A5030598899- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Cancer-related gene regulation
- Radiation Dose and Imaging
- Histone Deacetylase Inhibitors Research
National Institute of Nuclear Medicine & Allied Sciences
2024
King Abdulaziz University
2022
Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting approximately 1.9 million individuals in 2020. Therapeutics disease are not yet available and discovering a novel anticancer drug candidate against an urgent need. Thymidylate synthase (TS) important enzyme prime precursor for DNA biosynthesis that catalyzes methylation deoxyuridine monophosphate (dUMP) to deoxythymidine (dTMP) has emerged as target disease. Elevated expression TS proliferating cells...
Ubiquitin-like containing plant homeodomain Ring Finger 1 (UHRF1) protein is recognized as a cell-cycle-regulated multidomain protein. UHRF1 importantly manifests the maintenance of DNA methylation mediated by interaction between its SRA (SET and RING associated) domain methyltransferase-1 (DNMT1)-like epigenetic modulators. However, overexpression epigenetically responds to aberrant global promotes tumorigenesis. To date, no potential molecular inhibitor has been studied against domain....
Purpose: The primary objectives of this study were threefold: first, to comprehensively assess radiation exposure levels within the Nuclear Medicine (NM) institution; second, identify and address potential risks associated with diagnostic therapeutic procedures; third, establish strong control measures emergency response plans. These goals collectively aim contribute creation a personalized protection program that addresses unique issues provided by NM applications. Materials Methods:...
Objective: To determine the correlation of international prostate symptom score with volume and Intravesical protrusion prostate. Methods: This cross-sectional study was performed on 60 elderly patients presented LUTS suggestive Benign Enlargement Prostate. Their evaluation included DRE, IPSS, Uroflowmetry (Qmax), serum PSA measurements transabdominal ultrasound scan. Statistical analysis by SPSS version 13 using Chi square test scatter plots together Spearmna’s coefficients were used to...