A5019868672- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Machine Learning in Bioinformatics
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- COVID-19 Clinical Research Studies
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Bacteriophages and microbial interactions
- Virology and Viral Diseases
- Clostridium difficile and Clostridium perfringens research
- Gene expression and cancer classification
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
- Genomics and Rare Diseases
- Natural Antidiabetic Agents Studies
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- interferon and immune responses
- Salmonella and Campylobacter epidemiology
- Biochemical and Molecular Research
- Mosquito-borne diseases and control
- Probiotics and Fermented Foods
- Phosphodiesterase function and regulation
National Institute of Biotechnology
2018-2025
Czech Academy of Sciences, Institute of Biotechnology
2020-2023
National Institute of Cardiovascular Diseases
2018-2023
University of Oxford
2021-2023
University of Science and Technology
2022
Sylhet Agricultural University
2022
University of Windsor
2022
Mawlana Bhashani Science and Technology University
2014-2021
University of Kentucky
2021
Ebola viruses (EBOVs) have been identified as an emerging threat in recent year it causes severe haemorrhagic fever human. Epitope-based vaccine design for EBOVs remains a top priority because mere progress has made this regard. Another reason is the lack of antiviral drug and licensed although there outbreak Central Africa. In study, we aimed to epitope-based that can trigger significant immune response well prognosticate inhibitor bind with potential target sites using various...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), is rapidly acquiring new mutations. Analysis these mutations necessary for gaining knowledge regarding different aspects therapeutic development. Previously, we have reported a Sanger method-based genome sequence viral isolate named SARS-CoV-2 NIB-1, circulating in Bangladesh. The has four novel non-synonymous V121D, V843F, A889V, and G1691C positions. Using computational...
GRIN2A is a gene that encodes NMDA receptors found in the central nervous system and plays pivotal role excitatory synaptic transmission, plasticity excitotoxicity mammalian system. Changes this have been associated with spectrum of neurodevelopmental disorders such as epilepsy. Previous studies on suggest non-synonymous single nucleotide polymorphisms (nsSNPs) can alter protein's structure function. To gain better understanding impact potentially deleterious variants GRIN2A, range...
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders which can affect quality life severely. Injectable insulin currently being used to treat DM mainly associated with patient inconvenience. Small molecules that act as receptor (IR) agonist would be better alternatives injection. Herein, ten bioactive small compounds derived from Gymnema sylvestre (G. sylvestre) were chosen determine their IR binding affinity and ADMET properties using a combined approach molecular docking...
Background:Shigella flexneri is a gram negative bacteria that causes the infectious disease "shigellosis." S. responsible for developing diarrhea, fever, and stomach cramps in human. Antibiotics are mostly given to patients infected with shigella. Resistance antibiotics can hinder its treatment significantly. Upon identification of essential therapeutic targets, vaccine drug could be effective therapy shigellosis. Methods: The study was designed qualitative characterization potential targets...
Genetic polymorphisms in DNA damage repair and tumor suppressor genes have been associated with increasing the risk of several types cancer. Analyses putative functional single nucleotide (SNP) such can greatly improve human health by guiding choice therapeutics. In this study, we selected nine responsible for various cancer gene enrichment analysis found that BRCA1, ATM, TP53 were more enriched connectivity. Therefore, used different computational algorithms to classify nonsynonymous SNPs...
Hendra henipavirus (HeV) is an emerging zoonotic bat-borne paramyxovirus that capable of causing severe public health complications in humans. It promotes both respiratory and neurological disorders humans as well horses. Currently, there are no therapeutics or vaccines available against the deadly HeV. We aimed to design a potent novel prophylactic chimeric vaccine HeV through immunoinformatics approach. A proteome-wide screening was performed identify antigenic proteins followed by...
As the COVID-19 pandemic continues to ravage across globe and take millions of lives like many parts world, second wave hit Bangladesh, this study aimed at understanding its causative agent, SARS-CoV-2 genomic proteomic level provide precious insights about pathogenesis, evolution, strengths weaknesses virus. Mid-June 2021, over 1500 genomesequences have been deposited in GISAID database from Bangladesh which were extracted categorized into two waves. By analyzing these genome sequences, it...
