A5071826155- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Pharmacological Receptor Mechanisms and Effects
- Helicobacter pylori-related gastroenterology studies
- Genomics and Rare Diseases
- Veterinary medicine and infectious diseases
- Microbial Natural Products and Biosynthesis
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- thermodynamics and calorimetric analyses
- RNA Interference and Gene Delivery
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Bioinformatics and Genomic Networks
- vaccines and immunoinformatics approaches
- Genetics, Bioinformatics, and Biomedical Research
Mawlana Bhashani Science and Technology University
2020-2025
Czech Academy of Sciences, Institute of Biotechnology
2021
National Institute of Biotechnology
2021
University of Kentucky
2021
Genetic polymorphisms in DNA damage repair and tumor suppressor genes have been associated with increasing the risk of several types cancer. Analyses putative functional single nucleotide (SNP) such can greatly improve human health by guiding choice therapeutics. In this study, we selected nine responsible for various cancer gene enrichment analysis found that BRCA1, ATM, TP53 were more enriched connectivity. Therefore, used different computational algorithms to classify nonsynonymous SNPs...
Abstract Background Helicobacter pylori is a gastric pathogen that responsible for causing chronic inflammation and increasing the risk of cancer development. It capable persisting decades in harsh environment because inability host to eradicate infection. Several treatment strategies have been developed against this bacterium using different antibiotics. But effectiveness treating H. has significantly decreased due widespread antibiotic resistance, including an increased cancer. The small...
Streptomyces coelicolor is a gram-positive soil bacterium which well known for the production of several antibiotics used in various biotechnological applications. But numerous proteins from its genome are considered hypothetical proteins. Therefore, present study aimed to reveal functions protein S. coelicolor. Several bioinformatics tools were employed predict structure and function this protein. Sequence similarity was searched through available databases find out homologous The secondary...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic emerged in 2019 and still requiring treatments with fast clinical translatability. Frequent occurrence of mutations spike glycoprotein SARS-CoV-2 led the consideration an alternative therapeutic target to combat ongoing pandemic. main protease (M pro ) is such attractive drug due its importance maturating several polyproteins during replication process. In present study, we used a classification structure–activity...
Developing a common medication strategy for disease control and management could be greatly beneficial. Investigating the differences between diseased healthy states using differentially expressed genes aids in understanding pathophysiology enables exploration of protein-drug interactions. This study aimed to find most diarrhea-causing bacteria such as Salmonella enterica serovar Typhimurium, Campylobacter jejuni, Escherichia coli, Shigella dysenteriae (CESS) new drugs. Thus, differential...
The emerging variants of SARS coronavirus-2 (SARS-CoV-2) have been continuously spreading all over the world and raised global health concerns. B.1.1.7 (United Kingdom), P.1 (Brazil), B.1.351 (South Africa) B.1.617 (India) variants, resulting from multiple mutations in spike glycoprotein (SGp), are resistant to neutralizing antibodies enable increased transmission. Hence, new drugs might be great importance against novel SARS-CoV-2. SGp main protease (M
Abstract Genetic polymorphisms in DNA damage repair and tumor suppressor genes have been associated with increasing the risk of several types cancer. Analyses putative functional single nucleotide (SNP) such can greatly improve human health by guiding choice therapeutics. In this study, we selected nine responsible for various cancer gene enrichment analysis found that BRCA1, ATM, TP53 were more enriched connectivity. Therefore, used different computational algorithms to classify...
Abstract The emerging variants of SARS Coronavirus-2 (SARS-CoV-2) has been continuously spreading all over the world and raised global health concerns. B.1.1.7 (United Kingdom), P.1 (Brazil), B.1.351 (South Africa) B.1.617 (India) resulted due to multiple mutations in spike glycoprotein (SGp), are resistant neutralizing antibodies enable increased transmission. Hence, new drugs might be great importance against novel SARS-CoV-2. SGp main protease (Mpro) SARS-CoV-2 important targets design...