between January 2012 December 2014. following...
Development of new bacterial biofilm inhibitors as antibacterial synergists is an effective strategy to solve the resistance Pseudomonas aeruginosa. In this paper, a series 3-hydroxy-pyridin-4(1H)-ones were synthesized and evaluated, hit compound (20p) was identified with effects inhibiting production pyocyanin (IC50 = 8.6 μM) formation 4.5 μM). Mechanistic studies confirmed that 20p inhibits by expression pqsA, blocking pqs quorum sensing system quinolone biosynthesis. Moreover, we...
The c-rings of ATP synthases consist individual c-subunits, all which harbor a conserved motif repetitive glycine residues (GxGxGxG) important for tight transmembrane α-helix packing. c-ring stoichiometry determines the number ions transferred during enzyme operation and has direct impact on ion-to-ATP ratio, cornerstone parameter cell bioenergetics. In extreme alkaliphile Bacillus pseudofirmus OF4, is replaced by AxAxAxA. We performed structural study two mutants with alanine-to-glycine...
Inflammation and reepithelialization after corneal abrasion are critical for the rapid restoration of vision prevention microbial infections. However, endogenous regulatory mechanisms not completely understood. Here we report that manipulation autonomic nervous system (ANS) regulates inflammation healing processes. The activation sympathetic nerves inhibited but increased influx neutrophils release inflammatory cytokines. Conversely, parasympathetic promoted Furthermore, observed CD64+CCR2+...
2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS), a compound from P. aeruginosa, functions as both quorum sensing (QS) regulator and potent iron chelator to induce expression of pyoverdine pyochelin which are involved in high-affinity transport systems. A potential dual-acting antibiofilm strategy requires molecules designed interfere with uptake the QS system aeruginosa. series 2-substituted 3-hydroxy-1,6-dimethylpyridin-4-ones have been designed, synthesized, tested biofilm inhibitors One...
Migratory birds play an important role in the spread of multidrug-resistant (MDR) bacteria. To investigate prevalence MDR Escherichia coli migratory China and potential relationships with environment, a total 1387 samples (fecal samples, cloacal swabs, or throat swabs) were collected from three different river basins China. The processed subjected to bacteriological examinations. Antimicrobial susceptibility testing recovered isolates was performed using E-test for detection minimum...
Introduction Pulmonary fibrosis (PF) is a chronic and irreversible interstitial lung disease characterized by lack of effective therapies. Mesenchymal stem cells (MSCs) have garnered significant interest in the realm regeneration due to their abundant availability, ease isolation, capacity for expansion. The objective our study was investigate potential therapeutic role umbilical cord-derived MSCs (UC-MSCs) management PF, with focus on alterations gut microbiota its metabolites during use...
The aim of this paper is to explore the technological innovation mechanism by which digital transformation (DT) influences total factor productivity (TFP). We take Chinese listed firms from 2007 2020 as research samples, and con- tribute above goals based on fixed-effect models, instrumental variables, mediation effect, moderating effect models. It has been found that (1) while DT contributes positively productivity, enhancement TFP in current primarily attributed artificial intelligence...
Grain yield and quality are critical factors in agricultural production. This study aimed to investigate the impact of sowing time on wheat identify optimal period for Xinjiang region China. The changes different spring winter varieties were investigated under periods. results showed that late adversely affected yield, especially wheat. For wheat, resulted higher protein content, wet gluten rheological properties, tensile strength, indicating potential improvements with delayed sowing. In...
In mammalian corneal epithelium, mitosis shows a distinct circadian pattern. However, how this pattern is maintained, and it or its disruption influence renewal regeneration remain unclear.C57BL/6 mice were maintained under 12-hour light/12-hour dark (LD), light (LL), dark/12-hour (DD), reversed LD (DL, light; jet-lag defined as shift of 12 hours) conditions. Mitotic cells in epithelium enumerated analyzed via immunofluorescence at different zeitgeber times (ZTs). Expression core clock genes...
Although antibiotics are useful, they can also bring negative effects. We found that antibiotic-treated mice exhibit an alteration in the gene expression profile of corneal tissues and a decrease nerve density. During wound healing, antibiotic treatment was to impair regeneration, effect could be largely reversed by reconstitution gut microbiota via fecal transplant. Furthermore, CCR2- macrophages were participate repair damaged nerves, mice, which transplant, observed. Adoptive transfer...
Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli have been frequently isolated from food-producing animals and pose a serious threat to human health. This study collected 195 ESBL-producing E. isolates 20 chicken farms 3 live-bird markets located in Northeast China (Heilongjiang, Liaoning, Jilin) Jiangsu province February 2011 October 2013. ESBL genes, including blaCTX-M, blaTEM, blaSHV, were detected characterized, the susceptibilities of these strains various antimicrobial...
Abstract The mechanisms of corneal epithelial lesions and delayed wound repair, as well their association with diabetes mellitus, are critical issues for clinical ophthalmologists. To test whether the diabetic condition alters circadian rhythm in a mouse cornea insulin can synchronise clock, we studied effects streptozotocin-induced on mitosis cells, recruitment leukocytes to cornea, expression main core clock genes ( Clock , Bmal1 Per2 Cry1 Rev-erbα ) epithelium. We also assessed possible...
Abscisic acid (ABA) is a crucial phytohormone for the regulation of seed germination. The ABA content seeds regulated by synthesis and catabolic pathways. Coumarin, an important plant allelochemical, can inhibit germination effectively, although whether it involved in during has not been elucidated. For study reported herein, we show that coumarin effectively inhibits rice vivipary. We found gradually decreased water-imbibed activity Oryza sativa 9-cis epoxycarotenoid dioxygenases (OsNCEDs),...
The management of antibiotic-resistant, bacterial biofilm infections in skin wounds poses an increasingly challenging clinical scenario.