A5066253874- Computational Drug Discovery Methods
- Aquaculture disease management and microbiota
- vaccines and immunoinformatics approaches
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Mosquito-borne diseases and control
- Carbon Nanotubes in Composites
- Bioinformatics and Genomic Networks
- Identification and Quantification in Food
- Coral and Marine Ecosystems Studies
- Boron and Carbon Nanomaterials Research
- Melanoma and MAPK Pathways
- Marine Sponges and Natural Products
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Aquatic life and conservation
- Viral Infections and Vectors
- Synthesis and bioactivity of alkaloids
- Viral Infections and Outbreaks Research
- Birth, Development, and Health
- Click Chemistry and Applications
- Phase Equilibria and Thermodynamics
- Bioactive Compounds and Antitumor Agents
- Quinazolinone synthesis and applications
University of Vermont
2024-2025
King Abdulaziz University
2020-2024
University of Chittagong
2020-2022
Khulna University
2022
Khulna Agricultural University
2022
Pukyong National University
2019
Payame Noor University
2018
Islamic Azad University, Science and Research Branch
2016
Walleye dermal sarcoma virus (WDSV) is a type of retrovirus, which affects most the adult walleye fishes during spawning time. The causes multiple epithelial tumors on fish’s skin and fins that are liable for more than 50% mortality rate fish around world. Till now, no effective antiviral drug or vaccine candidates have been developed can block progression disease caused by pathogen. It was found 582-amino-acid (aa) residues long internal structural gag polyprotein plays an important role in...
Pancreatic cancer is a very deadly disease with 5-year survival rate, making it one of the leading causes cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) ubiquitously expressed protein in pancreatic cancer. FAK, tyrosine that overexpressed cells, crucial for development tumors into malignant phenotypes. FAK functions response to extracellular signals by triggering transmembrane receptor signaling, which enhances focal turnover, cell adhesion, migration, and gene expression....
Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting approximately 1.9 million individuals in 2020. Therapeutics disease are not yet available and discovering a novel anticancer drug candidate against an urgent need. Thymidylate synthase (TS) important enzyme prime precursor for DNA biosynthesis that catalyzes methylation deoxyuridine monophosphate (dUMP) to deoxythymidine (dTMP) has emerged as target disease. Elevated expression TS proliferating cells...
Minichromosome maintenance protein 2 (MCM2) is a highly conserved from the MCM family that plays an important role in eukaryotic DNA replication as well cell cycle progression. In addition, it maintains ploidy level consistency cells, hence, mutations or alteration of this could result disintegration fine-tuned molecular machinery can lead to uncontrolled proliferation. Moreover, MCM2 has been found be marker for progression and prognosis different cancers. Therefore, we aimed analyze...
White spot syndrome virus (WSSV) is an enveloped pathogenic of cultured shrimp that has a mortality rate up to 100 % in intensive aquaculture systems. The virulent pathogen causes economic loss estimated at US$1 billion annually global and prawn production. To date, no effective antiviral or vaccine been progress can reduce the losses caused by pathogen. complex genomic structure nucleocapsid virus, consisting double-stranded DNA as genetic material surrounded lipid envelope protein. It...
Breast cancer (BC) is the most common malignancy worldwide, including in Saudi Arabia. Because of its heterogeneous nature, existing diagnostic and prognostic biomarkers are not relevant for all cases. There a need to discover novel early diagnosis prognosis reduce mortality. Herein, we utilized an integrative bioinformatics approach identify potential BC. Gene expression profiling 45 BC five normal samples from KAUH, Jeddah was done with GeneChip Human Genome 1.0 ST Array. Data analyzed by...
Fish represent an excellent source of animal protein as well a biomedical research model result their evolutionary relatedness and similarity with the human genome. Commercial ornamental fish culture has achieved popularity, but reproductive dysfunctions act limiting factor for quality fry production, interfering sustainability aquaculture industry. reproduction is crucial any species’ existence, performance can potentially be improved through applications epigenetics probiotics. Epigenetics...
Sea urchin-derived compounds are potential candidates for the development of effective drugs treatment cancer diseases. In this study, 19 derived from sea urchin (Diadema savignyi) were used to treat colorectal using HCT116 cell line. However, molecular docking, ADME (absorption, distribution, metabolism, and excretion), toxicity, dynamic (MD) simulation, mechanics generalized Born surface area (MM-GBSA) confirm ligand-protein interaction. Interactions Importin-11 receptor with reveal that...
