A5007064983- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Cancer-related molecular mechanisms research
- HIV/AIDS drug development and treatment
- Immune cells in cancer
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heme Oxygenase-1 and Carbon Monoxide
- Sesquiterpenes and Asteraceae Studies
- RNA Interference and Gene Delivery
- HIV, Drug Use, Sexual Risk
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Bioactive Compounds and Antitumor Agents
- Erythrocyte Function and Pathophysiology
- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Cytokine Signaling Pathways and Interactions
Qingdao University
2025
Qingdao Municipal Hospital
2025
Second Affiliated Hospital of Jilin University
2015-2024
Nanjing Medical University
2018-2024
Wuxi People's Hospital
2018-2024
Southeast University
2016-2022
Chinese PLA General Hospital
2021
Yan'an University
2021
Yanan University Affiliated Hospital
2021
Weatherford College
2020
<h3>Background</h3> Tumor-associated macrophages (TAMs) facilitate tumor progression via establishment of an immunosuppressive microenvironment (TME). However, it is poorly understood how cells could functionally modulate TAMs. Our previous work indicated that cell-released autophagosomes (TRAPs), a type LC3-II<sup>+</sup> double-membrane extracellular vesicles (EVs) was sufficient to suppress anti-tumor immune responses by inducing IL-10-producing B and suppressive neutrophils. Here, we...
Abstract Glioblastoma multiforme (GBM) is the most malignant and aggressive primary brain tumor in adults. Despite concerted efforts to improve current therapies, prognosis of glioblastoma remains very poor. Alantolactone, a sesquiterpene lactone compound, has been reported exhibit antifungal, antibacteria, antihelminthic, anticancer properties. In this study, we found that alantolactone effectively inhibits growth triggers apoptosis cells time‐ dose‐dependent manner. The...
Excessive inflammation is a major cause of organ damage during sepsis. The elderly are highly susceptible to sepsis-induced injury. Sirt1 expression reduced aging. In the present study, we investigated role Sirt1, histone deacetylase, in controlling inflammatory responses murine sepsis model induced by cecal ligation and puncture (CLP). We examined lung signaling inducible knockout (Sirt1 −/− ) mice wild-type littermates +/+ after CLP. Our results demonstrated that deficiency led severe To...
Cisplatin [cis-diamminedichloroplatinum II (CDDP)] is one of the most classical and effective chemotherapeutic drugs for treatment cancers including lung cancer. However, presence cisplatin resistance in cancer lowers its curative effect limits usage clinic. The aim present study was to investigate underlying mechanisms involving endoplasmic reticulum (ER) stress autophagy. In study, we detected on cell viability, ER autophagy lines A549 H460. We also tested effects apoptosis induced by...
To estimate the nationwide and regional distribution of HIV-1 genotypes in China past three decades, province-specific molecular epidemiology data were derived from 260 independent studies HIV prevalence through searching PubMed, VIP Chinese Journal Database (VIP), National Knowledge Infrastructure, Wanfang Data January 1981 to December 2015. The was estimated by weighting genotype each province- risk-specific subpopulation with number reported cases corresponding subgroups relevant periods....
Abstract The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance apoptotic cells, also known as efferocytosis, is an immunologically silent process, thus maintaining immunosuppressive microenvironment (TME). Here we report that, in the breast microenvironment, thymosin α-1 (Tα-1) significantly reverses M2 polarization IL10-producing tumor-associated macrophages (TAM) during efferocytosis induced...
Isoalantolactone, a sesquiterpene lactone compound possesses antifungal, antibacteria, antihelminthic and antiproliferative activities.In the present study, we found that isoalantolactone inhibits growth induces apoptosis in pancreatic cancer cells.Further mechanistic studies revealed induction of is associated with increased generation reactive oxygen species, cardiolipin oxidation, reduced mitochondrial membrane potential, release cytochrome c cell cycle arrest at S phase.N-Acetyl Cysteine...
The regulative effects of microRNAs (miRNAs) on responses Schwann cells to a nerve injury stimulus are not yet clear. In this study, we noted that the expression 8 miRNAs was downregulated at different time points following rat sciatic transection, and found 368 potential targets were mainly involved in phenotypic modulation cells. Out miRNAs, miR-9 identified as an important functional regulator cell migration represented critical regenerative response injury. vitro, upregulated inhibited...
Abstract Background Airway remodeling is a poorly reversible feature of asthma which lacks effective therapeutic interventions. CD147 can regulate extracellular matrix (ECM) and tissue fibrosis, participate in the pathogenesis asthma. In this study, role airway activation circulating fibrocytes was investigated asthmatic mice. Methods Asthmatic mouse model established by sensitizing challenging mice with ovalbumin (OVA), treated anti-CD147 or Isotype antibody. The number eosinophils...
