A5067669880- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- RNA regulation and disease
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- melanin and skin pigmentation
- Genetic and rare skin diseases.
- Urticaria and Related Conditions
- Acne and Rosacea Treatments and Effects
- Drug-Induced Adverse Reactions
- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Dermatological and COVID-19 studies
- Telomeres, Telomerase, and Senescence
- Wound Healing and Treatments
- Retinoids in leukemia and cellular processes
- Tissue Engineering and Regenerative Medicine
- Sarcoidosis and Beryllium Toxicity Research
- Tumors and Oncological Cases
- Tuberculosis Research and Epidemiology
- Blood disorders and treatments
- FOXO transcription factor regulation
- Pharmacovigilance and Adverse Drug Reactions
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
Beijing Children’s Hospital
2022-2025
Capital Medical University
2022-2025
Ministry of Education of the People's Republic of China
2024-2025
China-Japan Friendship Hospital
2017-2019
Peking University
2018-2019
Abstract Background: Generalized pustular psoriasis (GPP), a rare and recurrent autoinflammatory disease, imposes substantial burden on patients society. Awareness of GPP in China remains limited. Methods: This cross-sectional survey, conducted between September 2021 May 2023 across 14 hospitals China, included all ages disease phases. Data collected encompassed demographics, clinical characteristics, economic impact, severity, quality life, treatment-related complications. Risk factors for...
To evaluate the outcomes of secukinumab and acitretin use in children with generalized pustular psoriasis (GPP), we compared efficacy adverse events 20 16 GPP from January 1, 2019, to 30, 2022. Among patients treated secukinumab, average time for pustules fade, temperature normalize, C-reactive protein (CRP) normalize was 3.83, 2.46, 3.91 days, respectively. All recovered (Japanese Dermatological Association severity index score: 0/1) 3 weeks. The were abnormal liver enzyme (10%), atopic...
The aim of this study was to conduct a more comprehensive analysis the association between psoriasis and abnormal lipid metabolism.The case-control included 222 psoriatic patients 445 non-psoriatic control matched for age gender. Clinical parameters age, gender, body mass index (BMI). Serum levels were recorded cholesterol (CHO), triglycerides (TG), low-density lipoprotein (LDL), high density (HDL), phospholipids (PLIP), free fatty acids (FFA), (a) [Lp(a)], apolipoproteins (apoA1, apoB,...
Generalized pustular psoriasis (GPP) is a severe inflammatory cutaneous disease characterized by widespread pustules, edema, erythema, fever, and systemic inflammation. Chinese data indicate that the prevalence incidence of GPP follow bimodal age distribution, with peaks in 0–3 year group 30–39 group.1 In group, was 0.927 rate 0.742 per 100 000 population-years.1 Interleukin (IL)-36 plays an important role activating nuclear factor-κB (NF-κB) mitogen-activated protein kinase (MAPK) signal...
Background: Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening inflammatory cutaneous disease. IL-36 key treatment target in GPP. Spesolimab, humanized monoclonal antibody of the receptor, has demonstrated good efficacy favorable safety profile adults with However, data on its use children are scarce. Methods: We treated patients aged 4– 12 years GPP single dose spesolimab. The Pustular Psoriasis Physician Global Assessment (GPPGA) total score, GPPGA...
Generalized pustular psoriasis (GPP) is a rare and life-threatening autoinflammatory dermatological disease. IL36RN was reported to be the main pathogenetic basis for GPP. Only few studies have on correlation analysis of variants phenotype pediatric-onset GPP.IL36RN screened in 60 children diagnosed with GPP from January 2013 2020, their detailed clinical profiles were obtained.Forty-six out (76.67%) patients harbored variants, six found, which two novel that first time. The frequency...
Abstract We report a case of 30‐year‐old Chinese woman with rheumatoid arthritis and interstitial lung disease who abruptly developed generalized pustules high fever for 10 days. She had been taking oral prednisone, iguratimod total glucosides peony regularly 5 months prior. In addition, she taken metronidazole 3 days 20 prior which used before no adverse reaction. history similar lesions psoriasis. A biopsy pustule on the back showed spongiform Kogoj. was suspected having pustular psoriasis...
To the editor: We report case of a 14-year-old boy who presented with some painful, confluent, and erythematous vesicles on left lumbosacral side, 2-day history fever, severe headache, fatigue (Figure 1A). There were no convulsions, abdominal pain, or diarrhea. Over next 5 days, skin lesions progressed to scattered throughout face, trunk, extremities, oral mucosa 1B). The had medical juvenile rheumatoid arthritis for 7 years was taking prednisone thalidomide. He experienced chicken pox...
Objective To report two cases of blastic plasmacytoid dendritic cell neoplasm(BPDCN). Methods The clinical and histopathological manifestation, immunophenotype, treatment prognosis BPDCN were analyzed in patients. Results Both the patients female with skin lesions as initial manifestation. Case 1 presented purple nodules on waist, back left upper limb; examination revealed that a large number lymphoid cells diffusely infiltrated dermis subcutaneous fat layer, an uninvolved zone...