A5091308565- Antibiotic Resistance in Bacteria
- COVID-19 and Mental Health
- Poxvirus research and outbreaks
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- COVID-19 Pandemic Impacts
- RNA Interference and Gene Delivery
- Bacillus and Francisella bacterial research
- Mangiferin and Mango Extracts
- Natural Antidiabetic Agents Studies
- Traditional and Medicinal Uses of Annonaceae
- SARS-CoV-2 and COVID-19 Research
- Enzyme-mediated dye degradation
- Cavitation Phenomena in Pumps
- Image Processing Techniques and Applications
- Water Treatment and Disinfection
- COVID-19 Prevention and Impact
- Phenothiazines and Benzothiazines Synthesis and Activities
- Hydrogen Storage and Materials
- Oral and Maxillofacial Pathology
- Bacterial biofilms and quorum sensing
- Heat Transfer Mechanisms
- Phytochemicals and Antioxidant Activities
- bioluminescence and chemiluminescence research
- Animal Virus Infections Studies
University of Oklahoma
2021-2025
Jahangirnagar University
2023-2024
Dhaka University of Engineering & Technology
2019
While the world is still attempting to recover from damage caused by broad spread of COVID-19, Monkeypox virus poses a new threat becoming global pandemic. Although itself not deadly and contagious as every day, patients case has been reported many nations. Therefore, it will be no surprise if ever faces another pandemic due lack proper precautious steps. Recently, Machine learning (ML) demonstrated huge potential in image-based diagnoses such cancer detection, tumor cell identification,...
Tripartite resistance nodulation and cell division multidrug efflux pumps span the periplasm are major drivers of among gram-negative bacteria. Cations, such as Mg2+, become concentrated within and, in contrast to cytoplasm, its pH is sensitive conditions outside cell. Here, we reveal an interplay between Mg2+ modulating structural dynamics periplasmic adapter protein, AcrA, function prototypical AcrAB-TolC pump from Escherichia coli. In absence AcrA becomes increasingly plastic acidic...
The research aims to analyze the catabolic strength of different hydrolytic enzymes in assessing biological conversion potential lignocellulose parts agricultural biomass wastes into functional edible sugars and biofuels.
This paper explains the initial Monkeypox Open image data collection procedure. It was created by assembling images collected from websites, newspapers, and online portals currently contains around 1905 after augmentation.
Abstract Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite pump system from Escherichia coli , AcrAB-TolC, is target for inhibition to lessen resistance development and restore antibiotic efficacy, with homologs other ESKAPE pathogens. Here, we rationalize mechanism of against the periplasmic adaptor protein, AcrA, using combination hydrogen/deuterium exchange mass spectrometry, cellular assays, molecular dynamics simulations. We define structural AcrA...
Currently, liver diseases have become a serious global health issue, and this situation occurs due to the exposure of different agents, such as chemicals, alcohol, viruses, autoimmune diseases. Mangiferin is natural bioactive xanthone C-glycoside compound potent antioxidant that widely found in medicinal plants leaves Mangifera indica L. (Anacardiaceae). It possesses wide range biological properties, antidiabetic, hepatoprotective, anti-inflammatory, antioxidant, anticarcinogenic activities....
HIV continues to be a global public health issue. Urban slums in Bangladesh are at high risk for the epidemic, but little is known about how slum people perceive their and deal with alcohol use. Therefore, focus of study was explore perception, problematic use associated factors within urban settings. We conducted cross-sectional between March May 2023 among 739 residents Bangladesh. Data analysis involved bivariate multivariate linear regression analyses. The participants' mean age 29.7 (SD...
Bacterial efflux pumps provide resistance to antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, during nutrient starvation. The MdtEF pump from Escherichia coli is upregulated in these conditions forms part of the proton motive force-driven resistance-nodulation-cell division (RND) superfamily. Here, we report cryo-electron microscopy structures native lipid-contained multidrug exporter MdtF, including a single-point mutant with an...
Abstract Background Monkeypox virus (MPV), an endemic pathogen in Africa, shares clinical similarities with smallpox. Recent reports indicate a concerning increase the number of MPV cases detected outside its region, highlighting emergence multi-country outbreak. Given importance cell surface-binding protein E8L facilitating viral attachment to host cells, this study aimed identify potential small interfering RNAs (siRNAs) capable silencing and thereby serving as basis for therapeutic...
Antibiotic resistance poses an immediate and growing threat to human health. Multidrug efflux pumps are promising targets for overcoming antibiotic with small-molecule therapeutics. Previously, we identified a diaminoquinoline acrylamide, NSC-33353, as potent inhibitor of the AcrAB–TolC pump in Escherichia coli. This potentiates antibacterial activities novobiocin erythromycin upon binding membrane fusion protein AcrA. It is also substrate lacks appreciable intrinsic activity its own...
