A5092123620- Computational Drug Discovery Methods
- vaccines and immunoinformatics approaches
- Phytochemistry and Biological Activities
- Infections and bacterial resistance
- Bioactive Compounds and Antitumor Agents
- Microbial infections and disease research
- SARS-CoV-2 and COVID-19 Research
- Cholinesterase and Neurodegenerative Diseases
- 14-3-3 protein interactions
- Phytochemicals and Antioxidant Activities
- Drug Transport and Resistance Mechanisms
- Botanical Research and Chemistry
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Natural Antidiabetic Agents Studies
- Phytochemical and Pharmacological Studies
- Bacterial biofilms and quorum sensing
- Genetic Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Cancer Genomics and Diagnostics
- Medicinal Plants and Neuroprotection
- Food Industry and Aquatic Biology
- Plant and Fungal Species Descriptions
- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
University of Science and Technology
2023-2024
International Islamic University Chittagong
2018
Isorhamnetin (C
Background: Breast cancer is a frequently diagnosed malignant disease and the primary cause of mortality among women with worldwide. The therapy options are influenced by molecular subtype due to intricate nature condition, which consists various subtypes. By focusing on activation receptors, Epidermal Growth Factor Receptor (EGFR) tyrosine kinase can be utilized as an effective drug target for therapeutic purposes breast cancer. Objectives: objective this study compare underlying...
The etiology of cervical cancer in women is attributed to the continuous infection human papillomavirus (HPV). high costs and side effects standard treatments limited efficacy HPV vaccination have led a quest for novel, cost-effective treatments, particularly middle- low-income countries. Therefore, our objective was evaluate capacity marine seaweed compounds hinder activity E6 Oncoprotein. Seaweed Metabolite Database evaluated its ability inhibit Oncoprotein functions by throughput virtual...
A glucose-dependent carbohydrate-signaling gene regulator named Carbohydrate response element binding protein (ChREBP), has recently been discovered as a major metabolic of enzymes involved in the progression non-alcoholic fatty liver disease (NAFLD) and type-II diabetes mellitus (T2DM). As result, this research is aimed to identify natural small molecules drug candidates that target ChREBP order counter aggressive NAFLD T2DM. comprehensive silico design strategy was implemented find...
Abstract Huntington's disease (HD) is a gradually severe neurodegenerative ailment characterised by an increase of specific trinucleotide repeat sequence (cytosine–adenine–guanine, CAG). It passed down as dominant characteristic that worsens over time, creating significant risk. Despite being monogenetic, the underlying mechanisms well biomarkers remain poorly understood. Furthermore, early detection HD challenging, and available diagnostic procedures have low precision accuracy. The...
Abstract Background The VCAN gene provides instructions for making a protein called versican which is type of known as proteoglycan. Versican key ingredient the extracellular matrix, and due to its widespread expression in body, involved cell adhesion, proliferation, migration. Mutations or alterations this could result disintegration fine-tuned molecular machinery can lead uncontrolled proliferation. Results novel prognostic marker multiple cancers, it showed tremendous results on breast...
Diabetes mellitus (DM) is a metabolic disorder arising from insulin deficiency and defectiveness of the receptor functioning on transcription factor where body loses control to regulate glucose metabolism in β-cells, pancreatic liver tissues homeostat level. Mainstream medicines used for DM are incapable restoring normal homeostasis have side effects medicinal plant-derived medicine administrations been claimed cure diabetes or at least alleviate significant symptoms progression disease by...
Abstract Hypertension, frequently coexists with Type 2 diabetes mellitus, causes due to Angiotensin II. Inhibiting II by targeting AT1R can potentially improve hypertension-related complications in patients T2DM. In this study, we perform an in-silico screening based on molecular docking and dynamic of 305 compounds Nigella sativa against Angiotensin-II Type1 Receptor (AT1R). Molecular studies were conducted investigate the binding affinities selected ligands target receptor compared...
Breast cancer progression is strongly influenced by estrogen receptor-α (ERα), a ligand-activated transcription factor that regulates hormone binding, DNA interaction, and transcriptional activation. ERα plays key role in promoting cell proliferation breast tissue, its overexpression associated with the advancement of through estrogen-mediated signaling pathways. Targeting is, therefore, promising therapeutic strategy for cancer. However, there are currently no phytochemical-based drug...
Background: The study was designed to investigate the phytochemical, analgesic, anti-arthritic, thrombolytic and cytotoxic evaluation of Begonia roxburghii (Miq.) DC leaves extract (nHBR) using both in vitro vivo methods.Methods: acetic acid induced writhing test formalin pain used perform anti-nociceptive activity on mice. In anti-arthritic assessed protein denaturation method. clot lysis considered evaluate potentials plant extract. performed brine shrimp larvae.Results: phytochemical has...
Pneumonia, an infectious lung disease, is a significant global health concern, claiming the lives of 740,180 children in 2019, which accounts for 14% pediatric deaths. Recently, management pneumonia has become complex due to exposure indoor and outdoor environmental toxins. Notably, pollutants antibiotic-resistant bacteria during community hospital-acquired poses serious threat patient outcomes. The development antibiotic resistance against Streptococcus pneumoniae driven by DinF efflux pump...
<title>Abstract</title> Antibiotic resistance in bacteria leads to high mortality rates and healthcare costs, a significant concern for public health. A colonizer of the human respiratory system, <italic>Stenotrophomonas maltophilia</italic> is frequently associated with hospital-acquired infections individuals cystic fibrosis, cancer, other chronic illnesses. It multidrug-resistant pathogen without an approved vaccine. multi-epitope vaccine against <italic>S. has been developed using...
Abstract Herbal remedies have shown great promise for improving human health. The plant Crotalaria quinquefolia is used in folk medicine to cure different diseases, including scabies, fever, discomfort, and lung infections. present research was designed explore bioactive compounds evaluate the neuropharmacological effects of C. extract through vivo silico approaches. Different secondary metabolites as well antioxidant activity were measured. Furthermore, chemical identified by HPLC GCMS...
Avian Influenza (AI), or bird flu predominantly caused infection and disease to the birds. The highly pathogenic avian influenza (HPAI) causes enormous socioeconomic losses in poultry industry worldwide. surface glycoproteins hemagglutinin (HA) (NA) viruses. Highly H5N1 subtype of spreading throughout world serious threat human as well. Due continuous emergence novel strains ineffective antiviral drugs, suitable effective therapeutics against this virus must be developed. Computational...