A5077597404- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- Rheumatoid Arthritis Research and Therapies
- Medicinal plant effects and applications
- Fibroblast Growth Factor Research
- Wound Healing and Treatments
- Ovarian function and disorders
- Protease and Inhibitor Mechanisms
- Inflammasome and immune disorders
- Tendon Structure and Treatment
- Total Knee Arthroplasty Outcomes
- Coronary Interventions and Diagnostics
- Diabetes Treatment and Management
- Inflammatory Bowel Disease
- Hops Chemistry and Applications
- Knee injuries and reconstruction techniques
- Autoimmune and Inflammatory Disorders
- Biosensors and Analytical Detection
- Pharmacological Effects of Medicinal Plants
- Mycobacterium research and diagnosis
- Liver physiology and pathology
- Gout, Hyperuricemia, Uric Acid
- Wnt/β-catenin signaling in development and cancer
- Microfluidic and Bio-sensing Technologies
Nordic Bioscience (Denmark)
2016-2024
Xuzhou Medical College
2024
University of Copenhagen
2017-2020
Guangdong Provincial Hospital of Traditional Chinese Medicine
2020
Guangzhou University of Chinese Medicine
2017-2020
Zhejiang Chinese Medical University
2017-2018
Background and Aims During fibrogenesis, in which excessive remodeling of the extracellular matrix occurs, both quantity type VI collagen levels metalloproteinases, including MMP-2 MMP-9, increase significantly. Proteolytic degradation into small fragments, so-called neo-epitopes, may be specific biochemical marker liver fibrosis. The aim this study was to develop an ELISA detecting a fragment generated by evaluate assay two preclinical models Methods Mass spectrometric analysis cleaved...
Abstract Background Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA loss cartilage; however, it evident that the rate cartilage differs among patients, which may partly be attributed to differential capacity for repair. We hypothesize low repair endotype exists and such endotypes are more likely progress radiographically. The aim this study examine associations level formation severity radiographic progression. used blood-based marker PRO-C2, reflecting type II...
N-terminal propeptide of type II collagen (PIINP) is a biomarker reflecting cartilage formation. PIINP exists in two main splice variants termed as IIA and IIB NH2-propeptide (PIIANP, PIIBNP). PIIANP has been widely recognized formation biomarker. However, the utility PIIBNP marker preclinical clinical settings not fully investigated yet. In this study, we aimed to characterize an antibody targeting human develop immunoassay assessing synthesis blood samples. A high sensitivity...
Osteoarthritis (OA) is characterized by the gradual loss of cartilage. Sprifermin, a recombinant FGF18, being developed as cartilage anabolic drug. PRO-C2 serum marker type II collagen formation and low levels have been shown to be prognostic radiographic progression. The aim study was investigate whether patient groups with either high or responded differently sprifermin.PRO-C2 measured in synovial fluid (SF) (n = 59) samples 225) from participants FORWARD study, 2-year phase IIb clinical...
Background & Aims: Crohn’s disease (CD) is a chronic inflammatory condition characterized by continuous mucosal damage and ongoing wound healing of the intestines. The fibrinolytic system involved in early parts process. Fibrin key mediator primary blood clot formation formed cross-linking fibrinogen. To gain insights into dynamics CD patients we investigated conversion fibrinogen fibrin pro-peptide FPA, amount factor XIII cross-linked total clot. Methods: Serum samples 35 patients, 15...
C-telopeptide of type II collagen (CTX-II) has been shown to be a highly relevant biomarker cartilage degradation in human rheumatic diseases, if measured synovial fluid or urine. However, serum plasma CTX-II have not demonstrated any clinical utility date. Here, we describe the GPDPLQ1237 ELISA which targets EKGPDPLQ↓ neo-epitope, an elongated version neo-epitope (EKGPDP↓), speculated blood-precursor generated by cysteine protease cathepsin K. Human osteoclast resorption cultures as well...
To investigate type III collagen (COL III) turnover in participants from the CANVAS Program biomarker substudy.
Abstract Background The modified polycystic ovary syndrome health-related quality-of-life questionnaire (MPCOSQ) is a 30-item instrument measuring in English-speaking patients with (PCOS). We aimed to: 1) cross-culturally adapt the MPCOSQ into Chinese, and 2) assess validity reliability of Chinese version (Chi-MPCOSQ). Methods was translated using forward-backward method, its were assessed among 283 PCOS. Internal consistency test-retest by Cronbach’s α intra-correlation coefficient (ICC),...
Type II collagen is the most abundant protein of articular cartilage. The urinary cross-linked C-terminal telopeptide type (uCTX-II) a matrix metalloproteinase (MMP) cleaved fragment and may be well-validated biomarker in osteoarthritis. aim was to develop serological immunoassay CTX-II (sCTX-II) evaluated both sCTX-II uCTX-II levels cross-sectional osteoarthritis cohort.
Loss of volume in the temples is an early sign aging and often gives impression a gaunt emaciated appearance. The authors conduct clinical study to investigate safety effectiveness amino acid crosslinked hyaluronic (ACHA) for treatment temple hollowing. 75 subjects with Temple Hollowing Scale (THS) from 2 4 were enrolled assigned according ratio (ACHA group, n = 50): 1 (no control 25). All assessed at 12-month follow-up visit using THS, Global Aesthetic Improvement (GAIS), ultrasound,...