A5057402045- Alcohol Consumption and Health Effects
- Medicinal plant effects and applications
- Liver Disease Diagnosis and Treatment
- Hops Chemistry and Applications
- Diet, Metabolism, and Disease
- Food Quality and Safety Studies
- Drug-Induced Hepatotoxicity and Protection
- Insect Utilization and Effects
- Oral and Maxillofacial Pathology
- Pancreatic function and diabetes
- Hedgehog Signaling Pathway Studies
- Photoacoustic and Ultrasonic Imaging
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- Sesquiterpenes and Asteraceae Studies
- Ginkgo biloba and Cashew Applications
- RNA Research and Splicing
- Aldose Reductase and Taurine
- Biochemical Acid Research Studies
- Bipolar Disorder and Treatment
- Renal Diseases and Glomerulopathies
- RNA regulation and disease
- Gout, Hyperuricemia, Uric Acid
- Inflammatory Bowel Disease
- interferon and immune responses
Zhejiang Chinese Medical University
2015-2024
Nanjing University of Chinese Medicine
2014-2024
Shanghai First People's Hospital
2024
First Affiliated Hospital of Chengdu Medical College
2021
Sichuan University
2008
West China Hospital of Sichuan University
2008
Phellinus igniarius (P. igniarius) is a medicinal fungus that widely used in East Asia for the adjuvant treatment of cancer. To elucidate antitumor effective substances and mechanism P. igniarius, we designed an approach incorporating cytotoxicity screening, phytochemical analysis, network pharmacology construction, cellular molecular experiments. The dichloromethane extract (DCMPI) was identified as active portion HT-29 cells. Nineteen constituents were identified, 5 quantified by...
Colitis-associated colorectal cancer (CAC) is a specific type of (CRC) with high mortality and morbidity, the chronic inflammation in intestinal mucosal characteristic CAC. Chang Qing formula (CQF) Chinese herbal used clinically for treatment CAC remarkable clinical efficacy, but its mechanism remains unclear. In present work, Combined network pharmacology transcriptomics were to analyze potential active ingredients elucidate molecular CQF treating Firstly, constituents migrating blood...
This study aimed to investigate the effects of Compound Ginkgo biloba (CGB) on alterations in intestinal permeability and inflammation caused by endotoxin chronic alcohol-induced liver injury. CGB was prepared extract Rosa roxburghii a 1 : proportion. Rats were divided into four groups: control, ethanol, high-dosage (0.6 g kg(-1) d(-1)) low-dosage (0.2 group. control group ingested Lieber-DeCarli liquid diet, while rats ethanol CGB-treated groups alcohol diet for eight weeks. orally...
Lupus nephritis (LN) is one of the most serious complications systemic lupus erythematosus (SLE) and leading causes death. An alternative effective treatment to ameliorate relieve LN delay process renal tissue fibrosis urgently needed in clinical setting. Jieduquyuziyin prescription (JP) has been successfully used treat SLE, but its potential mechanisms are not sufficiently understood. In this study, we treated MRL/lpr mice with JP for 8 weeks human tubular epithelial cells (human kidney 2...
Symmetrical dimethylarginine (ADMA) endogenously inhibits nitric oxide synthase (NOS) and strongly indicates oxidant stress, whose formation primarily derived from type 1 protein arginine N-methyltransferase (PRMT1) metabolism was governed by dimethylaminohydrolase (DDAH1). This study aimed to evaluate participation of the PRMT1-ADMA-DDAH1 axis in kidneys 2 diabetes model rats human subjects, effect probucol on this renal function.A total 30 were randomly assigned a normal group (NC, n=10),...
Our previous study indicated that herbal SGR formula partially attenuates ethanol-induced fatty liver, but the underlying mechanisms remain unclear. In present study, mice were pretreated with (100 and 200 mg/kg/d bw) for 30 d before being exposed to ethanol (4.8 g/kg bw). The biochemical indices histopathological changes examined evaluate protective effects explore potential by investigating adiponectin, tumor necrosis factor-α (TNF-α), peroxisome proliferators-activated receptor-α...
Abstract Objective This study aimed to the clinical efficacy of polyene phosphatidyl choline (PPC) injections was assessed using data from Nanjing Hospital Chinese Medicine. Then investigate mechanisms PPC in prevention and treatment alcoholic liver disease (ALD) mice. Methods First, Medicine Modernization Big Data Research Center at were collected analyzed assess effects injections. Then, a mouse model injury established C57BL/6J The protective against ALD evaluated systemic level...