<h3>Background</h3> CD4<sup>+</sup> T cells are critical effectors of anti-tumor immunity, but how tumor influence cell effector function is not fully understood. Tumor cell-released autophagosomes (TRAPs) being recognized as modulators host immunity during progression. Here, we explored the mechanistic aspects TRAPs in modulation microenvironment. <h3>Methods</h3> isolated from lines and pleural effusions or ascites cancer patients were incubated with to examine mechanism differentiation...
LncRNA H19 is involved in the development of multiple cancers. Here, we firstly provide new evidence that can induce LIN28B, a conserved RNA binding protein, to accelerate lung cancer growth through sponging miR-196b. Abundance LIN28B was observed clinical samples. A positive link between and In cells, capable increasing expression. Mechanistically, miR-196b directly targeted inhibit promoting expression sequestering Functionally, H19-increased conferred cell proliferation cancer. Our...
Maternal allergic disease history and impaired regulatory T-cells (Tregs) are critical risk factors for allergy development in children. However, the mechanisms that underlie these remain poorly defined. Therefore, aim of this study was to assess whether maternal allergies affect Tregs offspring lead childhood.A total 332 mothers healthy newborns (234 from no mothers, 98 mothers) were recruited study. Detailed questionnaires administered yearly determine status birth 3 years age. Cord blood...
Most breast cancer-related deaths are caused by metastasis in vital organs including the lungs. Development of supportive metastatic microenvironments, referred to as premetastatic niches (PMNs), certain distant before arrival cells, is critical metastasis. However, mechanisms PMN formation not fully clear. Here, we demonstrated that chemoattractant C-C motif chemokine ligand 2 (CCL2) could be stimulated heat shock protein 60 (HSP60) on surface murine 4 T1 cancer cell-released LC3+...
Lung cancer is a type of malignant tumor with high morbidity and mortality. Due to its complicated etiology clinical manifestations, no significant therapeutic advance has been made. squamous cell carcinoma (LSCC) the most common lung cancer. To combat this disease, novel targets are badly requirement. ASPM (Abnormal spindle-like microcephaly-associated protein) involved in multiple cellular or developmental processes, such as neurogenesis brain growth. also reported widely expressed tissues...
Our previous studies have confirmed that tumor cell-released autophagosomes (TRAP) could induce the differentiation of B cells into IL-10+ regulatory (Bregs) with suppressive activities on T lymphocytes. However, mechanism TRAP-mediated immune suppression is still largely unclear. Herein, we sought to assess immunomodulatory effect TRAPs human neutrophils, a major cell type infiltrates tissues. We found enriched from malignant effusions or ascites cancer patients and lines were rapidly...
Objectives The epidemic of HIV-1 CRF01_AE has become a major public health issue in China. This study aimed to characterise the transmission patterns genetic networks for nationwide and elucidate possible opportunities prevention. Methods We isolated conducted network analysis all available pol sequences (n=4704) from China Los Alamos HIV sequence database. Results A total 1391 (29.6%) were identified as belonging 400 separate networks. Of men who have sex with (MSM) networks, 93.8% linked...
No systemic evaluation of asthma control in Jilin Province has been reported. Asthma might provide the basis for management this region. A multicenter hospital-based cross-sectional study was performed to investigate and related factors severe exacerbations patients with moderate or Province, China. The enrolled 1546 five grade one general hospitals from January December 2013. medication, patient self-management, test (ACT) scores frequency during follow-up (12 months) were collected via a...
A simple and effective strategy was developed to enrich ubiquitinated proteins (UPs) from cancer cell lysate using the α-Al2O3 nanoparticles covalently linked with ubiquitin binding protein (Vx3) (denoted as α-Al2O3–Vx3) via a chemical linker. The functionalized α-Al2O3–Vx3 showed long-term stability high efficiency for enrichment of UPs lysates. Flow cytometry analysis results indicated dendritic cells (DCs) could more effectively phagocytize α-Al2O3–Vx3-UPs than physical mixture Vx3-UPs...
To characterize the current frequency of HIV-1 coreceptor usage in China and assess candidacy CCR5 antagonists for treatment HIV infections. In addition, we aimed to evaluate potential X4/DM virus transmission recently infected men who have sex with (MSM) individuals. Viral tropism testing was performed on samples from 399 MSM individuals 2408 available Chinese V3 sequences downloaded Los Alamos database using Geno2pheno WebPSSM combination. The clusters were evaluated pol 291 a maximum...