HMG-CoA reductase or HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) is a rate-limiting enzyme involved in cholesterol biosynthesis. plays an important role the possible occurrence of hypercholesterolemia leading to atherosclerosis and coronary heart disease. This major target for cholesterol-lowering drugs such as "statin" which blocks synthesis mevalonate, precursor study aimed at characterizing deleterious mutations classifying functional single nucleotide polymorphisms (SNPs) gene...
As an omnipresent opportunistic bacterium, Pseudomonas aeruginosa PAO1 is responsible for acute and chronic infection in immunocompromised individuals. Currently, this bacterium on WHO's red list where new antibiotics are urgently required the treatment. Finding essential genes hypothetical proteins (EHP) can be crucial identifying novel druggable targets therapeutics. This study aimed at characterizing these EHPs analyzing subcellular physiochemical properties, PPI network, nonhomologous...
Abstract Background Helicobacter pylori is a gastric pathogen that responsible for causing chronic inflammation and increasing the risk of cancer development. It capable persisting decades in harsh environment because inability host to eradicate infection. Several treatment strategies have been developed against this bacterium using different antibiotics. But effectiveness treating H. has significantly decreased due widespread antibiotic resistance, including an increased cancer. The small...
Streptomyces coelicolor is a gram-positive soil bacterium which well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, present study aimed to reveal functions protein S. coelicolor. Several bioinformatics tools were employed predict structure and function this protein. Sequence similarity was searched through available databases find out homologous The secondary...
An outbreak of West Nile Virus (WNV) like the recent Ebola can be more epidemic and fatal to public health throughout world. WNV possesses utmost threat as no vaccine or drug is currently available for its treatment except mosquito control. The current study applied combined approach immunoinformatics pharmacoinformatics design potential epitope-based vaccines candidates against WNV. By analyzing whole proteome 2994 proteins, envelope glycoprotein was selected a therapeutic target based on...
Coronavirus disease-2019 (COVID-19) is a recent world pandemic disease that caused by newly discovered strain of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2). Patients with comorbidities are most vulnerable to this disease. Therefore, cancer patients reported be more susceptible COVID-19 infection, particularly lung patients. To evaluate probable reasons behind excessive susceptibility and fatality we targeted two crucial agents, Angiotensin-converting enzyme 2 (ACE2)...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic emerged in 2019 and still requiring treatments with fast clinical translatability. Frequent occurrence of mutations spike glycoprotein SARS-CoV-2 led the consideration an alternative therapeutic target to combat ongoing pandemic. main protease (M pro ) is such attractive drug due its importance maturating several polyproteins during replication process. In present study, we used a classification structure–activity...
Breast cancer (BC) is the second most prevalent worldwide. Estrogen receptor beta (ERβ) an essential protein of breast cells to suppress estrogen-induced uncontrolled proliferation. Thus, small molecules that can modulate and enhance ERβ expression would be effective agent BC development. Studies showed cannabinoid (CB), specifically delta-9-tetrahydrocannabinol (Del9THC), increase inhibits cell In this study, less psychoactive structurally similar analogs Del9THC were chosen as drug...
Abstract Neurodegenerative diseases, such as Alzheimer’s disease, pose a significant global health challenge with their complex etiology and elusive biomarkers. In this study, we developed the Identification Tool (AITeQ) using ribonucleic acid-sequencing (RNA-seq), machine learning (ML) model based on an optimized ensemble algorithm for identification of from RNA-seq data. Analysis data several studies identified 87 differentially expressed genes. This was followed by ML protocol involving...
Salmonella infections pose a significant global public health concern due to the substantial expenses associated with monitoring, preventing, and treating infection. In this study, we explored core proteome of design multi-epitope vaccine through Subtractive Proteomics immunoinformatics approaches. A total 2395 proteins were curated from 30 different isolates (strain NZ CP014051 was taken as reference). Utilizing subtractive proteomics approach on proteome, Curlin major subunit (CsgA)...