A5004746102- Drug-Induced Hepatotoxicity and Protection
- Biochemical and biochemical processes
- Ubiquitin and proteasome pathways
- Pharmacological Effects of Natural Compounds
- Histone Deacetylase Inhibitors Research
- Liver Disease and Transplantation
- Medicinal Plants and Neuroprotection
- Bioactive Compounds and Antitumor Agents
- Hydrogen's biological and therapeutic effects
- Nigella sativa pharmacological applications
- Genomics, phytochemicals, and oxidative stress
- Urinary Bladder and Prostate Research
- Tannin, Tannase and Anticancer Activities
- PARP inhibition in cancer therapy
- Liver Disease Diagnosis and Treatment
- Luminescence and Fluorescent Materials
- Mathematical Biology Tumor Growth
- Ocular Surface and Contact Lens
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Reproductive biology and impacts on aquatic species
- Psoriasis: Treatment and Pathogenesis
- Erythropoietin and Anemia Treatment
- Signaling Pathways in Disease
- Carcinogens and Genotoxicity Assessment
King Abdulaziz University
2013-2025
King Saud University
2025
Armed Forces Hospital
2024
Inserm
2021-2024
Université de Strasbourg
2021-2024
Centre National de la Recherche Scientifique
2021-2024
Institut de génétique et de biologie moléculaire et cellulaire
2021-2024
Breast cancer (BC) is one of the most common cancers in women and a major cause female cancer-related deaths. BC multifactorial disease caused by dysregulation many genes, raising need to find novel drugs that function targeting several signaling pathways. The antitumoral drug thymoquinone (TQ), found black seed oil, has multitargeting properties against This study evaluated inhibitory effects TQ on MCF7 T47D human breast cell lines its antitumor activity induced single oral dose (65 mg/kg)...
Europinidin is a novel anthocyanidin found in the petals of Plumbago europea that exhibits several physiological effects. Research was conducted to assess europinidin's cardioprotective efficacy diabetic and myocardial infarction (MI) experimental model. Rat injected through intraperitoneal administration 45 mg/kg streptozotocin (STZ), while MI induced by subcutaneously administering 85 isoproterenol (ISP) at 24 48 h prior sacrifice procedure. 10 20 mg/day administered orally for 4 weeks...
Background: Clinical Hereditary Hemolytic Anemia (HAA) particularly Spherocytosis (HS) encompasses diverse genetic disorders causing premature red blood cell destruction and intrinsic RBC defects. There’s a pressing need for standardized diagnostic protocols tailored to the Asian population, in Saudi Arabia, underscoring significance of thorough biochemistry analysis. Materials Methods: A case-control prospective study was conducted at King Abdulaziz University, samples were obtained from...
Background: Infertility was often considered a female issue, but male infertility emerged significantly after the Covid-19 pandemic. Hence, assessments are crucial for planning policies on health care and family reasons thereof post vaccinations. Material Methods: The present study case-control, dual-centers, prospective with normal sperm parameters. Semen samples collected by masturbation idiopathic were conducted at King Abdulaziz University 133 samples, followed molecular modeling via...
Methamphetamine (MA) is well recognized as a psychostimulant that can cause neurotoxicity and neurodegeneration, which associated with cognitive decline, has been confirmed experimentally.
We designed a highly sensitive fluorescent sensor for the early detection of sarcosine, potential biomarker prostate cancer. This was based on surface-cobalt-doped carbon quantum dots (Co-CD) using FRET-based photoluminescent sensing platform. Blue luminescent (CQD) were synthesised through hydrothermal approach, utilizing Delonix regia tree pod shells. Cobalt employed to functionalize CQD, enhancing quantum-entrapped effects and minimizing surface flaws. To optimize Co-CD preparation, we...
Background: Cardiovascular diseases (CVDs) continue to exert a substantial global influence in specific areas due population growth, aging, microbiota, and genetic/environmental factors. Drinking water has strong impact on the health of an individual. Further, emerging evidence highlighted therapeutic potential benefits Zamzam (Zam). Objective: We investigated Zam doxorubicin-induced cardiac toxicity, elucidating its consequential effects GUT microbiota dysbiosis hepatic renal functions....
Malvidin is a natural, biologically active polyphenol found in several fruits. It exhibits therapeutic benefits; however, limited studies are available on its effects neurodegenerative clinical conditions, including Parkinson's disease. The study aimed to investigate the properties of malvidin rotenone-triggered disease an animal model.
Huntington's disease (HD) is an extremely harmful autosomal inherited neurodegenerative disease. Motor dysfunction, mental disorder, and cognitive deficits are the characteristic features of this The current study examined whether 6-shogaol has a protective effect against 3-Nitropropionic Acid (3-NPA)-induced HD in rats.
6-Shogaol is a comparatively innovative anti-Parkinson's remedy with antioxidant and anti-inflammatory characteristics. This investigation intended to determine the role of 6-shogaol in Parkinson's disease (PD) paradigm rotenone-induced rats.
Type 2 diabetes mellitus (T2DM) is defined by a wide variety of metabolic abnormalities, persistent hyperglycemia, and slew other complications.
The current study explored the protective potential of kaempferol 3-sophoroside-7-glucoside (KSG) against acute lung injury (ALI). Pre-treatment with KSG effectively secured mice from ALI and showed similar efficaciousness to dexamethasone. markedly increased survival rate alleviated pathological lesions induced by lipopolysaccharide (LPS). Furthermore, attenuated differential total cell counts in BALF (bronchoalveolar lavage fluid) MPO (myeloperoxidase) activity. counteracted NF-κB (nuclear...
Fustin, a photogenic flavanol found in the plant Rhus verniciflua Stokes, has been involved multiple disease ailments and beneficial pharmacological effect history of use traditional medicine. The present research aimed to study impact fustin on scopolamine (SCOP)-induced memory impairment neurodegeneration by modulating neuroinflammation neurotransmitters rats.
Maritime pine bark is a rich source of polyphenolic compounds and commonly employed as herbal supplement worldwide.
Environmental enrichment (EE) is an important factor that helps improve both the physical and psychological behavior of farmed animals. This also controls social interactions provides more stimulants to influence reproductive performance animals in captivity. As EE plays role animal reproduction, present study was designed investigate effects different types tank bottom enrichments on ovarian development Buitta (Sperata sp.) catfish Barren (TA), muddy (TB), sandy (TC) were utilized for four...
Background: Gliomas are the most frequent, heterogeneous group of tumors arising from glial cells, characterized by difficult monitoring, poor prognosis, and fatality. Tissue biopsy is an established procedure for tumor cell sampling that aids diagnosis, grading, prediction prognosis. Materials Methods: We studied compared levels liquid markers in patients with different grades glioma. Also, we tried to prove potential association between glioma specific blood antigens. Results: 78 were...
Background: Clinical endocrinology has observed emerging endocrine complications following COVID-19 vaccination, amidst successful reductions in hospitalizations and deaths. The Pfizer-BioNTech Moderna mRNA vaccines have demonstrated efficacy. Reports indicate a potential association between SARS-CoV-2 vaccination diabetes, exploring interactions with ACE-2 receptors molecular mimicry. Additionally, altered liver kidney function tests post-vaccination prompt investigation into their role...