The BRAF gene is responsible for transferring signals from outside of the cell to inside nucleus by converting a protein namely B-Raf through RAS/MAPK pathway. This pathway contribute division, proliferation, migration, and apoptotic death human animal. Mutation in this may cause development several cancers, including lung, skin, colon, neuroblastoma. Currently, few available drugs are being used that has developed targeting mutated protein, due toxic side effects, patients suffer lot during...
Abstract Background Flavin monoamine oxidase gene encodes a protein (MAOB) that forms part of the flavin family in outer membrane mitochondria. It plays role tissue metabolism neuroactive and vasoactive amines as well oxidative deamination xenobiotic biogenic amines. However, overexpression receptor reduced apoptosis cells, resulting progress prostate sarcoma. Therefore, various kinds MAOB antagonists are often used to fix an mechanism makes it hard get rid cancer from live tissues....
Tilapia Lake Virus (TiLV) is a disease that affects tilapia fish, causing high rate of sudden death at any stage in their life cycle. Unfortunately, there are currently no effective antiviral drugs or vaccines to prevent control the progression this disease. Researchers have discovered CRM1 protein plays critical function development and spreading animal viruses. By inhibiting CRM1, virus's spread commercial fish farms can be suppressed. With mind, study intended identify potential from two...
The common carp Cyprinus carpio is a freshwater teleost and among the most economically significant fishes in aquaculture throughout world. Taxonomically, C. are complex of species including subspecies carpio. now threatened by Cyprinid Herpesvirus-3 (CyHV-3), causative agent Koi Herpesvirus Disease (KHVD), which causes severe morbidity mortality ornamental koi can infect or be transmitted other species. Despite these devastating circumstances, effective vaccinations medications for control...
Maternally derived thyroid hormones (THs) deposited in yolk promote fish embryogenesis and survival, understanding early regulatory mechanisms could lead to improved seedstock production. We have tested the hypothesis that some actions may be mediated by insulin-like growth factor I (IGF-1), another promoter of embryo development. Differentiation performance were assessed embryos treated with THs presence or absence an IGF-1 receptor blocking peptide. Treatment TH triiodothyronine (T3)...
Sea Urchin is not only the crucial keystone species for coral reef restoration but also it has antimicrobial and anti-cancer activities. This study undertaken to focus on length weight relationship, size fecundity distribution estimation of from long-spined Urchin, Diadema savignyi at coastal water middle Red Sea, Saudi Arabia. A total 633 specimen D. been collected Obhur Creak during sampling time. In each species, (TL) measured as a TW = 11.908 × 0.9995 (R2 0.8975) through linear...
Environmental enrichment (EE) is an important factor that helps improve both the physical and psychological behavior of farmed animals. This also controls social interactions provides more stimulants to influence reproductive performance animals in captivity. As EE plays role animal reproduction, present study was designed investigate effects different types tank bottom enrichments on ovarian development Buitta (Sperata sp.) catfish Barren (TA), muddy (TB), sandy (TC) were utilized for four...
Tilapia (Oreochromis spp.) have significant potential for aquaculture production around the world. There is an increasing demand among tilapia producers strains with higher yields and fish that can survive in highly saline water. Novel consistent seedstock are critically important objectives sustainable aquaculture, but these required targets there still not enough progress. Therefore, this study describes genome sequence of Oreochromis spilurus to support seawater culture tilapia. The draft...
The Indo-Pacific region sometimes referred to as the Indo-West Pacific, is considered be richest marine biodiversity hotspot comprising unique species of echinoderms, molluscs, shrimps, crabs and fishes. These bioresources provide excellent opportunities for studies breeding biology, reproductive ecology, aquaculture, conservation, population genetics well speciation mechanisms many diverged taxa. However, this interesting area quite new yet fully explored determined. In bottom-dwelling...
Abstract Tilapia Lake Virus (TiLV) is a disease that affects tilapia fish, causing high rate of sudden death at any stage their growth. Unfortunately, there are currently no effective antiviral drugs or vaccines to control the progression this disease. Researchers have discovered CRM1 protein plays critical function in development and spreading animal viruses. By inhibiting CRM1, virus’s spread commercial fish farms can be suppressed. With mind, study intended identify potential from two...