A5055529062- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Reproductive Physiology in Livestock
- Urticaria and Related Conditions
- Bladder and Urothelial Cancer Treatments
- Urologic and reproductive health conditions
- Psoriasis: Treatment and Pathogenesis
- Urological Disorders and Treatments
- Food Allergy and Anaphylaxis Research
- Endoplasmic Reticulum Stress and Disease
- Urinary and Genital Oncology Studies
- Per- and polyfluoroalkyl substances research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Blood Coagulation and Thrombosis Mechanisms
Southwest Hospital
2025
Army Medical University
2025
Ningbo University
2023-2024
Ningbo First Hospital
2024
Jinan University
2023
Shantou University
2008-2022
Shantou University Medical College
2008-2022
Aquatic Systems (United States)
2014
Innovation Performance (Norway)
2014
Fatty acid oxidation (FAO) fuels many cancers. However, knowledge of pathways that drive FAO in cancer remains unclear. Here, we revealed valosin-containing protein (VCP) upregulates to promote colorectal growth. Mechanistically, nuclear VCP binds histone deacetylase 1 (HDAC1) and facilitates its degradation, thus promoting the transcription genes, including rate-limiting enzyme carnitine palmitoyltransferase 1A ( CPT1A ). is an alternative fuel for cells environments exhibiting limited...
Abstract Background: Generalized pustular psoriasis (GPP), a rare and recurrent autoinflammatory disease, imposes substantial burden on patients society. Awareness of GPP in China remains limited. Methods: This cross-sectional survey, conducted between September 2021 May 2023 across 14 hospitals China, included all ages disease phases. Data collected encompassed demographics, clinical characteristics, economic impact, severity, quality life, treatment-related complications. Risk factors for...
Enniatin B1 (ENN B1) is a mycotoxin that can be found in various foods. However, whether ENN hazardous to the reproductive system still elusive. Leydig cells are testosterone-generating reside interstitial compartment between seminiferous tubules. Dysfunction of could result male infertility. This study aimed examine toxicological effects against TM3 cells. significantly inhibited cell viability dose-dependent manner. treatment also decreased expression functional genes Moreover, induced...
Abstract Glioblastoma (GBM) is the deadliest form of brain cancer. It a highly angiogenic and immunosuppressive malignancy. Although immune checkpoint blockade therapies have revolutionized treatment for many types cancer, their therapeutic efficacy in GBM has been far less than expected or even ineffective. In this study, we found that genomic signature glioma-derived endothelial cells (GdEC) correlates with an state poor prognosis patients glioma. We established vitro model GdEC...
Immune checkpoint blockade therapies are still ineffective for most patients with colorectal cancer (CRC). Immunogenic cell death (ICD) enables the release of key immunostimulatory signals to drive efficient anti-tumor immunity, which could be used potentiate effects immune inhibitors. Here, we showed that inhibition valosin-containing protein (VCP) elicits ICD in CRC. Meanwhile, VCP inhibitor upregulates PD-L1 expression and compromises immunity vivo. Mechanistically, transcriptionally...
Summary Background The cockroach is a major source of indoor allergens, which cause perennial rhinitis and asthma. Per 7 one the allergens from American cockroach, eliciting IgE reaction in over 50% sera allergic individuals. However, actions pathogenesis diseases remain poorly understood. Objective aim study was to investigate effects on expression protease‐activated receptors (PARs) murine mast cells release T‐helper type 2 (Th2) cytokines these cells. Methods gene cloned expressed...
<div>Abstract<p>Glioblastoma (GBM) is the deadliest form of brain cancer, characterized as a highly angiogenetic and immunosuppressive malignancy. Although immune checkpoint blockades have revolutionized cancer therapy, their therapeutic efficacy in GBM has been far less than expected or even ineffective. Here, we reveal that genomic signature glioma-derived endothelial cells (GdECs) correlates with an state poor prognosis glioma patients. In vitro model GdECs differentiation...
<p>Supplementary Figure 1-12</p>
<p>Supplementary Figure 1-12</p>
<p>Supplementary Figure 1-12</p>
<div>Abstract<p>Glioblastoma (GBM) is the deadliest form of brain cancer. It a highly angiogenic and immunosuppressive malignancy. Although immune checkpoint blockade therapies have revolutionized treatment for many types cancer, their therapeutic efficacy in GBM has been far less than expected or even ineffective. In this study, we found that genomic signature glioma-derived endothelial cells (GdEC) correlates with an state poor prognosis patients glioma. We established...
<div>Abstract<p>Glioblastoma (GBM) is the deadliest form of brain cancer. It a highly angiogenic and immunosuppressive malignancy. Although immune checkpoint blockade therapies have revolutionized treatment for many types cancer, their therapeutic efficacy in GBM has been far less than expected or even ineffective. In this study, we found that genomic signature glioma-derived endothelial cells (GdEC) correlates with an state poor prognosis patients glioma. We established...
<p>Supplementary Figure 1-12</p>
dimensional reconstruction seen from the underside of human epidermis, generated immunohistochemistry whole skin biopsy samples obtained at 7 days after wounding.Cyan represents pilosebaceous units; magenta, eccrine sweat glands; yellow, new epidermis; gray, mesh for contours.