A5018522592- Systemic Lupus Erythematosus Research
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- Neurological Complications and Syndromes
- Moyamoya disease diagnosis and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Brain Metastases and Treatment
- Corporate Insolvency and Governance
- Advanced Electron Microscopy Techniques and Applications
- Ferroptosis and cancer prognosis
- Advanced Nanomaterials in Catalysis
- Regional Development and Environment
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Intuitionistic Fuzzy Systems Applications
- Adrenal and Paraganglionic Tumors
- Intracerebral and Subarachnoid Hemorrhage Research
- Autoimmune and Inflammatory Disorders Research
First Hospital of Jilin University
2016-2024
Jilin University
2016-2024
First Bethune Hospital of Jilin University
2019-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
Sixth Affiliated Hospital of Kunming Medical University
2021-2023
Kunming Medical University
2021-2023
Nanjing Medical University
2019-2022
Beijing Chaoyang Emergency Medical Center
2022
Anhui Science and Technology University
2018
Ischemic stroke caused by a thrombus clog and ischemia is one of the most lethal disabling cerebrovascular diseases. A sequentially targeted delivery system highly desired to deliver thrombolytics neuroprotectant site ischemic penumbra, respectively, pursue maximized combinational effect. Inspired vital roles that platelets play in formation, herein, we develop bioengineered "nanoplatelet" (tP-NP-rtPA/ZL006e) for site-specific recombinant tissue plasminogen activator (rtPA) (ZL006e)...
Glioma is the most lethal brain tumor with a poor prognosis, and combination of multiple therapeutic strategies critical for postoperative glioma treatment. Herein, multifunctional hybrid hydrogel system (designated as CP&CL@RNPPTX-Gel) was developed local treatment glioma. The composed self-illuminating chlorin e6 (Ce6) conjugated luminol molecule (CL)-loaded glioma-targeting paclitaxel prodrug nanoparticles copper peroxide nanodots (CP NDs) coembedded into three-dimensional thermosensitive...
We investigated the effects and targets of gastrodin (GAS) for improving cognitive ability in Alzheimer's disease (AD).
Abstract Atherosclerosis (AS) is one of the most common chronic inflammatory diseases and a major cause morbidity mortality. However, underlying molecular mechanisms progression AS are still largely unknown. Increasing evidence has demonstrated that long noncoding RNAs (lncRNAs) play important roles in variety biological processes physiological pathological human diseases. In this study, we aimed to explore role mechanism lncRNA MEG3 Raw264.7 cells treated with oxidized low‐density...
Tumor-associated neutrophil extracellular traps (NETs) play a critical role in promoting tumor growth and assisting metastasis. Herein, smart nanocarrier (designated as mP-NPs-DNase/PTX) based on regulating tumor-associated NETs has been developed, which consists of paclitaxel (PTX) prodrug nanoparticle core poly-l-lysine (PLL) conjugated with the matrix metalloproteinase 9 (MMP-9)-cleavable Tat-peptide-coupled deoxyribonuclease I (DNase I) shell. After accumulating at site tissue, can...
Currently, the treatment of brain metastases from non-small cell lung cancer (NSCLC) is rather difficult in clinic. A combination small molecule-targeted drug and chemo-drug a promising therapeutic strategy for NSCLC metastases. But efficacy this therapy not satisfactory due to blood-brain barrier (BBB). Therefore, it urgent develop delivery system enhance synergistic effects metastases.T7 peptide installed osimertinib (AZD9291) loaded intracellular glutathione (GSH) responsive doxorubicin...
Background: The use of antiplatelet agents in ischemic moyamoya disease (MMD) is controversial. This study aimed to investigate the effectiveness and safety therapy compared with conservative treatment surgical revascularization MMD patients. Methods: Ischemic patients were retrospectively enrolled from eight clinical sites January 2013 December 2018. Follow-up was performed through visits and/or telephone interviews first discharge 2019. primary outcome episodes further attacks, secondary...