Tripartite resistance nodulation and cell division multidrug efflux pumps span the periplasm are a major driver of among Gram-negative bacteria. The provides distinct environment between inner outer membranes Cations, such as Mg
Optimization of compound permeation into Gram-negative bacteria is one the most challenging tasks in development antibacterial agents. Two permeability barriers─the passive diffusion barrier outer membrane (OM) and active drug efflux─act synergistically to protect cells from action compounds. In Escherichia coli (E. coli) relatives, these two barriers sieve compounds based on different physicochemical properties that are defined by their interactions with OM porins efflux pumps,...
Abstract Background Human health is largely affected by self-medication in both ways, adversely and favorably, as evidenced the COVID-19 pandemic. The fear of spreading among workers hospital environments has led many Bangladeshi people to practice self-medicate for a preventive strategy against this disease. Consequently, entails an improper injudicious use medicine cure self-recognized symptoms. To date, no effective treatment. lack continual progression diseases educational settings...
To study the antibacterial and phytochemical activities of bioactive elements in leaves Annona reticulata Linn, a historically used Bangladeshi medicinal plant.
The human immunodeficiency virus (HIV) mainly attacks CD4+ T cells in the host. Chronic HIV infection gradually depletes cell pool, compromising host’s immunological reaction to invasive infections and ultimately leading acquired syndrome (AIDS). goal of this study is not provide a qualitative description rich dynamic characteristics model cells, but produce accurate analytical solutions using modified iterative approach. In research, new efficient method (NIM), coupling standard NIM Laplace...
This research aimed to isolate, identify, and characterize a new strain of Bacillus cereus through different molecular biology approaches so that it could be further studied for therapeutic purposes against selective enteric pathogens.Pure isolates B. were prepared from buffalo yogurt samples in REMBA medium. Initially, the morphological, physiological, biochemical properties accordingly. Following tests, identification was conducted plasmid DNA extraction, PCR, agarose gel electrophoresis,...
Myxofibrosarcoma belongs to the group of sarcoma tumours, which represent only 1% adult tumours worldwide. It is one rare, aggressive connective tissue neoplasm malignant fibrocytes in a myxoid matrix, and mostly occurs people their 60s 80s. Like many other tissue, it reveals high recurrence rates, but rarely metastasise. We present case 50-year-old female who had large, soft over left leg. Wide surgical excision was done due its increased size clinical behaviour, so as increase patient's...
Background: Human health is largely affected by self-medication in both ways, adversely and favorably, as evidenced the COVID-19 pandemic. The fear of spreading novel coronavirus disease (COVID-19) from workers hospital environments has led many Bangladeshi people to practice self-medicate for preventive strategy against this disease. Consequently, entails an improper injudicious use medicine cure self-recognized symptoms. To date, no effective treatment. lack a continual progression...
Abstract Membrane efflux pumps play a major role in bacterial multidrug resistance. The tripartite pump system from Escherichia coli , AcrAB-TolC, is target for inhibition to lessen resistance development and restore antibiotic efficacy, with homologs other ESKAPE pathogens. Here, we rationalize mechanism of against the periplasmic adaptor protein, AcrA, using combination hydrogen/deuterium exchange mass spectrometry, cellular assays, molecular dynamics simulations. We define structural AcrA...
Background: Due to a lack of treatments and vaccinations, the COVID-19 pandemic has resulted in number mental disorders, which have led psychiatric symptoms pleasure with one's life students. Researchers found that perceived SWL MWB dropped, may be because students are more likely experience health problems. The present study investigated prevalence determinants well-being satisfaction among university Bangladesh. Methods: An e-survey-based cross-sectional was carried out from February April...
Abstract Background Luciferase is a well-known oxidative enzyme that produces bioluminescence. The Pseudomonas meliae plant pathogen causes wood rot on nectarine and peach possesses luciferase-like monooxygenase. After activation, it bioluminescence, the pathogen’s bioluminescence visual indicator of diseased plants. Methods present study aims to model characterize monooxygenase protein in P. for its similarity well-established luciferase. In this study, from infects chinaberry plants has...
After the first infection in December 2019, mutating strains of SARS-CoV2 have already affected a lot healthy people around world. But situations not been as devastating before pandemic omicron SARS-CoV2. As June 2022, two more Omicron offshoots, BA.4 and BA.5, are now proliferating worldwide. Perhaps there variants dormant that require only minor changes to resurrect. So, this study was conducted with view halting afterwards. In study, we looked at spike protein see if any potential siRNAs...