A5006284903- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Circadian rhythm and melatonin
- Dermatology and Skin Diseases
- Advanced MRI Techniques and Applications
- Chemical and Physical Studies
- Natural Compounds in Disease Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- EEG and Brain-Computer Interfaces
- Contact Dermatitis and Allergies
- Neuroscience and Neural Engineering
- Genetics and Neurodevelopmental Disorders
- Pharmacological Effects and Toxicity Studies
- Neural dynamics and brain function
- Neurological disorders and treatments
- Renal and related cancers
- Fractal and DNA sequence analysis
- Blind Source Separation Techniques
Florida International University
2023-2024
Albert Einstein College of Medicine
2017-2024
University of Alabama at Birmingham
2021-2023
Virginia Tech
2017-2021
Biomedical Research Institute
2019-2021
Carilion Clinic
2017-2019
Odessa National Medical University
2015
Focal traumatic brain injury (TBI) induces astrogliosis, a process essential to protecting uninjured areas from secondary damage. However, astrogliosis can cause loss of astrocyte homeostatic functions and possibly contributes comorbidities such as posttraumatic epilepsy (PTE). Scar-forming astrocytes seal focal injuries off healthy tissue. It is these glial scars that are associated with originating in the cerebral cortex hippocampus. vast majority human TBIs also present diffuse caused by...
Mild traumatic brain injury/concussion (mTBI) accounts for 70-90% of all reported TBI cases and causes long-lasting neurological consequences in 10-40% patients. Recent clinical studies revealed increased blood-brain barrier (BBB) permeability mTBI patients, which correlated with secondary damage after mTBI. However, the cascade cellular events initiated by exposure to blood-borne factors resulting sustained is not fully understood. We previously that astrocytes respond atypically mTBI,...
Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. dentate gyrus—a structure that is highly susceptible to injury—has been implicated in evolution of seizure development. Methods: Utilizing murine unilateral focal control cortical impact (CCI) injury, we evaluated onset using 24/7 EEG video analysis at 2–4 months post-injury....
Traumatic brain injury (TBI) can lead to post-traumatic epilepsy (PTE). Blast TBI (bTBI) found in Veterans presents with several complications, including cognitive and behavioral disturbances PTE; however, the underlying mechanisms that drive long-term sequelae are not well understood. Using an unbiased proteomics approach a mouse model of repeated bTBI (rbTBI), this study addresses gap knowledge. After rbTBI, mice were monitored using continuous, uninterrupted video-EEG for up four months....
Traumatic brain injury (TBI) is a leading cause of acquired epilepsy. TBI can result in focal or diffuse injury. Focal direct mechanical forces, sometimes penetrating through the cranium, creating lesion tissue. These are visible during imaging as areas with contusion, laceration, and hemorrhage. lesions induce neuronal death glial scar formation present 20%−25% all people who incur TBI. However, majority cases, caused by acceleration-deceleration forces subsequent tissue shearing, resulting...
Abstract Epilepsy is a chronic neurological disease, characterized by spontaneous, unprovoked, recurrent seizures that may lead to long-term disability and premature death. Despite significant efforts made improve epilepsy detection clinically pre-clinically, the pervasive presence of noise in EEG signals continues pose substantial challenges their effective application. In addition, discriminant features for have not been investigated yet. The objective this study develop hybrid model from...
Traumatic brain injury (TBI) is a leading cause of acquired epilepsy. TBI can result in focal or diffuse injury. Focal direct mechanical forces, sometimes penetrating through the cranium, creating lesion tissue. These are visible during imaging as areas with contusion, laceration, and hemorrhage. lesions induce neuronal death glial scar formation present 20%−25% all people who incur TBI. However, majority cases, caused by acceleration-deceleration forces subsequent tissue shearing, resulting...
The cerebellum is a potent anti-epileptic target for deep brain stimulation in patients with drug-resistant epilepsy. effects of such stimulation, however, may also favor seizure activity. Our goal was to investigate the effect cerebellar electrical (ES) alone and combination drug diazepam (DIA) on outcome. We used rat model pentylenetetrazol kindling, which characterized by seizures followed deteriorations central benzodiazepine-GABAA (BDZ-GABAA) receptors. tested ES DIA (0.1 1.0 mg/kg)...
Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. dentate gyrus, structure highly susceptible to injury, and has been implicated in evolution of seizure development. Methods: Utilizing murine unilateral focal control cortical impact (CCI) we evaluated onset using 24/7 EEG video analysis at 2-4 months post-injury. Cellular changes...
Shandra, Oleksii; Winemiller, Alexander; Heithoff, Benjamin; Munoz-Ballester, Carmen; George, Kijana; Benko, Michael J; Zuidhoek, Ivan; Besser, Michelle; Curley, Dallece; Edwards, G. Franklin III; Mey, Anroux; Harrington, Alexys; Kitchen, Jeremy; Robel, Stefanie Author Information
We investigated the activity of humoral and cellular links immunity leukocyte functional stability indicators in rats with experimental contact dermatitis (ECD) under pharmacological correction by application deltaran melatonin. Chronic experiments were performed on model chrome-induced ECD. Complex was assessed using separate combined administrations The results have shown pronounced disturbances immunity, as well neutrophil lymphocyte ECD rats. Violations immune system corrected...
О.О. Шандра Вплив дельтарану та мелатоніну на стан імунної системи щурів за умов експериментального контактного дерматитуДосліджували активність гуморального і клітинного ланок імунітету, а також показників функціональної стабільності лейкоцитів у з експериментальним контактним дерматитом (ЕКД) в умовах комплексної фармакологічної корекції введенням мелатоніну.Дослідження проводили хронічного експерименту моделі хроміндукованого ЕКД.Для використали роздільні сумісні введення й...
Abstract Mild traumatic brain injury/ concussion (mTBI) account for 70-90% of all reported TBI cases and cause long lasting neurological consequences in 10 to 40% patients. Recent clinical studies revealed increased blood-brain barrier (BBB) permeability mTBI patients, which correlated with secondary damage after mTBI. However, the cascade cellular events initiated by exposure blood-borne factors resulting sustained are not fully resolved. We previously that astrocytes respond atypically...