A5100718358- Escherichia coli research studies
- Vibrio bacteria research studies
- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Global Maternal and Child Health
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 detection and testing
- Salmonella and Campylobacter epidemiology
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Trace Elements in Health
- Retinal and Optic Conditions
- Biosensors and Analytical Detection
- Healthcare Systems and Reforms
- Elbow and Forearm Trauma Treatment
- Thermoregulation and physiological responses
- Acute Myeloid Leukemia Research
- Influenza Virus Research Studies
- Blood disorders and treatments
- Facial Trauma and Fracture Management
- Dietary Effects on Health
- Atherosclerosis and Cardiovascular Diseases
- Robotics and Sensor-Based Localization
- Fibromyalgia and Chronic Fatigue Syndrome Research
Bangladesh University of Engineering and Technology
2019-2022
Rajshahi Medical College
2022
International Centre for Diarrhoeal Disease Research
2005-2020
Bangabandhu Sheikh Mujib Medical University
2016-2020
Bangladesh University of Business and Technology
2017
Institute of Development Studies
2016-2017
University of Sussex
2016
Dhaka Medical College and Hospital
2013
Massachusetts General Hospital
2010
Tufts University
2007-2009
ABSTRACT A cohort of 321 children was followed from birth up to 2 years age determine the incidence enterotoxigenic Escherichia coli (ETEC) in Bangladesh. The average number diarrheal days and rates were 6.6 2.3/child/year, respectively. ETEC most common pathogen isolated 19.5% cases, with an 0.5 episode/child/year. prevalence rotavirus diarrhea lower (10%). expressing heat-stable enterotoxin (ST) predominant. Strains cases positive for colonization factors (CFs) higher frequency (66%) than...
Wastewater based epidemiology (WBE) is an important tool to fight against COVID-19 as it provides insights into the health status of targeted population from a small single house large municipality in cost-effective, rapid, and non-invasive way. The implementation wastewater surveillance (WBS) could reduce burden on public system, management pandemics, help make informed decisions, protect health. In this study, with patients was for monitoring prevalence SARS-CoV-2 genetic markers samples...
In Bangladesh, the health risks of unplanned urbanization are disproportionately shouldered by urban poor. At same time, affordable formal primary care services scarce, and what exists is almost exclusively provided non-government organizations (NGOs) working on a project basis. So where do poor go for care? A facility mapping six slum settlements in Dhaka was undertaken to explore configuration healthcare proximate reside. Three methods were employed: (1) Social listing all Health Service...
ABSTRACT The mediators of protective immunity against cholera are currently unknown, but memory B-cell responses may play a central role in facilitating long-term and anamnestic Vibrio cholerae , the cause cholera. We compared adults with natural Bangladesh ( n = 70) to Bangladeshi after one-dose 30) or two-dose administration an oral killed vaccine, WC-rBS (Dukoral; Crucell), assessing at acute stage disease prevaccination then on days 3, 30, 90, 180, 270, 360. Individuals developed...
To investigate whether micronutrient supplementation could improve the vibriocidal antibody response of children to a killed oral cholera vaccine, 2–5-year-old were randomly assigned receive vitamin A and zinc (AZ group), placebo (A (Z or both placebos (P group). All received 2 doses vaccine. The number who had ⩾4-fold increase in was significantly greater AZ group than P (P=.025–.028). Factorial analysis suggested that proportion with titer zinc-supplemented groups did not (P=.013–.048)...
This case series study on central serous chorioretinopathy (CSCR) was conducted, from April 2022 to October 2022, assess the efficacy of laser photocoagulation and AntiVEGF in chorioretinopathy. included all patients presented with CSCR Bangladesh Eye Hospital, Uttara, Dhaka, a tertiary specialized private eye hospital Bangladesh. These cases were diagnosed clinically confirmed by fundus fluorescence angiogram optical coherence tomography. The main features evaluated corrected visual acuity,...
