A5030103279- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- HER2/EGFR in Cancer Research
- Functional Brain Connectivity Studies
- Tissue Engineering and Regenerative Medicine
- Nicotinic Acetylcholine Receptors Study
- Mental Health Research Topics
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Endometrial and Cervical Cancer Treatments
- Cancer, Lipids, and Metabolism
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
Shanghai First Maternity and Infant Hospital
1996-2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Zhejiang University
2016-2022
Tumor microenvironment (TME) is emerging as an essential part of cervical cancer (CC) tumorigenesis and development, becoming a hotspot research these years. However, comprehending the specific composition TME still facing enormous challenges, especially immune stromal components. In this study, we downloaded RNA-seq profiles somatic mutation data 309 CC cases from The Cancer Genome Atlas (TCGA) database, which were analyzed by integrative bioinformatical methods. Initially, ESTIMATE...
Cervical cancer (CC) has long been a concern, as gynecological type of high-risk. At present, there are few studies on the early detection CC at genetic level. The breakthrough is to recognize patients tending have worse prognosis by checking expression pattern ferroptosis-related genes, which enjoy great potential being applied treatment. Data used in this study was obtained from series public online databases, integrated with gene collection stored FerrDb database and GeneCards database....
Abstract Background Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) demonstrated unprecedented potential in treatment POF. However, heterogeneity human UC-MSCs remains challenge for their large-scale clinical application. Therefore, it is imperative to identify specific subpopulations within that possess capability improve function, with aim...
The cross-talk between tumor cells and the microenvironment (TME) is an important factor in determining tumorigenesis progression of cervical cancer (CC). However, clarifying potential mechanisms which trigger above biological processes remains a challenge. present study focused on immune-relevant differences at transcriptome somatic mutation levels through integrative multi-omics analysis based Cancer Genome Atlas database. objective was to recognize specific immune-related prognostic...
Ovarian cancer (OC) is one of the most malignant tumors whose mortality rate ranks first in gynecological tumors. Although immunotherapy sheds new light on clinical treatments, low response still restricts its use because unique characteristics OC such as immunosuppressive microenvironment and unstable genomes. Further exploration determining an efficient biomarker to predict patients vital importance. In this study, integrative analyses were performed systematically using transcriptome...
Cervical cancer (CC) is a malignancy that tends to have poor prognosis when detected at an advanced stage; however, there are few studies on the early detection of CC genetic level. The tumor microenvironment (TME) and genomic instability (GI) greatly affect survival patients via effects carcinogenesis, growth, resistance. It necessary identify biomarkers simultaneously correlated with components TME GI, as these could predict efficacy immunotherapy. In this study, we extracted somatic...
Background Acute liver injury is a disease characterized by severe dysfunction, caused significant infiltration of immune cells and extensive cell death with high mortality. Previous studies demonstrated that the α7 nicotinic acetylcholine receptor (α7nAChR) played crucial role in various diseases. The hypothesis this study was activating α7nAChR could alleviate acute investigate its possible mechanisms. Methods induced intraperitoneal injection lipopolysaccharide (LPS)/D-galactosamine...
Background: Cervical cancer (CC) is a serious threat to women populations worldwide. Lipid metabolism believed have modulating functions in cancer. Long non-coding RNAs (lncRNAs) are potential biomarkers for the different tumor prognosis. Our work aims at investigating prognostic value of lipid metabolism-related lncRNAs CC. Methods: LncRNA expression profiling was conducted 291 patients from The Cancer Genome Atlas (TCGA). Patient samples were randomly assigned training or testing set 3:2...
<title>Abstract</title> Objective In the dynamic landscape of cervical cancer (CC) pathophysiology, this study aimed to elucidate role necroptosis in modulating tumor proliferation, invasion, and immune microenvironment CC. Methods study, impact on CC was evaluated through a series bioinformatical analyses experimental approaches. The illustrated by analyzing its effects aggression, responses, JAK2-STAT3 signaling pathway. Bevacizumab, monoclonal antibody targeting vascular endothelial...
In the dynamic landscape of cervical cancer (CC) pathophysiology, this study aimed to elucidate role necroptosis in modulating tumor proliferation, invasion, and immune microenvironment CC. study, impact on CC was evaluated through a series bioinformatical analyses experimental approaches. The illustrated by analyzing its effects aggression, responses, JAK2-STAT3 signaling pathway. Bevacizumab, monoclonal antibody targeting vascular endothelial growth factor (VEGF), also for potential...
Abstract Objective : To determine the amplification of proto‐oncogene HER‐2/ neu in invasive cervical cancer and its relationship with stage disease, grade tumor prognosis patients. Methods In this retrospective study 70 women squamous cell carcinoma were included. DNA was extracted from paraffin‐embedded tissue. The studied using a differential polymerase reaction (PCR) technique. Assessment significance performed Peason's Chi‐square test Fisher's exact test. Results Eleven cases (16%)...