A5049662698- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- COVID-19 diagnosis using AI
- Diagnosis and treatment of tuberculosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Radiomics and Machine Learning in Medical Imaging
- HIV/AIDS Research and Interventions
- Infectious Diseases and Tuberculosis
- Cancer therapeutics and mechanisms
- Mobile Health and mHealth Applications
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- AI in cancer detection
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Digital Radiography and Breast Imaging
- Solar Thermal and Photovoltaic Systems
- Thermal Regulation in Medicine
- Digital Mental Health Interventions
- Artificial Intelligence in Healthcare and Education
- Vaccine Coverage and Hesitancy
International Centre for Diarrhoeal Disease Research
2016-2025
McGill University Health Centre
2023
Université Épiscopale d'Haiti
2023
Bangladesh University of Engineering and Technology
2023
BRAC University
2023
University of Chittagong
2016-2021
Hajee Mohammad Danesh Science and Technology University
2021
Universidade de Vigo
2020
National Institute of Cardiovascular Diseases
2018
Niigata Sangyo University
2004-2007
Artificial intelligence (AI) algorithms can be trained to recognise tuberculosis-related abnormalities on chest radiographs. Various AI are available commercially, yet there is little impartial evidence how their performance compares with each other and radiologists. We aimed evaluate five commercial for triaging tuberculosis using a large dataset that had not previously been used train any algorithms.Individuals aged 15 years or older presenting referred three screening centres in Dhaka,...
Abstract Coronavirus disease 2019 (COVID-19), an infectious caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a global pandemic World Health Organization, and situation worsens daily, associated with increases in case fatality rates. The main protease (Mpro) enzyme produced SARS-CoV-2 was recently demonstrated to be responsible for not only viral reproduction but also impeding host immune responses. element selenium (Se) plays vital role functions,...
Background GeneXpert MTB/RIF (Xpert) and Genotype MTBDRplus (DRplus) are two World Health Organization (WHO) endorsed probe based molecular drug susceptibility testing (DST) methods for rapid diagnosis of resistant tuberculosis. Both target the same 81 bp Rifampicin Resistance Determining Region (RRDR) bacterial RNA polymerase β subunit (rpoB) detection (RIF) resistance associated mutations using DNA probes. So there is a correspondence probes each other expected similarity binding. Methods...
Abstract This research describes an investigation of the antipyretic and hepatoprotective properties both a crude organic extract various subfractions ethnomedicinal plant Tinospora crispa , using appropriate animal models. In attempt to identify potential lead compounds, in silico experiments were utilized. Antipyretic activity was assessed via Brewer's yeast‐induced pyrexia method, while effects evaluated carbon tetrachloride (CCl 4 )‐induced model. A computer‐aided prediction spectra for...
Digital adherence technologies (DATs) have emerged as an alternative to directly observed therapy (DOT) for supervisions of tuberculosis (TB) treatment. We conducted a meta-analysis implementation feedback obtained from people with TB and health care workers (HCWs) involved in REACH Wave 6-funded DAT evaluation projects. Projects administered standardized post-implementation surveys based on the Capability, Opportunity, Motivation, Behavior (COM-B) model their workers. The included questions...
To evaluate the diagnostic performance of Xpert MTB/RIF Ultra (Ultra) for diagnosis extrapulmonary tuberculosis (EPTB) from different types specimens in comparison with culture and composite microbiological reference standard (CRS). A total 240 were prospectively collected presumptive EPTB patients between July 2021-January 2022 tested by Ultra, Xpert, acid-fast bacilli (AFB) smear microscopy. Out specimens, 35.8 %, 20.8 11.3 7.1 % detected as Mycobacterium complex AFB microscopy,...
Given the increases in drug-resistant tuberculosis, laboratory capacities for drug susceptibility testing are being scaled up worldwide. A must decide among several endorsed methodologies. We evaluated 87 Mycobacterium tuberculosis isolates concordance of results across six methods: L-J proportion method, MGIT 960 SIRE AST, Gene/Xpert MTB/RIF, GenoType MTBDRplus line probe assay, MycoTB MIC plate, and a laboratory-developed mycobacteriophage quantitative PCR (qPCR)-based method. Most (80%)...
Abstract Background The study was conducted to evaluate the analgesic, anti-inflammatory, antipyretic properties of ethanolic extract Tacca integrifolia rhizome (EETI) in mice and cytotoxic effects brine shrimp nauplii followed by a PASS prediction for some isolated compounds T. integrifolia. Additionally, this experiment included silico molecular docking ADME/T property analyses phytochemicals. Methods Formalin- induced paw licking test acetic acid-induced writhing analgesic activity,...
