A5066339428- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Cholinesterase and Neurodegenerative Diseases
- Crystallization and Solubility Studies
- Advancements in Transdermal Drug Delivery
- Analytical Methods in Pharmaceuticals
- Electrochemical sensors and biosensors
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Nanomaterials for catalytic reactions
- Advanced Nanomaterials in Catalysis
- COVID-19 epidemiological studies
- Click Chemistry and Applications
- Mathematical and Theoretical Epidemiology and Ecology Models
- Nanoparticles: synthesis and applications
- Nanocluster Synthesis and Applications
- Wound Healing and Treatments
- Nanoparticle-Based Drug Delivery
- Alzheimer's disease research and treatments
- Drug-Induced Hepatotoxicity and Protection
- Synthesis and Biological Evaluation
- Medicinal Plants and Neuroprotection
- Fractional Differential Equations Solutions
- Hydrogels: synthesis, properties, applications
- Pneumothorax, Barotrauma, Emphysema
Taif University
2013-2024
Ain Shams University
2023
Beni-Suef University
2013-2021
American Pharmacists Association
2018
King Abdulaziz University
2013
Fungal keratitis (FK) is a serious pathogenic condition usually associated with significant ocular morbidity. Natamycin (NAT) the first-line and only medication approved by Food Drug Administration for treatment of FK. However, NAT suffers from poor corneal penetration, which limits its efficacy treating deep keratitis.The objective this work was to prepare solid lipid nanoparticles (NAT-SLNs) achieve sustained drug release increased penetration.NAT-SLNs were prepared using...
BCS class II drugs usually suffer inadequate bioavailability as dissolution step is the absorption rate limiting step. In this work, effect of solubility increase at main site for these was investigated using risperidone a drug model. Liquisolid technique applied to prepare per-oral tablets high intestinal pH (6.8) versatile nonionic surfactants solubilizing ability [Transcutol HP, Labrasol and Labrasol/Labrafil (1:1) mixture] liquid vehicles different concentrations (10–30%) fixed (R). The...
The aim of this research is to formulate a lecithin–chitosan based nanoparticulate system loaded with berberine (BER-LC-CTS-NPs) that could be integrated into topically applied formulation and assessed for healing wounds in diabetic animal model. In order BER-LC-CTS-NPs, soybean lecithin, isopropyl myristate, dispersed ethanolic solution were added an aqueous chitosan dropwise sonication. We the influence lecithin amount, myristate concentration on particle diameter, zeta potential,...
Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM used to treat inflammation, skeletal muscle injuries, and discomfort associated with bone disorders. Because of the delayed absorption from gastro intestinal tract (GIT), currently available dosage forms have rather protracted start effect, according pharmacokinetic studies. The aim this study was create combination for fast dissolving tablets (TLM-FDT) that would boost drug's bioavailability by increasing...
The purpose of the study was to develop an SNEDDS improve solubility and bioavailability pitavastatin. pitavastatin in different oils, surfactants, co-surfactants determined a pseudo-ternary phase diagram constructed. characterized by zeta-sizer, zeta-potential, FTIR, DSC, TGA. Release permeation from studied for 12 24 h, respectively. lipolysis test, RBC lysis, effect on lipid profile, pharmacokinetics were studied. SPC3 formulation showed 104 ± 1.50 nm particle size, 0.198 polydispersity...
Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting approximately 1.9 million individuals in 2020. Therapeutics disease are not yet available and discovering a novel anticancer drug candidate against an urgent need. Thymidylate synthase (TS) important enzyme prime precursor for DNA biosynthesis that catalyzes methylation deoxyuridine monophosphate (dUMP) to deoxythymidine (dTMP) has emerged as target disease. Elevated expression TS proliferating cells...
Because Eplerenone (EPL) is a Biopharmaceutical Classification System (BCS) class-II drug and prone to extensive liver degradation, it suffers from poor bioavailability after oral administration. This work aimed prepare liquisolids loaded with EPL-nanoemulsions (EPL-NEs) that have higher release rate improved by the route. Based on solubility studies, mixtures of Triacetin (oil) Kolliphor EL/PEG 400 surfactant/co-surfactant (Smix) in different ratios were used EPL-NE systems, which...
A series of halogenated coumarin-chalcones were synthesized, characterized, and their inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) evaluated. Compound CC2 most potently inhibited MAO-B with an IC50 value 0.51 μM, followed by CC1 (IC50 = 0.69 μM), a selectivity index (SI) >78.4 >58.0, respectively, over MAO-A. However, none the compounds effectively MAO-A, AChE,...
Nicergoline (NIC) is a semisynthetic ergot alkaloid derivative applied for treatment of dementia and other cerebrovascular disorders. The efficacy sesame oil to slow reverse the symptoms neurodegenerative cognitive disorders has been proven. This work aimed formulate optimize oil-based NIC-nanostructured lipid carriers (NIC–NLCs) intranasal (IN) delivery with expected synergistic augmented neuroprotective properties. NIC–NLC were prepared using as liquid lipid. A three-level, three-factor...
Glimepiride (GMP), an oral hypoglycemic agent is extensively employed in the treatment of type 2 diabetes. Transdermal delivery GMP has been widely investigated as a promising alternative to approach but hindered owing its low solubility and permeation. The present study was designed formulate topical nanoemulgel system previously reported enhanced glimepiride (GMP/βCD/GEL-44/16) combination with anti-diabetic oil enhance effect. Nanoemulsions were developed using clove oil, Tween-80,...
