A5045198947- vaccines and immunoinformatics approaches
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- Antibiotic Resistance in Bacteria
- Immunotherapy and Immune Responses
- COVID-19 and Mental Health
- Essential Oils and Antimicrobial Activity
- Bacteriophages and microbial interactions
- COVID-19 epidemiological studies
- Developmental Biology and Gene Regulation
- Public Health and Nutrition
- Spider Taxonomy and Behavior Studies
- SARS-CoV-2 detection and testing
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Neural Network Applications
- thermodynamics and calorimetric analyses
- Enterobacteriaceae and Cronobacter Research
- Enzyme function and inhibition
- Antimicrobial Peptides and Activities
- Advanced Optical Sensing Technologies
Baylor College of Medicine
2023
Jakarta State Polytechnic
2021-2022
University of Utah
2021-2022
Islamic University
2016-2021
East West University
2020
East–West University
2020
Ongoing COVID-19 outbreak has raised a drastic challenge to global public health security. Most of the patients with suffer from mild flu-like illnesses such as cold and fever; however, few percentages progress severe illness death, mostly in an immunocompromised individual. The causative agent is RNA virus known acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite these debilitating conditions, no medication stop disease progression or vaccination available till now. Therefore, we...
Elizabethkingia anophelis is an emerging human pathogen causing neonatal meningitis, catheter-associated infections and nosocomial outbreaks with high mortality rates. Besides, they are resistant to most antibiotics used in empirical therapy. In this study, therefore, we immunoinformatic approaches design a prophylactic peptide vaccine against E. as alternative preventive measure. Initially, cytotoxic T-lymphocyte (CTL), helper (HTL), linear B-lymphocyte (LBL) epitopes were predicted from...
Abstract Coronavirus disease 2019 (COVID-19), an infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic World Health Organization, and situation worsens daily, associated with increases in case fatality rates. The main protease (Mpro) enzyme produced SARS-CoV-2 was recently demonstrated to be responsible for not only viral reproduction but also impeding host immune responses. element selenium (Se) plays vital role functions,...
Fusarium wilt is an economically important disease of cucumber caused by the fungus oxysporum f. sp. cucumerinum (Foc). It causes severe losses in yield and quality extremely difficult to control conventionally using chemical fungicides. Biological offers eco-friendly alternative pesticide for sustainable plant management. In this context, biocontrol activity rhizosphere soil bacteria was investigated against Foc vitro. Thirty-five rhizobacterial isolates were screened antagonistic dual...
The novel coronavirus (2019-nCoV) has recently emerged, causing COVID-19 outbreaks and significant societal/global disruption. Importantly, infection resembles SARS-like complications. However, the lack of knowledge about underlying genetic mechanisms warrants development prospective control measures. In this study, we employed whole-genome alignment digital DNA-DNA hybridization analyses to assess genomic linkage between 2019-nCoV other coronaviruses. To understand pathogenetic behavior...
Abstract Background Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease transmitted to humans and livestock animals through the bite of infected ticks or close contact with persons’ blood, organs, other bodily fluids. The virus responsible for severe viral outbreaks, case fatality rate up 40%. Despite having highest virus, suitable treatment option vaccination has not been developed yet. Therefore, this study aimed formulate multiepitope vaccine against CCHF computational design...
Carbonic anhydrase IX (hCAIX) is a membrane-spanning metalloenzyme, encoded by CA9 gene, which can lead to various carcinomas if upregulated. Due its overexpression in many cancer tissues, hCAIX has become promising target for developing anticancer therapeutics. Furthermore, several classes of small-molecules have shown inhibit the expression. In this study, therefore, we screened (n = 42) plant-derived compounds identify most potent inhibitors and understand their interactions with drug...
Minichromosome maintenance protein 2 (MCM2) is a highly conserved from the MCM family that plays an important role in eukaryotic DNA replication as well cell cycle progression. In addition, it maintains ploidy level consistency cells, hence, mutations or alteration of this could result disintegration fine-tuned molecular machinery can lead to uncontrolled proliferation. Moreover, MCM2 has been found be marker for progression and prognosis different cancers. Therefore, we aimed analyze...
Despite the association of prevalent health conditions with coronavirus disease 2019 (COVID-19) severity, disease-modifying biomolecules and their pathogenetic mechanisms remain unclear. This study aimed to understand influences COVID-19 on different comorbidities vice versa through network-based gene expression analyses. Using shared dysregulated genes, we identified key genetic determinants signaling pathways that may involve in pathogenesis. The showed significant upregulation 93 genes...
Pseudomonas aeruginosa is an emerging opportunistic pathogen responsible for cystic fibrosis and nosocomial infections. In addition, empirical treatments are become inefficient due to their multiple-antibiotic resistance extensive colonizing ability. Quorum sensing (QS) plays a vital role in the regulation of virulence factors P. aeruginosa. Therefore, attenuation by QS inhibition could be alternative effective approach control this study, we sought discover new inhibitors (QSIs) against...
Background: With the insurgence of COVID-19 pandemic, many people died in past several months, and situation is ongoing with increasing health, social, economic panic vulnerability. As most countries relying on different preventive actions to control outcomes COVID-19, it necessary boost knowledge about effectiveness such so that policymakers take their country-based appropriate actions. This study generates evidence taking impactful combat COVID-19. Objective: In order generate...
<ns3:p><ns3:bold>Background:</ns3:bold> Rift Valley fever virus (RVFV) is an emerging arbovirus infecting both animals and humans. Any form of direct contact with body fluids, blood or tissue infected the mode transmission this pathogen. Despite being virus, no proper vaccinations are yet available for public. Our objective to compose a multiepitope vaccine utilizing immuno-bioinformatics as strategy against RVFV.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> To identify immunodominant...
Quorum sensing (QS) enables virulence factors in bacteria for biofilm formation and pathogenic invasion. Therefore, quorum quenching (QQ), disruption of QS circuit, becomes an alternative antimicrobial therapy. In this study, leaf extract Gynura procumbens (GP) was used to inhibit virulent Pseudomonas aeruginosa. The inhibited the production (p ≤ 0.05) P. aeruginosa strains MZ2F MZ4A. minimum eradication concentration (MBEC) recorded at 250 500 μg/ml while total activity found 288 144 ml/g,...
Background: Biofilm is a surface adhered extracellular polymer matrix produced by bacteria. The establishment of biofilms considered as an important pathogenic trait in many chronic infections and antibiotic resistance. Objective: present study was intended to evaluate biofilm forming potency resistance (AR) pattern clinical non-clinical bacterial isolates, their phylogenetic characterization. Materials Methods: A total 82 isolates were obtained from settings animal farms southern...