A5071874428- Fire dynamics and safety research
- Fire effects on ecosystems
- RNA Research and Splicing
- Neuroscience of respiration and sleep
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- RNA modifications and cancer
- Flame retardant materials and properties
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Forest Biomass Utilization and Management
- Cardiovascular Function and Risk Factors
- Eicosanoids and Hypertension Pharmacology
- Cardiac Ischemia and Reperfusion
Duke University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guizhou University
2024
Anhui Medical University
2024
Guizhou Minzu University
2024
Lactate produced during ischemia-reperfusion injury is known to promote lactylation of proteins, which play controversial roles. By analyzing the lactylomes and proteomes mouse myocardium using mass spectrometry, we show that both Serpina3k protein expression its at lysine 351 are increased upon reperfusion. Both human homolog, SERPINA3, abundantly expressed in cardiac fibroblasts, but not cardiomyocytes. Biochemically, enhances stability. Using knockout mice overexpressing...