A5081712902- Immune cells in cancer
- Cellular Mechanics and Interactions
- Single-cell and spatial transcriptomics
- Erythrocyte Function and Pathophysiology
- Advanced Fiber Laser Technologies
- MicroRNA in disease regulation
- Cell Image Analysis Techniques
- Acute Ischemic Stroke Management
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- Diabetic Foot Ulcer Assessment and Management
- Nonlinear Photonic Systems
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Natural Compounds in Disease Treatment
- Mathematical Analysis and Transform Methods
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Ferrocene Chemistry and Applications
- Nutrition and Health in Aging
- Nonlinear Waves and Solitons
- Histone Deacetylase Inhibitors Research
- Berberine and alkaloids research
- Intracerebral and Subarachnoid Hemorrhage Research
Southeast University
1995-2024
Shanghai University
2024
Zhongda Hospital Southeast University
2024
Ningbo University
2023-2024
Guangdong University of Technology
2023
Shenzhen University
2023
Ningbo No.6 Hospital
2022
Ningbo First Hospital
2021
Second Affiliated Hospital of Zhejiang University
2019
Neurological Surgery
2019
Abstract The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance apoptotic cells, also known as efferocytosis, is an immunologically silent process, thus maintaining immunosuppressive microenvironment (TME). Here we report that, in the breast microenvironment, thymosin α-1 (Tα-1) significantly reverses M2 polarization IL10-producing tumor-associated macrophages (TAM) during efferocytosis induced...
Background Lung metastasis is the primary cause of breast cancer-related mortality. Neutrophil extracellular traps (NETs) are involved in progression cancer. However, mechanism NET formation not fully understood. This study posits that tumor cell-released autophagosomes (TRAPs) play a crucial role this process. Methods TRAPs were isolated from cancer cell lines to analyze their impact on both human and mouse neutrophils. The used vitro vivo models, including Toll-like receptor 4 (TLR4 − / )...
Most breast cancer-related deaths are caused by metastasis in vital organs including the lungs. Development of supportive metastatic microenvironments, referred to as premetastatic niches (PMNs), certain distant before arrival cells, is critical metastasis. However, mechanisms PMN formation not fully clear. Here, we demonstrated that chemoattractant C-C motif chemokine ligand 2 (CCL2) could be stimulated heat shock protein 60 (HSP60) on surface murine 4 T1 cancer cell-released LC3+...
Abstract This study aims to identify predictive factors related clinical outcome, reoperation, and complications in patients with brain abscess. Patients a diagnosis of abscess at discharge the Second Affiliated Hospital Zhejiang University School Medicine between 2008 2018 were reviewed. Logistic regression was used associated Glasgow Outcome Scale (GOS) discharge, GOS 1 year after reoperation complications. Among 183 enrolled into study, 142 had good outcome (GOS ≥ 4) 41 poor ≤ 3). During...
Abstract Tumor cell-released LC3 + extracellular vesicles (LC3 EVs) participate in immunosuppression during autophagy and contribute to the occurrence development of breast cancer. In view strong association between EVs cancer, developing an effective strategy for quantitative detection levels with high sensitivity identify as new biomarkers accurate diagnosis cancer is crucial, but yet not been reported. Herein, ultrasensitive electrochemical immunosensor presented determination using a...
The role of hyperbaric oxygen therapy (HBOT) in the treatment acute ischemic stroke is controversial. This study aims to investigate whether peripheral insulin sensitivity type 2 diabetes patients suffering from intracerebral hemorrhage can be increased after HBOT.Fifty-two participants were recruited being diagnosed with our hospital. Insulin was measured by glucose infusion rate during a hyperinsulinemic euglycemic clamp (80 mU m-2 min-1) at baseline and 10 30 days HBOT sessions. Serum...
We have previously identified ubiquitinated proteins (UPs) from tumor cell lysates as a promising vaccine for cancer immunotherapy in different mouse models. In this study, we aimed at developing highly efficient therapeutic adjuvant built-in nanovaccine (α-Al2O3-UPs) by simple method, which UPs cells could be efficiently and conveniently enriched α-Al2O3 nanoparticles covalently coupled with Vx3 (α-Al2O3-CONH-Vx3).The were modified 4-hydroxybenzoic acid followed coupling ubiquitin-binding...
Spinal cord malignant melanotic schwannoma (MMNST) is a rare central nervous system tumor that originates from the spinal or myelin sheath cells and can produce melanin. This type of usually highly aggressive malignant, with poor prognosis. The clinical manifestations MMNST are mainly pain, paresthesia, muscle weakness, atrophy, etc., symptoms compression, such as intestinal bladder dysfunction, paraplegia, etc. Early detection lesions facilitate removal, improve patients' quality life,...
We previously reported that enriched ubiquitinated proteins (UPs) from tumor cells have the potential to be used as immunotherapy vaccine against cancer. Here we UPs epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cell line (4T1/EPB) and tested efficacy of α-Al 2 O 3 -UPs-4T1/EPB (short for UPs-4T1/EPB) therapeutic alone in combination with stimulator interferon genes (STING) agonist mice drug-resistant metastatic Vaccination UPs-4T1/EPB exerted profound anti-tumor...
<div>Abstract<p>The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance apoptotic cells, also known as efferocytosis, is an immunologically silent process, thus maintaining immunosuppressive microenvironment (TME). Here we report that, in the breast microenvironment, thymosin α-1 (Tα-1) significantly reverses M2 polarization IL10-producing tumor-associated macrophages (TAM) during...
Supplementary Figure from Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis
Supplementary Figure from Thymosin α-1 Reverses M2 Polarization of Tumor-Associated Macrophages during Efferocytosis
This paper proposes the concept of rotated quaternion valued algebra and its application to human signal processing. The conventional number consists three pure imaginary components. They are i component, j component k component. These components can be understood as these standard principal axes in Cartesian coordinate, which they orthogonal one another. In this paper, via multiplying rotational matrices. Here, matrices perform rotations with respect axes, respectively. Now, discrete time...
At present, an all optical high-order tunable ordinary differential equation (ODE) solver is very difficult to implement. A novel all-optical first third order linear ODEs solutions with constant coefficients using double Sagnac rings coupled Mach–Zehnder-interferometer (DSMZI) on silicon waveguide chips are proposed. The structural composition and size of the DSMZI have been designed, working principles its derived. By varying input electric heating power thermal-optical phase shifters...
<div>Abstract<p>The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance apoptotic cells, also known as efferocytosis, is an immunologically silent process, thus maintaining immunosuppressive microenvironment (TME). Here we report that, in the breast microenvironment, thymosin α-1 (Tα-1) significantly reverses M2 polarization IL10-producing tumor-associated macrophages (TAM) during...