A5045220012- Lung Cancer Treatments and Mutations
- Beetle Biology and Toxicology Studies
- Autophagy in Disease and Therapy
- Antimicrobial Peptides and Activities
- Ginseng Biological Effects and Applications
- Lung Cancer Research Studies
- Computational Drug Discovery Methods
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Enzyme function and inhibition
- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
- Phytochemical compounds biological activities
- Phytochemistry and Biological Activities
- Cancer-related gene regulation
- Mycobacterium research and diagnosis
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Quinazolinone synthesis and applications
- Histone Deacetylase Inhibitors Research
- Cytokine Signaling Pathways and Interactions
Bengbu Medical College
2020-2022
Lung cancer has the highest mortality rate among all types. In combination with multiple chemotherapeutic options, traditional Chinese medicine proven indispensable for comprehensive treatment of lung cancer. To investigate effects Hedyotis diffusa on adenocarcinoma cell lines and a BALB/c nude mouse xenograft model, determine whether HDI could induce ferroptosis in cells along underlying mechanism. The anti-tumor activity was determined vitro by counting kit-8, clonogenic, transwell assays....
Roughly one third of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-sensitive mutated (EGFRm) tumors experience disease progression through central nervous system (CNS) metastases during treatment. Although EGFR-TKIs have been reported to be favored in some EGFRm NSCLC CNS metastases, novel proven efficacy pathologies are clinically needed.To investigate whether almonertinib, a third-generation EGFR-TKI for NSCLC, can...
Almonertinib, a new third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is highly selective to EGFR T790M-mutant non-small cell lung cancer (NSCLC). However, there no available information on the form and molecular mechanism of Almonertinib-induced death in NSCLC cells. Herein, CCK-8 colony formation assays, flow cytometry, electron microscopy, western blots assay showed that Almonertinib inhibited cells proliferation by inducing apoptosis autophagy which can...
To explore the molecular mechanism mediating inhibitory effect of Chuanxiong Rhizoma against brain metastasis lung cancer using network pharmacology methods and docking.The chemical components their targets were obtained through Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. The relevant for screened GeneCards Clusterpro-filerR package was used to perform GO KEGG enrichment analysis. Cytoscape STRING database construct "active ingredient-target-disease" protein-protein...
To assess the changes in effects of cantharides after alkaline processing on proliferation, migration, invasion, and apoptosis human lung cancer A549 cells.Human non-small cell cells were treated with cantharis extract (CTE) from raw alkali processed (ACE). The proliferation was detected CCK-8 assay, migration invasion assessed using wound healing assay Transwell respectively. expressions MMP1 MMP2 Western blotting, contents IFN-γ, IL-1β TNF-α measured ELISA, analyzed annexinV/PI fluorescent...
Ethnopharmacological relevance: Patients with non-small cell lung cancer (NSCLC) in the East Asian population tend to harbor epidermal growth factor receptor (EGFR) mutations and have a particularly high incidence of brain metastasis. Treatment metastatic EGFR-tyrosine kinase inhibitors is hindered by their limited permeability across blood-brain barrier. Wine-processed Chuanxiong Rhizoma (WCR), dried rhizome Ligusticum chuanxiong Hort., used as meridian-guiding drug Traditional Chinese...
Background: Lung cancer has the highest mortality rate among all types. Traditional Chinese medicines with heat clearing and detoxification efficacy have been extensively studied for treatment of lung cancer. However, inhibitory effect Hedyotis diffusa Willd (HDW), efficacy, on underlying mechanism remain unclear. Objective: To explore potential action HDW in based network pharmacology molecular docking techniques. Methods: The pharmacological database traditional medicine system analysis...