A5043467478- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Immune cells in cancer
- interferon and immune responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Inflammasome and immune disorders
- Neurogenesis and neuroplasticity mechanisms
- Mosquito-borne diseases and control
- Apelin-related biomedical research
- Infectious Encephalopathies and Encephalitis
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Gut microbiota and health
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
Virginia Tech
2019-2025
While originally identified as an antiviral pathway, recent work has implicated cyclic GMP-AMP-synthase-Stimulator of Interferon Genes (cGAS-STING) signaling playing a critical role in the neuroinflammatory response to traumatic brain injury (TBI). STING activation results robust inflammatory characterized by production cytokines called interferons, well hundreds interferon stimulated genes (ISGs). Global knockout (KO) mice inhibiting this pathway display neuroprotection with evidence that...
Chronic neurologic deficits from traumatic brain injury (TBI) and subsequent infectious encephalitis are poorly characterized. Using TriNetX database we queried patients 18 years or older with a confirmed diagnosis of between 2016 2024. Patient cohorts included those TBI at least one month before (N = 1,038), anytime 1,886), but no TBI, 45,210; N 45,215). A murine model controlled cortical impact (CCI) Venezuelan equine virus (VEEV) infection was used to reflect the clinical model, followed...
Dysregulation of lipid homeostasis is associated with a wide range pathologies encompassing neurological, metabolic, cardiovascular, oncological, and renal disorders. We previously showed that droplet (LD) accumulation in podocytes contributes to the progression diabetic kidney disease (DKD) reducing LDs preserves podocyte function prevents albuminuria. Here, we sought identify compounds treat pathological LD accumulation. developed phenotypic assay using human deployed it screen...
INTRODUCTION: It is known that traumatic brain injury (TBI) predisposes patients to chronic immune-susceptibility. However, neurologic deficits and key pathways associated with post-traumatic infections, such as encephalitis, are poorly characterized. METHODS: The TriNetX database was queried for all 18 years or older a confirmed diagnosis of encephalitis between 2016 2024. Patient cohorts included those TBI at least one month before (N = 1,038), anytime 1,886), but no TBI, which constituted...
Background: Traumatic brain injury (TBI) remains a significant risk factor for post-traumatic epilepsy (PTE). The pathophysiological mechanisms underlying the injury-induced epileptogenesis are under investigation. dentate gyrus—a structure that is highly susceptible to injury—has been implicated in evolution of seizure development. Methods: Utilizing murine unilateral focal control cortical impact (CCI) injury, we evaluated onset using 24/7 EEG video analysis at 2–4 months post-injury....
Circulating monocytes have emerged as key regulators of the neuroinflammatory milieu in a number neuropathological disorders. Ephrin type A receptor 4 (Epha4) tyrosine kinase, prominent axon guidance molecule, has recently been implicated regulation neuroinflammation. Using mouse model brain injury and GFP BM chimeric approach, we found neuroprotection lack significant motor deficits marked by reduced monocyte/macrophage cortical infiltration an increased arginase-1+ cells absence BM-derived...
Erythropoietin-producing human hepatocellular receptors play a major role in central nervous system injury. Preclinical and clinical studies revealed the upregulation of erythropoietin-producing A4 (EphA4) brain after acute traumatic We have previously reported that Cx3cr1-expressing cells peri-lesion show high levels EphA4 induction controlled cortical impact (CCI) injury mice. Cx3cr1 is fractalkine receptor expressed on both resident microglia peripheral-derived macrophages. The current...
Abstract Brain injury resulting from repeated mild traumatic insult is associated with cognitive dysfunction and other chronic co-morbidities. The current study tested the effects of aberrant neurogenesis in a mouse model brain (rmTBI). Using Barnes Maze analysis, we found significant reduction spatial learning memory at 24 days post-rmTBI compared to sham (rSham) injury. Cell fate analysis showed greater number BrdU-labeled cells which co-expressed Prox-1 DG rmTBI-injured mice coincided...
Monocyte/macrophages represent key cellular elements that contribute to acute tissue damage in the brain. Strategies aimed at their sequestration have revealed critical insight into injury response warrants further investigation. We show combining pre-depletion of circulating blood monocytes with murine brain injury, augmented release CD115+/Ly6Chi monocytes. This correlated and blood-brain barrier protection as well improved cerebral flow. reveal this shift resulted a reduced population...