Six halogenated trimethoxy chalcone derivatives (CH1–CH6) were synthesized and spectrally characterized. The compounds further evaluated for their inhibitory potential against monoamine oxidases (MAOs) β-secretase (BACE-1). inhibited MAO-B more effectively than MAO-A, the 2′,3′,4′-methoxy moiety in CH4–CH6 was effective inhibition 2′,4′,6′-methoxy CH1–CH3. Compound CH5 most potently MAO-B, with an IC50 value of 0.46 µM, followed by CH4 (IC50 = 0.84 µM). In (CH4-CH6), order –Br > -Cl -F...
The majority of newly developed drugs need to be incorporated with delivery systems maximize their effect and minimize side effects. Nanoemulsions (NEs) are one type system that helps improve the solubility dissolution drugs, attempting enhance bioavailability onset action. objective this investigation was develop an omega-3 oil-based NE loaded loxoprofen (LXP) its dissolution, in vitro release, mucosal penetration decrease ulcerative effects when applied oral treatment. LXP-loaded NEs were...
The occurrence of fungal infections has increased over the past two decades. It is observed that superficial are treated by conventional dosage forms, which incapable treating deep due to barrier activity possessed stratum corneum skin. This why need for a topical preparation with advanced penetration techniques arisen. research aimed encapsulate fluconazole (FLZ) in novasome order improve delivery. novasomes were prepared using ethanol injection technique and characterized percent...
Infectious diseases are the major source of increasing death rate during recent years. Among infectious diseases, dengue fever is disseminated in more than hundred countries, especially tropical and subtropical regions. In this work, a novel fractional model presented which describes dynamics including human vector (mosquitoes) population. The mathematical transmission important to understand dynamical behavior disease. A compartmental composed five compartments representing mosquito...
The objective of this study was to improve the dissolution and solubility dexibuprofen (DEX) using hydroxypropyl beta cyclodextrin (HPβCD) inclusion complexes also evaluate effect presence hydrophilic polymers on solubilization efficiency HPβCD. Three different methods (physical trituration, kneading solvent evaporation) were used prepare binary at various drug-to-cyclodextrin weight ratios. An increase in drug release observed with (KN) method a DEX/HPβCD (1:4) ratio. addition poloxamer-188...
Poor solubility is the major challenge involved in formulation development of new chemical entities (NCEs), as more than 40% NCEs are practically insoluble water. Solid dispersion (SD) a promising technology for improving dissolution and, thereby, bioavailability poorly soluble drugs. This study investigates influence pH-sensitive acrylate polymer, EPO, on physicochemical properties rosuvastatin calcium, an antihyperlipidemic drug. In silico docking was conducted with numerous polymers to...
Objective: The objective of this study was to investigate the photoprotective effect liquisolid technique on amlodipine, a calcium channel blocker antihypertensive drug, representing photosensitive drug model. Method: Several formulations were prepared using propylene glycol as water-miscible nonvolatile vehicle at drug/solvent ratio (1:1), Avicel PH 102 carrier, nanometer-sized amorphous silicon and titanium dioxide either alone or in combination coating materials. carrier/coat (R) varied...
The main objective of this research work was the development and evaluation transfersomes integrated oral films for bioavailability enhancement Ebastine (EBT) to treat allergic rhinitis. flexible transfersomes, consisting drug (EBT), lipid (Phosphatidylcholine) edge activator (EA) Polyoxyethylene sorbitan monooleate or Sorbitan monolaurate, were prepared with conventional thin film hydration method. developed further into using solvent casting Transfersomes evaluated their size distribution,...
Fifteen multiconjugated dienones (MK1-MK15) were synthesized and evaluated to determine their inhibitory activities against monoamine oxidases (MAOs) A B. All derivatives found be potent highly selective MAO-B inhibitors. Compound MK6, with an IC50 value of 2.82 nM, most effectively inhibited MAO-B, like MK12 (IC50 = 3.22 nM), followed by MK5, MK13, MK14 4.02, 4.24, 4.89 respectively). The selectivity index values MK6 for over MAO-A 7361.5 1780.5, respectively. Compounds competitive...
Merkel cell carcinoma (MCC) is a rare form of aggressive skin cancer mainly caused by polyomavirus (MCPyV). Most MCC tumors express MCPyV large T (LT) antigens and play an important role in the growth-promoting activities oncoproteins. Truncated LT promotes tumorigenicity as well host proliferation activating viral replication machinery, inhibition this protein humans drastically lowers cellular growth linked to corresponding cancer. Our study was designed with aim identifying small...
The monoamine oxidase (MAO) enzyme class is a prevalent target for many neurodegenerative and depressive disorders. Even though scrutinization of promising drugs the treatment MAO inhibition has been carried out in recent times, conclusive structural requirement potent activity needs to be developed. Numerous approaches have examined identification features inhibitors (MAOIs) that mainly involve an array computational studies, synthetic approaches, biological evaluation. In this paper, we...
The current investigations of the COVID-19 spreading model are presented through artificial neuron networks (ANNs) with training Levenberg-Marquardt backpropagation (LMB), i.e., ANNs-LMB. ANNs-LMB scheme is used in different variations sample data for training, validation, and testing 80%, 10%, respectively. approximate numerical solutions have been calculated using compared viably reference dataset based on Runge-Kutta scheme. obtained performance solution dynamics to minimize values...