Lung cancer is one of the most common malignant tumors that seriously threaten human health. Current evidence suggests heredity contributes to progression lung cancer. To investigate and validate potential genetic associations with risk cancer, we conducted a case-control study including 309 cases 310 controls from Xi'an City, which located in northwest China, genotyped six SNPs five genes, are related metabolic process. Overall, our results show SNP rs10937405 was associated decreased...

Inflammatory gene polymorphisms may be associated with glioma risk. The purpose of this study was to analyze effects certain inflammatory and some clinical factors on patient survival. information 269 patients conceived operation from September 2010 May 2014 decide the 1-, 3-year survival rates according follow-up results age, gender, WHO classification, extent surgical resection, radiotherapy chemotherapy prognosis. Survival distributions were estimated by using Kaplan–Meier method...

The vitamin D receptor (VDR) mediates the immunological function of D3, which activates macrophages, and deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence susceptibility tuberculosis. This study included 217 patients with pulmonary (PTB) 383 healthy subjects a Tibetan Chinese population living near Xi'an. Association analyses SNPs were performed SPSS 17.0 statistical packages, SNP stats software, Haploview software package (version...

Common variants of multiple genes play a role in glioma onset. However, research related to astrocytoma, the most common primary brain neoplasm, is rare. In this study, we chose 21 tagging SNPs (tSNPs), previously reported be associated with risk Chinese case-control study from Xi'an, China, and identified their contributions astrocytoma susceptibility. We found an association susceptibility for two tSNPs (rs6010620 rs2853676) different genes: regulator telomere elongation helicase 1 (RTEL1)...

Breast cancer is a heterogeneous disease which influenced by genetic, environmental, and lifestyle factors. Genetic susceptibility likely to be due variants conferring more moderate risks. To identify alleles, we conducted case–control association study in 185 breast cases 199 controls the Han population. We genotyped 14 tagging single nucleotide polymorphisms previously implicated using Sequenom MassARRAY SNP genotyping method identified rs3734805 ESR1 gene rs2048672 FLJ43663 were...

Cytochrome P450 2C19 (CYP2C19) is a highly polymorphic gene, it codes for protein responsible the metabolism of multiple clinically important therapeutic agents. However, there currently no available data on distribution CYP2C19 mutant alleles in Tibetan population. The aim present study was to identify different and determine their frequencies, along with genotypic whole gene amplified sequenced 96 unrelated, healthy Tibetans from Tibet Autonomous Region China, promoter region, exons,...

This study aimed to investigate genetic polymorphisms of CYP2D6 among healthy Uygur individuals. Genetic could greatly affect activity and lead differences individuals in drug efficacy or side effects. To the population, we directly sequenced whole gene 96 unrelated, volunteers from Xinjiang Autonomous Region screened for variants promoter, intron, exons, 3'UTR.We detected 62 CYP2D6, 16 which were novel SNP with three non-synonymous mutations first time. The allelic frequencies CYP2D6*1,...

Lung cancer is the leading cause of cancer-related deaths worldwide that result from combined effected smoking exposure and genetic susceptibility. CHRNA3, a nicotinic acetylcholine receptor gene, was associated with lung risk. The aim this study to identify whether CHRNA3 polymorphisms increase risk directly or indirectly through behavior in Chinese Han individuals. We conducted case-control including 228 individuals 301 healthy Seventeen known SNPs within were selected for genotyping. Odds...

BACKGROUND:Genetic polymorphisms have a potential clinical role in determining both inter-individual and inter-ethnic differences drug efficacy, but we not found any pharmacogenomics information regarding minorities, such as the Miao ethnic group. Our study aimed to screen numbers of group for genotype frequencies VIP variants determine between other human populations worldwide. MATERIAL AND METHODS:In this study, genotyped 66 Very Important Pharmacogene (VIP) selected from PharmGKB 98...

Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study examine potential association CLPTM1L single nucleotide polymorphisms (SNPs) with in Chinese Han population. We selected four SNPs gene that reported be associated cancer. Odds ratios (ORs) 95 % confidence intervals (CIs) calculated estimate strength relationship between each SNP...

Current evidence suggests that heredity and metabolic syndrome contribute to gout progression.SLC2A9 ZNF518B may play a role in progression different populations, but no studies have focused on the Tibetan Chinese population.In this study, we ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 14 (3): 9915-9921 (2015) determined whether variations these 2 genes were correlated with gout-related indices Chinese-Tibetan patients.We detected 6 single nucleotide polymorphisms SLC2A9 319...

Gout is the most common form of inflammatory arthritis affecting men, and current evidence suggests that genetic factors contribute to its progression.As a previous study identified WD40 repeat protein 1 (WDR1) associated with gout in populations European descent, we sought investigate relationship this disease Han Chinese population.We genotyped six WDR1 single nucleotide polymorphisms 143 cases 310 controls using ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 15 (2):...

// Xue He 1, 2, 3, * , Xikai Zhu Lei Li 4, 5 Jiayi Zhang 6 Ruipeng Wu 3 Yuan Longli Kang Dongya Tianbo Jin 1 Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China 2 Basic Life Science Environment Gene Related to Ministry Education, Xianyang Shaanxi, 4 Department Thoracolumbar Spine Surgery, Second Affiliated Hospital Inner Mongolia Medical Hohhot...

Genetic polymorphisms of very important pharmacogenomic (VIP) variants are for personalized medicine.However, these have not been extensively studied in the Tibetan population.In this study, 82 VIP were detected and Han (HAN) populations from northwestern China.Subsequently, we compared differences between population ten populations, including HAN, Japanese Tokyo (JPT), Mexican ancestry Los Angeles (MEX), Toscans Italy (TSI), African Southwest USA (ASW), Luhya California Webuye, Kenya (LWK),...

Genetic variations in cytochrome P450 2C9 are known to contribute interindividual and interethnic variability response clinical drugs, but little is about the genetic variation of CYP2C9 Uyghur population.We directly sequenced whole gene 96 unrelated, healthy from Xinjiang Uygur Autonomous Region China screened for variants promoter, exons, introns 3′-UTR.Thirty five previously reported alleles six genotypes were detected this study. The allele frequencies CYP2C9*1, *2, *11, *12, *29 *33...

Within a population, the differences of pharmacogenomic variant frequencies may produce diversities in drug efficacy, safety, and risk associated with adverse reactions. With development pharmacogenomics, widespread genetic research on metabolism has been conducted major populations, but less is known about minorities.In this study, we recruited 100 unrelated, healthy Mongol adults from Xinjiang genotyped 85 VIP variants PharmGKB database. We compared our data eleven populations listed 1000...