A5048533541- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Tryptophan and brain disorders
- Immune cells in cancer
- Nitric Oxide and Endothelin Effects
- Nerve injury and regeneration
- Cardiovascular Syncope and Autonomic Disorders
- Phagocytosis and Immune Regulation
- Inflammatory mediators and NSAID effects
- Iron oxide chemistry and applications
- Eicosanoids and Hypertension Pharmacology
- Electroconvulsive Therapy Studies
- Neuroendocrine regulation and behavior
- Sports Performance and Training
- Pharmacological Receptor Mechanisms and Effects
- Radioactive element chemistry and processing
- Cardiovascular and exercise physiology
- Genetics and Neurodevelopmental Disorders
- Cellular Mechanics and Interactions
- Analytical Methods in Pharmaceuticals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- 3D Printing in Biomedical Research
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Neuropeptides and Animal Physiology
Argonne National Laboratory
2023
Argonne Leadership Computing Facility
2023
Virginia Tech
2019-2022
Biomedical Research Institute
2019
Arizona State University
2015
University College Hospital
1979-1981
University College London
1979-1981
Brain-derived neurotrophic factor (BDNF) is a critical growth involved in the maturation of CNS, including neuronal morphology and synapse refinement. Herein, we demonstrate astrocytes express high levels BDNF's receptor, TrkB (in top 20 protein-coding transcripts), with nearly exclusive expression truncated isoform, TrkB.T1, which peaks during astrocyte morphological maturation. Using novel culture paradigm, show that complexity increased presence BDNF dependent upon BDNF/TrkB.T1 signaling....
Circulating monocytes have emerged as key regulators of the neuroinflammatory milieu in a number neuropathological disorders. Ephrin type A receptor 4 (Epha4) tyrosine kinase, prominent axon guidance molecule, has recently been implicated regulation neuroinflammation. Using mouse model brain injury and GFP BM chimeric approach, we found neuroprotection lack significant motor deficits marked by reduced monocyte/macrophage cortical infiltration an increased arginase-1+ cells absence BM-derived...
1 Thirty-two hypertensive patients have been treated with labetalol for periods of up to 7 years. 2 Ten observed 6 years from time stabilization dosage, did not show any tolerance labetalol. 3 Postural and exercise hypotension were seen in these over this prolonged follow-up, although they other given g daily.
Two studies were carried out in the same six normal healthy males to compare circulatory effects of exogenously infused noradrenaline and adrenaline before after intravenous labetalol. 2Noradrenaline labetalol produced a similar pattern change, namely dose related systolic diastolic pressor responses accompanied by profound bradycardia reduced cardiac output. 3Labetalol competitively antagonized both noradrenaline. 4 Adrenaline at low doses depressor response increases heart rate output.The...
Early life stress interacts with adult to differentially modulate neural systems and vulnerability various psychiatric illnesses. However, the effects of early on addictive behaviors have not been sufficiently investigated. We examined in form prolonged maternal separation, followed adulthood by either 10 days chronic variable or no stress, methamphetamine self-administration, extinction, cue-induced reinstatement. observed that reduced self-administration rats a history stress. These...
Here, a 3D printed multiplexed competitive migration assay is reported for characterizing chemotactic response in the presence of multiple spatially distributed chemoattractants. The utility demonstrated by examining human glioblastoma cells to opposing gradients epidermal growth factor (EGF) and bradykinin (BK). Competitive assays involving EGF BK that are optimized absence second chemoattractant show 46% more migrate toward sources. velocities sources reduced 7.6 ± 2.2% 11.6 6.3% relative...
Abstract Brain derived neurotrophic factor (BDNF) is a critical growth involved in the maturation of neurons, including neuronal morphology and synapse refinement. Herein, we demonstrate astrocytes express high levels BDNF’s receptor, TrkB (in top 20 protein-coding transcripts), with nearly exclusive expression truncated isoform, TrkB.T1 which peaks during astrocyte morphological maturation. Using novel culture paradigm, show that complexity increased presence BDNF dependent upon...