Recent observational studies have reported the association between ischemic stroke (IS) and cerebral microbleeds (CMBs). Whether this reflects a causal remains to be established. Herein, we adopted two-sample bidirectional Mendelian randomization (MR) analysis comprehensively evaluate of IS CMBs.The summary-level genome-wide (GWASs) data were obtained from GIGASTROKE consortium (62,100 European ancestry cases 1,234,808 controls). All could further divided into large-vessel atherosclerosis...
The optimal treatment choice of chronic carotid artery occlusion (CAO) remains inconclusive. This study was aimed at exploring the safety and effectiveness hybrid surgery in CAO determining predictors for successful recanalization.In this study, we enrolled 37 patients with who underwent surgical during period 2016-2018. We extracted analyzed patients' demographic data, disease characteristics, success rates, perioperative complications, prognosis.A total symptomatic treatment. Thirty cases...
Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with substantial phenotypic heterogeneity. Currently, our understanding of the pathogenesis still limited, and as result, specific efficacious therapies are lacking. Various mouse models have been established to serve powerful tools that will promote better ability test novel drugs before clinical application.Areas covered The authors review existing SLE in terms manifestations, well their applications drug...
Objective: To investigate risk factors of rupture internal carotid artery resection during body tumor and to summarize our treatment experience. Methods: During the period from 1991 2016, occurred in 27 patients (28 tumors) surgical First Affiliated Hospital Sun Yat-sen University. Their clinical follow-up data were retrospectively collected analyzed. For all underwent this period, Logistic regression analysis was used intraoperative artery. Results: Of these 28 tumors, there 15 (53.6%)...
Tripterygium wilfordii Hook F (TWHF) is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus (SLE), with triptolide (TP) as its main active ingredient. However, side effects also induced by TP, especially hepatotoxicity and reproductive toxicity, largely limit application subset patients. Monoclonal antibodies (mAbs) developed for SLE that deplete B cells targeting cell-expressing antigens, such CD19, have failed clinical trials, partly due to their...
Purpose: Currently, there is no uniform standard to guide postoperative adjuvant chemotherapy for patients with multifocal non-small cell lung cancers (NSCLCs) ≤ 3 cm. Therefore, an urgent need explore prognostic molecular markers identify high-risk NSCLCs We aimed the potential value of metastasis-associated protein 1(MTA1) expression in risk stratification Methods: retrospectively analyzed clinical data and survival Paraffin-embedded tissue sections were used immunohistochemistry....
The group cooperative learning method is applied to the teaching of hydrodynamics. Two examples are given, and effect applying analyzed. It was proved that can effectively improve enthusiasm learners actual effect, it learners’ communication cooperation, self-study ability etc.
Background: Studies exploring the predictive performance of major risk factors associated with future stroke events are insufficient, and a useful tool to predict individual is not available. Therefore, personalized advice for preventing in patients moyamoya disease (MMD) cannot provide evidence-based recommendations. The aim this study was develop novel nomogram reliable validity adult MMD patients. Methods: This included 450 from seven medical centers between January 2013 December 2018....
Abstract Purpose The specific regulatory mechanism of neutrophil extracellular traps (NETs) in lung adenocarcinoma (LUAD) is unclear. Methods LUAD related datasets were obtained via the cancer genome atlas (TCGA) and gene expression omnibus (GEO) databases. Differentially expressed genes (DEGs) between control samples sifted out, critical modules yielded weighted co-expression network analysis (WGCNA). NETs score TCGA-LUAD set was estimated based on 136 genes. Further, DEGs1 high/low scoring...
Protecting the interests of creditors is key to improve business environment our country. However, current law country weak protect creditors. When an enterprise enters bankruptcy procedures, game between and enterprises exists at various stages bankruptcy. small often have less voice in creditors' meeting, large more decision-making power making as core meeting causing serious damage Based on process corporate bankruptcy, this paper analyzes inadequacy protection each stage after puts...
Abstract BACKGROUND: CYP2C19 polymorphisms are associated with the increased risk of major adverse cardiovascular/cerebrovascular events (MACCEs) in cerebral intervention. In this study, we wanted to investigate whether polymorphism and other nongenetic factors can influence incidence MACCEs artery stenosis disease patients. METHODS: A total 164 patients underwent stenting 138 conservative treatment among 1406 who gene screening were enrolled study. Cox proportional hazards model...