A live oral Vibrio cholerae O1 El Tor vaccine candidate, Peru-15, was studied for safety, immunogenicity, and excretion in phase 1 (inpatient) 2 (outpatient) studies of Bangladeshi adults.METHODs. The study conducted among adults, by use a double-blind, randomized, placebo-controlled design. single dose Peru-15 (approximately x 108 cfu) or placebo (buffer only) given standard bicarbonate ascorbic acid buffer.RESULTS. Study treatment did not elicit any major adverse events the volunteers,...
Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects CR humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned 30% or 10% group for 6 months. Delayed-type hypersensitivity (DTH), proliferation (TP), prostaglandin E(2) (PGE(2)) productions determined before after CR. DTH TP mitogens...
The Theory of Change (ToC) is a management and evaluation tool supporting critical thinking in the design, implementation development programmes. We document experience Future Health Systems (FHS) Consortium research teams Bangladesh, India Uganda with using ToC. seek to understand how why ToCs were applied clarify they facilitate iterative intervention designs stakeholder engagement health systems strengthening. This paper combines literature on ToC, summary reflections by FHS members...
Availability of Emergency Obstetric Care (EmOC) is crucial to avert maternal death due life-threatening complications potentially arising during delivery. Research on the determinants utilization EmOC has neglected urban settings, where traffic congestion can pose a significant barrier access facilities, particularly for poor costly and limited transportation options. This study investigates impact travel time facilities facility-based delivery services among mothers living in settlements...
Recent studies have shown that children with blood group A increased susceptibility to enterotoxigenic Escherichia coli (ETEC) diarrhea and Lewis "a" antigen (Le(a)) may be a candidate receptor for ETEC colonization factor (CF) I (CFA/I) fimbriae. Based on these findings, we attempted determine if the Le(a+b-) phenotype more susceptible caused by ETEC, in particular expressing CFA/I related fimbriae of group, than Le(a-b+) children. To test this hypothesis, determined expression 179...
Background Human genetic factors such as blood group antigens may affect the severity of infectious diseases. Presence specific ABO and Lewis has been shown previously to be associated with risk different enteric infections. The aim this study was determine relationship susceptibility cholera, well disease immune responses infection. Methodology We determined groups a cohort patients infected by Vibrio cholerae O1, their household contacts, healthy controls, analyzed symptomatic infection,...
Rifampicin resistance (RR) is a key indicator of multidrug-resistant tuberculosis (MDR-TB) and 95% the RR associated with mutation in 81-bp rifampicin determining region (RRDR) rpoB gene Mycobacterium complex (MTBC). The Xpert MTB/RIF (Xpert) assay uses five overlapping molecular beacon probes (A-E) complementary to RRDR that detect MTBC mutations RR. objective study was investigate distribution frequency detected by among Beijing non-Beijing RR-TB isolates.A total 205 randomly selected...
Colonization factor CS6 expressed by enterotoxigenic Escherichia coli (ETEC) is a nonfimbrial polymeric protein. A substantial proportion of ETEC strains isolated from patients in endemic settings and people who travel to regions where are expressing CS6, either alone or combination with fimbrial colonization CS5 CS4. However, relatively little known about the natural immune responses elicited against causing disease. We studied were hospitalized diarrhea (n = 46) caused CS6-expressing (ETEC...
We have studied homologous (HoM) and cross-reacting (CR) immunoglobulin A (IgA) antibody responses to colonization factors (CFs) in Bangladeshi children with diarrhea due enterotoxigenic E. coli (ETEC) strains of the CF antigen I (CFA/I) group (CFA/I, n = 25; surface 4 [CS4], 8; CS14, 11) CS5 (CS5, 15; CS7, 8), respectively. The HoM, CR, heterologous (HeT) antigens each patient were compared that seen healthy (n 20). In CFA/I (CFA/I CS14), patients responded antibody-secreting cell (ASC) HoM...
ABSTRACT Vibrio cholerae O1 and enterotoxigenic Escherichia coli (ETEC) are major bacterial pathogens that cause dehydrating disease requiring hospitalization of children adults. The cholera toxin (CT) produced by V. the heat-labile (LT) and/or heat-stable (ST) ETEC responsible for secretory diarrhea. We have observed about 13% hospitalized diarrheal patients concomitantly infected with ETEC. In order to understand outcome such dual infections on clinical immunological responses in patients,...