The World Health Organization recommends the Xpert MTB/RIF Ultra assay for diagnosing pulmonary tuberculosis (PTB) in children. Though stool is a potential alternative to respiratory specimens among children, diagnostic performance of on unknown. Thus, we assessed diagnose PTB children.We conducted cross-sectional study consecutively recruited children (< 15 years age) with presumptive admitted 4 tertiary care hospitals Dhaka, Bangladesh, between January 2018 and April 2019. Single induced...
With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has emerged as a promising threat to human health worldwide. Recently, the World Health Organization (WHO) announced infectious disease caused by SARS-CoV-2, which is known coronavirus disease-2019 (COVID-2019), global pandemic. Additionally, positive cases are still following upward trend worldwide and corollary, there need for potential vaccine impede progression of disease. Lately, it been...
The COVID-19 pandemic has impacted health systems and programs across the world. For tuberculosis (TB), it is predicted to set back progress by at least twelve years. Public private mix (PPM)has made a vital contribution reach End TB targets with ten-fold rise in notifications from providers between 2012 2019. This due large part efforts of intermediary agencies, which aggregate demand providers. put these gains risk over past year. In this rapid assessment, representatives 15 agencies seven...
Computer-aided detection (CAD) was recently recommended by the WHO for TB screening and triage based on several evaluations, but unlike traditional diagnostic tests, software versions are updated frequently require constant evaluation. Since then, newer of two evaluated products have already been released. We used a case control sample 12,890 chest X-rays to compare performance model programmatic effect upgrading CAD4TB qXR. compared area under receiver operating characteristic curve (AUC),...
Abstract Background Sputum smear microscopy is fast and inexpensive technique for detecting tuberculosis (TB) in high incidence areas but has low sensitivity. Physical chemical sputum processing along with centrifugation have been found to show promise overcoming this limitation. Our objective was compare the sensitivity of obtained smears made directly from respiratory specimens those concentrated specimens. Methods By active screening, 915 TB suspects were identified Dhaka Central Jail...
As the COVID-19 pandemic erupted, WHO recommended use of nasopharyngeal or throat swabs for detection SARS-CoV-2 etiology COVID-19. The collection NPS causes discomfort because its invasive procedure.
Background with Objective: Plantar fasciitis is a common condition causing heel and arch pain has been related degenerative changes in the plantar fascia resulting tissue thickening Musculoskeletal ultrasound imaging (MSK US) an emerging diagnostic tool which allows for dynamic visualization of tissues real time. There are very few available studies regarding musculoskeletal ultrasonography findings patient fasciitis. The aim this study was to observe ultrasonographic patients. Methods: This...
In developing settings, comparative data on COVID hospitalised survivors (HS) and non-hospitalised (NHS) is scarce. We determined burdens, incidence, evolution, associated factors of long COVID-19 over two years among these groups. conducted a longitudinal cohort study in Dhaka, Bangladesh, recruited confirmed from December 2020 to May 2021 (previously reported). 346 underwent in-person follow-ups at five, nine, 18 months post-infection. The assessment included symptoms, cardiorespiratory...
Adherence to tuberculosis preventive treatment (TPT) remains a significant challenge in high-burden countries like Bangladesh, where approximately 44 million people are infected with latent tuberculosis. This study protocol describes mixed-methods observational evaluate "iDOTS," locally developed digital adherence technology adapted from 99DOTS, for monitoring and improving TPT among adult household contacts of bacteriologically confirmed pulmonary TB patients. The will be conducted two...
Limited pharmacokinetic/pharmacodynamic (PK/PD) data exist on cycloserine in tuberculosis (TB) patients. We pooled several studies into a large PK set to estimate the population parameters for TB
The Xpert MTB/RIF (Xpert) assay technology allows rapid and sensitive diagnosis of pulmonary tuberculosis (PTB) from sputum specimens. However, PTB is difficult for patients who cannot produce sputum. objective this study was to investigate the use successful detection using stool samples adult subjects.Both known smear positive were collected a TB hospital in Dhaka. Stool healthy individuals without symptoms slum area decontaminated concentrated NALC-NaOH-Na-citrate solution resultant...
Rifampicin resistance (RR) is a key indicator of multidrug-resistant tuberculosis (MDR-TB) and 95% the RR associated with mutation in 81-bp rifampicin determining region (RRDR) rpoB gene Mycobacterium complex (MTBC). The Xpert MTB/RIF (Xpert) assay uses five overlapping molecular beacon probes (A-E) complementary to RRDR that detect MTBC mutations RR. objective study was investigate distribution frequency detected by among Beijing non-Beijing RR-TB isolates.A total 205 randomly selected...