A5100632446- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Plant Pathogens and Fungal Diseases
- Genetics and Neurodevelopmental Disorders
- Mycorrhizal Fungi and Plant Interactions
- Bioinformatics and Genomic Networks
- Congenital Heart Disease Studies
- Autism Spectrum Disorder Research
- Anesthesia and Sedative Agents
- Research in Cotton Cultivation
- Congenital heart defects research
- Connective tissue disorders research
- Software Engineering Research
- Advanced Proteomics Techniques and Applications
- Software Reliability and Analysis Research
- Plant-Microbe Interactions and Immunity
- Software Engineering Techniques and Practices
- Gene expression and cancer classification
- Genomics and Rare Diseases
- Anesthesia and Neurotoxicity Research
- Genomic variations and chromosomal abnormalities
- Fungal Biology and Applications
- Photosynthetic Processes and Mechanisms
- Autopsy Techniques and Outcomes
- Ubiquitin and proteasome pathways
MedStar Health
2024
MedStar Union Memorial Hospital
2024
European Bioinformatics Institute
2022-2023
Antwerp University Hospital
2016-2022
University of Antwerp
2016-2022
University of Cambridge
2020-2022
National Botanical Research Institute
2021-2022
Open Targets
2022
Wellcome/MRC Cambridge Stem Cell Institute
2020
Biomedical Informatics Research Center Antwerp
2018
Bicuspid aortic valve (BAV) is the most common congenital heart defect. Although many BAV patients remain asymptomatic, at least 20% develop thoracic aneurysm (TAA). Historically, BAV-related TAA was considered as a hemodynamic consequences of Multiple lines evidence currently suggest that genetic determinants contribute to pathogenesis both and in affected individuals. Despite high heritability, only very few genes have been linked BAV/TAA, such NOTCH1, SMAD6 MAT2A. Moreover, they explain...
The genome of tomato ( Solanum lycopersicum L.) is being sequenced by an international consortium 10 countries (Korea, China, the United Kingdom, India, Netherlands, France, Japan, Spain, Italy, and States) as part larger “International Solanaceae Genome Project (SOL): Systems Approach to Diversity Adaptation” initiative. sequencing project uses ordered bacterial artificial chromosome (BAC) approach generate a high‐quality euchromatic sequence for use reference euasterids. Sequence deposited...
Taphrina deformans is a fungus responsible for peach leaf curl, an important plant disease. It phylogenetically assigned to the Taphrinomycotina subphylum, which includes fission yeast and mammalian pathogens of genus Pneumocystis. We describe here genome T. in light its dual plant-saprophytic/plant-parasitic lifestyle. The 13.3-Mb contains few identifiable repeated elements (ca. 1.5%) relatively high GC content (49.5%). A total 5,735 protein-coding genes were identified, among 83% share...
Computational gene prioritization can aid in disease identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive scalable tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian Human Phenotype Pathway, Interactions, Disease Association database Genome Epidemiology database, into the prediction model. We explore address effects of sparsity inter-feature dependencies within annotation...
Background and Aims: Premedication is an integral component of paediatric anaesthesia which, when optimal, allows comfortable separation the child from parent for induction conduct anaesthesia. Midazolam has been accepted as a safe effective oral premedicant. Dexmedetomidine selective alpha-2 agonist with sedative analgesic effects, which through transmucosal route. We compared efficacy safety standard premedication midazolam versus intranasal dexmedetomidine in children undergoing elective...
To facilitate early deployment of whole-genome sequencing (WGS) for severely ill children, a standardized pipeline WGS analysis with timely turnaround and primary care pediatric uptake is needed. We developed bioinformatics comprehensive gene-agnostic trio children suspected having an undiagnosed monogenic disease that included detection interpretation genetic mechanisms disease, including SNVs/indels, CNVs/SVs, uniparental disomy (UPD), imprinted genes, short tandem repeat expansions,...
Cotton fiber development is still an intriguing question to understand commitment and development. At different developmental stages, many genes change their expression pattern have a pivotal role in quality yield. Recently, numerous studies been conducted for transcriptional regulation of fiber, raw data were deposited the public repository comprehensive integrative analysis. Here, we remapped > 380 cotton RNAseq with uniform mapping strategies that span ∼400 fold coverage genome. We...
Background Although carpal tunnel syndrome (CTS) is the most common form of peripheral entrapment neuropathy, its pathogenesis remains largely unknown. An estimated heritability index 0.46 and an increased familial occurrence indicate that genetic factors must play a role in pathogenesis. Methods results We report on family which CTS occurred subsequent generations at unusually young age. Additional clinical features included brachydactyly short Achilles tendons resulting toe walking...
Gene Ontology (GO) is a popular standard in the annotation of gene products and provides information related to genes across all species. The structure GO dynamic updated on daily basis. However, existing methods use outdated versions GO. Moreover, these tools are slow process large datasets consisting more than 20,000 genes. We have developed GOParGenPy, platform independent software tool generate binary data matrix showing class membership, including parental classes, set annotated...
The prevalence of premature atherosclerotic cardiovascular disease (ASCVD) ranges from 7% to 30%, but the incidence in young patients is increasing. Traditional risk factors, such as hypertension, hyperlipidemia, obesity, and diabetes, have an increasing especially women. A 32-year-old woman presented with dyspnea exertional chest pain. She had a history familial hypercholesterolemia unidentified aortic valve status after pulmonary autograft at age 20. Due insurance changes onset COVID-19...
Fungi have an important role in the biodegradation of monuments made stone. The effect fungi degradation different types stone has been widely investigated and demonstrated. can provide bio-protection for surfaces, act as a barrier against weathering, retain moisture, increase waterproofing, reduce thermal stress corrosion, absorb pollutants. Nevertheless, evaluation versus bio-preservation cannot be generalized, it may vary according to behavior species, well that influenced by both...
Abstract Pyomyositis is an acute pyogenic infection of the muscles and tissues which results in localized pus collections abscess formation. This entity at times becomes difficult to diagnose due lack specific signs atypical or nonspecific manifestations. condition a mimic for wide range differential diagnoses patient often receives many unwarranted antibiotics. Furthermore, deep location makes clinical apparent leading misdiagnosis as rarer entities such inflammatory myositis. In last 1...
Computational identification of copy number variants (CNVs) in sequencing data is a challenging task. Existing CNV-detection methods account for various sources variation and perform different normalization strategies. However, their applicability predictions are restricted to specific enrichment protocols. Here, we introduce novel tool named varAmpliCNV, specifically designed amplicon-based targeted resequencing (Haloplex™ protocol) the absence matched controls. VarAmpliCNV utilizes...
Summary Cotton fiber development is still an intriguing question to understand the commitment and development. Here, we remapped >350 publicly available cotton RNA sequencing data on recently published genome with ∼400 fold coverage. The differentially expressed genes were clustered in six modules whose functions are specific commitment, initiation, elongation Secondary Cell Wall (SCW) stages. Gene Ontology analysis of initiation suggests enrichment involved organ for SCW showed...
Software development process involves developing, building and enhancing high-quality software for specific tasks as a consequence generates considerable amount of data. This data can be managed in systematic manner creating knowledge repositories that used to competitive advantage. Lesson's learned part the also bank advantage subsequent projects by developers practitioners. Code smells are group symptoms which reveal code is not good enough requires some actions have cleansed code. metrics...